Annotations: 2FOO

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MATH	e2fooA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: TRAF domain-like (From Topology)	T: TRAF domain-like	F: MATH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.210.10	Mainly Beta	Sandwich	Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF22486	MATH domain (MATH_2)	MATH domain	This motif has been called the Meprin And TRAF-Homology (MATH) domain.ED A0A835B747.1/23-123; A0A835B747.1/23-76;	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ubiquitin carboxyl-terminal hydrolase 7	p53 binding protein binding binding ubiquitin-like protein peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity K48-linked deubiquitinase activity catalytic activity deubiquitinase activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity cysteine-type deubiquitinase activity	regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process biological regulation primary metabolic process regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression regulation of molecular function biosynthetic process regulation of DNA-binding transcription factor activity cellular process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process regulation of protein stability regulation of biological quality protein stabilization negative regulation of biological process negative regulation of gene expression via chromosomal CpG island methylation cellular component organization chromatin organization negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process epigenetic regulation of gene expression negative regulation of metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic rhythmic process circadian rhythm regulation of circadian rhythm regulation of localization cellular localization regulation of transport transport intracellular transport regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport endosomal transport localization regulation of cellular localization cytosolic transport establishment of localization in cell retrograde transport, endosome to Golgi regulation of retrograde transport, endosome to Golgi regulation of intracellular transport protein ubiquitination macromolecule modification protein metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein deubiquitination monoubiquitinated protein deubiquitination protein modification by small protein removal cellular response to stimulus response to stimulus DNA metabolic process DNA alkylation repair cellular response to stress DNA damage response response to stress DNA repair transcription-coupled nucleotide-excision repair nucleotide-excision repair negative regulation of DNA-binding transcription factor activity negative regulation of NF-kappaB transcription factor activity negative regulation of molecular function catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process negative regulation of protein catabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis negative regulation of protein metabolic process negative regulation of ubiquitin-dependent protein catabolic process negative regulation of catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein metabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process negative regulation of proteasomal protein catabolic process regulation of proteasomal protein catabolic process ubiquitin-dependent protein catabolic process regulation of protein catabolic process establishment of protein localization to telomere protein localization establishment of protein localization regulation of protein localization regulation of protein localization to chromosome, telomeric region cellular macromolecule localization establishment of protein localization to chromosome regulation of establishment of protein localization to chromosome regulation of establishment of protein localization protein localization to chromosome, telomeric region establishment of protein localization to organelle protein localization to chromosome regulation of establishment of protein localization to telomere macromolecule localization protein localization to organelle symbiont-mediated disruption of host anatomical structure biological process involved in interspecies interaction between organisms symbiont-mediated disruption of host cell PML body disruption of anatomical structure in another organism symbiont-mediated disruption of host cellular anatomical structure regulation of telomere maintenance regulation of cellular component organization telomere organization chromosome organization regulation of chromosome organization regulation of organelle organization telomere maintenance organelle organization telomere capping regulation of telomere capping regulation of DNA metabolic process signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication negative regulation of TORC1 signaling regulation of intracellular signal transduction negative regulation of TOR signaling signal transduction regulation of TORC1 signaling TOR signaling regulation of signaling regulation of TOR signaling negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus regulation of cell communication TORC1 signaling monosaccharide metabolic process negative regulation of small molecule metabolic process gluconeogenesis negative regulation of gluconeogenesis regulation of small molecule metabolic process small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process negative regulation of carbohydrate metabolic process carbohydrate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process hexose biosynthetic process regulation of gluconeogenesis regulation of carbohydrate biosynthetic process glucose metabolic process signal transduction by p53 class mediator regulation of signal transduction by p53 class mediator	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex membraneless organelle intracellular membraneless organelle chromosome nuclear body PML body
B	p53 peptide	TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding histone deacetylase binding enzyme binding enzyme regulator activity molecular function regulator activity histone deacetylase regulator activity TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding histone deacetylase binding enzyme binding enzyme regulator activity molecular function regulator activity histone deacetylase regulator activity protein-folding chaperone binding chromatin binding promoter-specific chromatin binding DNA binding nucleic acid binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity protein phosphatase binding phosphatase binding protein phosphatase 2A binding protease binding MDM2/MDM4 family protein binding molecular function activator activity sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding transcription regulatory region nucleic acid binding mRNA 3'-UTR binding RNA binding mRNA binding cation binding transition metal ion binding copper ion binding ion binding metal ion binding small molecule binding core promoter sequence-specific DNA binding 14-3-3 protein binding cis-regulatory region sequence-specific DNA binding protein tyrosine kinase binding kinase binding signaling receptor binding receptor tyrosine kinase binding protein kinase binding identical protein binding p53 binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein heterodimerization activity protein dimerization activity molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity ATP-dependent DNA/DNA annealing activity single-stranded DNA binding catalytic activity, acting on a nucleic acid ATP-dependent activity ATP-dependent activity, acting on DNA DNA/DNA annealing activity catalytic activity, acting on DNA annealing activity catalytic activity zinc ion binding disordered domain specific binding protein domain specific binding	catabolic process regulation of cellular process macroautophagy autophagy negative regulation of biological process regulation of autophagy mitophagy negative regulation of cellular process regulation of autophagy of mitochondrion process utilizing autophagic mechanism negative regulation of catabolic process regulation of biological process negative regulation of metabolic process negative regulation of autophagy of mitochondrion catabolic process regulation of cellular process macroautophagy autophagy negative regulation of biological process regulation of autophagy mitophagy negative regulation of cellular process regulation of autophagy of mitochondrion process utilizing autophagic mechanism negative regulation of catabolic process regulation of biological process negative regulation of metabolic process negative regulation of autophagy of mitochondrion biological regulation regulation of mitophagy regulation of catabolic process negative regulation of mitophagy negative regulation of macroautophagy regulation of macroautophagy negative regulation of autophagy cellular process metabolic process regulation of metabolic process autophagy of mitochondrion regulation of protein stability regulation of biological quality protein stabilization positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling positive regulation of macromolecule metabolic process cellular component organization or biogenesis positive regulation of cellular process transcription initiation at RNA polymerase II promoter regulation of biosynthetic process epigenetic regulation of gene expression primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of gene expression biosynthetic process positive regulation of gene expression transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process macromolecule metabolic process membrane organization transport apoptotic mitochondrial changes cell death establishment of localization mitochondrial membrane organization localization organelle organization regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process apoptotic process regulation of mitochondrial membrane permeability programmed cell death mitochondrion organization mitochondrial transport protein localization cellular localization cellular macromolecule localization macromolecule localization cellular response to stimulus response to stimulus signaling signal transduction by p53 class mediator intracellular signal transduction cell communication apoptotic signaling pathway intrinsic apoptotic signaling pathway by p53 class mediator signal transduction intrinsic apoptotic signaling pathway multicellular organismal process cellular developmental process regulation of developmental process cell development regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis negative regulation of glial cell proliferation regulation of cell development regulation of nervous system development neurogenesis multicellular organism development negative regulation of neurogenesis regulation of glial cell proliferation gliogenesis cell differentiation anatomical structure development regulation of multicellular organismal process negative regulation of nervous system development negative regulation of cell differentiation system development developmental process regulation of multicellular organismal development negative regulation of cell population proliferation cell population proliferation negative regulation of developmental process nervous system development negative regulation of gliogenesis negative regulation of cell development regulation of cell population proliferation glial cell proliferation negative regulation of multicellular organismal process response to stress response to ischemia response to chemical response to antibiotic response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus replicative senescence cell cycle cell cycle process transcription preinitiation complex assembly regulation of primary metabolic process cellular component biogenesis regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process RNA polymerase II preinitiation complex assembly regulation of DNA-templated transcription regulation of RNA polymerase II transcription preinitiation complex assembly positive regulation of cellular component organization regulation of cellular component organization positive regulation of DNA-templated transcription protein-DNA complex organization positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly protein-containing complex assembly regulation of RNA biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II protein-DNA complex assembly regulation of cellular component biogenesis positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II head development animal organ development brain development cerebellum development central nervous system development metencephalon development hindbrain development tissue remodeling regulation of tissue remodeling positive regulation of miRNA transcription positive regulation of miRNA metabolic process miRNA transcription regulation of miRNA metabolic process miRNA metabolic process regulation of miRNA transcription regulation of stem cell proliferation negative regulation of stem cell proliferation stem cell proliferation biological process involved in interspecies interaction between organisms response to type II interferon response to cytokine cytokine-mediated signaling pathway cellular response to type II interferon response to biotic stimulus interferon-mediated signaling pathway innate immune response cellular response to cytokine stimulus response to external biotic stimulus cell surface receptor signaling pathway immune response response to other organism defense response type II interferon-mediated signaling pathway defense response to symbiont response to external stimulus response to peptide immune system process defense response to other organism hemopoiesis cell activation mononuclear cell differentiation T cell lineage commitment lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation T cell differentiation cell fate commitment leukocyte differentiation reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process fibroblast proliferation DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response DNA repair cellular response to chemical stimulus cellular response to xenobiotic stimulus response to xenobiotic stimulus cellular response to biotic stimulus ER overload response ER-nucleus signaling pathway response to endoplasmic reticulum stress negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process multicellular organism growth developmental growth growth regulation of amide metabolic process negative regulation of small molecule metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy negative regulation of nucleotide metabolic process regulation of small molecule metabolic process regulation of phosphate metabolic process regulation of nucleotide metabolic process regulation of pentose-phosphate shunt pentose-phosphate shunt phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process negative regulation of pentose-phosphate shunt regulation of phosphorus metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process glucose 6-phosphate metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process regulation of NADP metabolic process amide metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process generation of precursor metabolites and energy purine-containing compound metabolic process NADP metabolic process NADPH regeneration organophosphate metabolic process negative regulation of phosphorus metabolic process negative regulation of DNA replication DNA replication negative regulation of DNA metabolic process regulation of DNA metabolic process regulation of DNA replication response to osmotic stress response to salt stress cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway somitogenesis epithelium development chordate embryonic development segmentation anterior/posterior pattern specification pattern specification process embryo development tissue development regionalization anatomical structure morphogenesis embryo development ending in birth or egg hatching somite development anatomical structure formation involved in morphogenesis negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process fibroblast apoptotic process regulation of fibroblast apoptotic process negative regulation of ATP-dependent activity regulation of ATP-dependent activity regulation of molecular function regulation of catalytic activity negative regulation of molecular function negative regulation of helicase activity negative regulation of catalytic activity regulation of signal transduction regulation of intrinsic apoptotic signaling pathway regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator regulation of signaling regulation of response to stimulus regulation of cell communication regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to decreased oxygen levels intrinsic apoptotic signaling pathway in response to hypoxia response to hypoxia response to oxygen levels negative regulation of proteolysis regulation of protein metabolic process regulation of proteolysis proteolysis protein metabolic process negative regulation of protein metabolic process positive regulation of cardiac muscle cell apoptotic process positive regulation of programmed cell death muscle cell apoptotic process positive regulation of striated muscle cell apoptotic process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process positive regulation of apoptotic process cardiac muscle cell apoptotic process positive regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process leukocyte apoptotic process positive regulation of thymocyte apoptotic process lymphocyte apoptotic process thymocyte apoptotic process regulation of T cell apoptotic process positive regulation of leukocyte apoptotic process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process positive regulation of lymphocyte apoptotic process positive regulation of T cell apoptotic process regulation of thymocyte apoptotic process T cell apoptotic process positive regulation of reactive oxygen species metabolic process small GTPase-mediated signal transduction Ras protein signal transduction intracellular signaling cassette immune system development hematopoietic or lymphoid organ development bone marrow development skeletal system development bone development response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to UV-C response to UV-C cellular response to light stimulus cellular response to abiotic stimulus cellular response to UV neuron apoptotic process regulation of cellular senescence cellular senescence positive regulation of cellular senescence response to gamma radiation necroptotic process programmed necrotic cell death cell activation involved in immune response leukocyte proliferation immune effector process T cell proliferation involved in immune response T cell activation involved in immune response mononuclear cell proliferation lymphocyte proliferation leukocyte activation involved in immune response lymphocyte activation involved in immune response T cell proliferation oligodendrocyte apoptotic process glial cell apoptotic process regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process peptidyl-amino acid modification protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of peptidyl-tyrosine phosphorylation macromolecule modification regulation of phosphorylation peptidyl-tyrosine phosphorylation neuroblast proliferation generation of neurons neural precursor cell proliferation cell cycle G2/M phase transition regulation of cell cycle phase transition regulation of cell cycle process regulation of cell cycle G2/M phase transition cell cycle phase transition regulation of cell cycle positive regulation of mitochondrial membrane permeability positive regulation of membrane permeability B cell activation B cell lineage commitment B cell differentiation positive regulation of organelle organization regulation of release of cytochrome c from mitochondria positive regulation of release of cytochrome c from mitochondria regulation of organelle organization release of cytochrome c from mitochondria regulation of mitochondrion organization protein complex oligomerization protein tetramerization viral process cellular response to nutrient levels response to nutrient levels response to starvation cellular response to glucose starvation cellular response to starvation negative regulation of neural precursor cell proliferation regulation of neuroblast proliferation negative regulation of neuroblast proliferation regulation of neural precursor cell proliferation positive regulation of neuron apoptotic process regulation of neuron apoptotic process cellular response to ionizing radiation regulation of growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth establishment of protein localization nitrogen compound transport nucleocytoplasmic transport nuclear transport intracellular transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport DNA damage checkpoint signaling negative regulation of cell cycle regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cell cycle phase transition negative regulation of G1/S transition of mitotic cell cycle mitotic G1/S transition checkpoint signaling negative regulation of mitotic cell cycle phase transition negative regulation of cell cycle G1/S phase transition DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic G1 DNA damage checkpoint signaling mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle signal transduction in response to DNA damage G1/S transition of mitotic cell cycle mitotic cell cycle phase transition regulation of execution phase of apoptosis positive regulation of execution phase of apoptosis execution phase of apoptosis in utero embryonic development T cell differentiation in thymus heart development cardiac chamber morphogenesis heart morphogenesis circulatory system development cardiac septum development cardiac septum morphogenesis cardiac chamber development animal organ morphogenesis embryonic organ development mRNA transcription mRNA metabolic process negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of cell communication regulation of transforming growth factor beta receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway rhythmic process entrainment of circadian clock circadian rhythm regulation of circadian rhythm photoperiodism entrainment of circadian clock by photoperiod behavior circadian behavior rhythmic behavior rRNA transcription rRNA metabolic process regulation of fibroblast proliferation negative regulation of fibroblast proliferation positive regulation of cell communication positive regulation of signal transduction positive regulation of apoptotic signaling pathway positive regulation of response to stimulus positive regulation of intracellular signal transduction positive regulation of intrinsic apoptotic signaling pathway positive regulation of signaling cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway response to tumor necrosis factor regulation of programmed necrotic cell death positive regulation of programmed necrotic cell death post-transcriptional regulation of gene expression RNA processing regulation of miRNA processing miRNA-mediated post-transcriptional gene silencing negative regulation of gene expression negative regulation of miRNA-mediated gene silencing post-transcriptional gene silencing miRNA processing negative regulation of post-transcriptional gene silencing regulation of miRNA-mediated gene silencing negative regulation of post-transcriptional gene silencing by regulatory ncRNA regulation of regulatory ncRNA processing regulation of gene silencing by regulatory ncRNA regulation of post-transcriptional gene silencing by regulatory ncRNA negative regulation of miRNA processing negative regulation of gene silencing by regulatory ncRNA regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of post-transcriptional gene silencing negative regulation of G1 to G0 transition regulation of G1 to G0 transition G1 to G0 transition cellular response to nitrogen compound response to oxygen-containing compound response to nitrogen compound response to actinomycin D cellular response to oxygen-containing compound cellular response to actinomycin D cellular response to antibiotic cellular response to oxidative stress cellular response to chemical stress oxidative stress-induced premature senescence response to oxidative stress stress-induced premature senescence cellular response to gamma radiation chromosome organization embryonic morphogenesis gastrulation regulation of cellular response to stress DNA damage response, signal transduction by p53 class mediator regulation of response to stress regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of telomere maintenance telomere organization negative regulation of telomere maintenance via telomerase regulation of DNA biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening negative regulation of chromosome organization negative regulation of cellular component organization regulation of chromosome organization regulation of telomere maintenance via telomere lengthening telomere maintenance DNA biosynthetic process negative regulation of DNA biosynthetic process regulation of telomere maintenance negative regulation of telomere maintenance via telomere lengthening telomere maintenance via telomerase regulation of telomere maintenance via telomerase negative regulation of organelle organization monosaccharide metabolic process glucose catabolic process to lactate via pyruvate energy derivation by oxidation of organic compounds oxoacid metabolic process negative regulation of fermentation organic acid metabolic process fermentation lactate metabolic process glycolytic fermentation regulation of glucose catabolic process to lactate via pyruvate regulation of glucose metabolic process negative regulation of carbohydrate metabolic process hexose catabolic process carboxylic acid metabolic process hexose metabolic process glucose catabolic process monocarboxylic acid metabolic process negative regulation of glucose catabolic process to lactate via pyruvate glucose catabolic process to lactate monosaccharide catabolic process small molecule catabolic process regulation of fermentation glucose metabolic process determination of adult lifespan stem cell differentiation hematopoietic stem cell differentiation hematopoietic progenitor cell differentiation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress mitochondrial genome maintenance mitochondrial DNA metabolic process mitochondrial DNA repair intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage double-strand break repair	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen germ cell nucleus protein-containing complex replication fork chromosome site of double-strand break site of DNA damage mitochondrion mitochondrial matrix transcription regulator complex chromatin nuclear periphery nuclear matrix centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton nucleoplasm transcription repressor complex endoplasmic reticulum endomembrane system nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR028889	Ubiquitin specific protease domain	Domain
A	IPR018200	Ubiquitin specific protease, conserved site	Conserved Site
A	IPR024729	Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain	Domain
A	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
A	IPR002083	MATH/TRAF domain	Domain
A	IPR029346	Ubiquitin carboxyl-terminal hydrolase, C-terminal	Domain
A	IPR050164	Ubiquitin carboxyl-terminal hydrolases	Family
A	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	Domain
A	IPR008974	TRAF-like	Homologous Superfamily
B	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain superfamily	Homologous Superfamily
B	IPR002117	p53 tumour suppressor family	Family
B	IPR013872	p53 transactivation domain	Domain
B	IPR036674	p53-like tetramerisation domain superfamily	Homologous Superfamily
B	IPR011615	p53, DNA-binding domain	Domain
B	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
B	IPR010991	p53, tetramerisation domain	Domain
B	IPR040926	Cellular tumor antigen p53, transactivation domain 2	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q93009	urinary bladder cancer prostate cancer Hao-Fountain syndrome Prostatic Neoplasms intellectual disability urinary bladder neoplasm
B	Pharos: P04637	Li-Fraumeni syndrome melanoma cholangiocarcinoma choroid plexus papilloma angiosarcoma B-cell chronic lymphocytic leukemia adrenal cortex carcinoma esophageal cancer adrenocortical carcinoma, hereditary malignant glioma renal cell carcinoma urinary bladder cancer skin basal cell carcinoma squamous cell carcinoma psoriasis Li-Fraumeni syndrome melanoma cholangiocarcinoma choroid plexus papilloma angiosarcoma B-cell chronic lymphocytic leukemia adrenal cortex carcinoma esophageal cancer adrenocortical carcinoma, hereditary malignant glioma renal cell carcinoma urinary bladder cancer skin basal cell carcinoma squamous cell carcinoma psoriasis osteosarcoma head and neck squamous cell carcinoma esophageal squamous cell carcinoma small cell lung carcinoma amyotrophic lateral sclerosis nasopharyngeal carcinoma hypertensive disorder T-cell non-Hodgkin lymphoma Balkan nephropathy adenoma choroid plexus carcinoma hypertrophic cardiomyopathy colorectal cancer kidney Wilms tumor glioblastoma skin neoplasm gallbladder cancer thymoma cancer malignant mesothelioma transitional cell carcinoma non-small cell lung carcinoma cutaneous melanoma esophageal adenocarcinoma primary cutaneous T-cell non-Hodgkin lymphoma breast adenocarcinoma male infertility Neoplasm Metastasis thyroid gland carcinoma keratosis salivary gland adenoid cystic carcinoma astrocytic tumor giant cell glioblastoma carotid artery disease sarcomatoid carcinoma central nervous system cancer ovarian cancer Li-Fraumeni syndrome 1 Sezary syndrome liver cancer papillary renal cell carcinoma small cell carcinoma essential thrombocythemia spindle cell sarcoma microcystic adenoma hepatocellular carcinoma brain ischemia clear cell adenocarcinoma familial pancreatic carcinoma breast cancer collecting duct carcinoma follicular thyroid adenoma thymic carcinoma gastric cancer thyroid adenoma carcinoma tubular adenocarcinoma demyelinating disease sarcomatoid renal cell carcinoma gliosarcoma penile neoplasm adrenal gland cancer polyploidy lung cancer exocrine pancreatic carcinoma mixed glioma myelodysplastic syndrome prostate cancer female infertility breast carcinoma malignant colon neoplasm intrahepatic cholangiocarcinoma vulvar lichen sclerosus sarcoma adenocarcinoma schizophrenia granular cell carcinoma adenoid cystic carcinoma skin cancer papillary adenoma chromophobe renal cell carcinoma lung carcinoma brain glioma mouth disease chronic obstructive pulmonary disease eye disease prostate disease breast disease colorectal adenocarcinoma pulmonary emphysema malignant ependymoma gallbladder neoplasm thymus neoplasm renal carcinoma uterine corpus leiomyoma neuroblastoma acute kidney failure cribriform carcinoma triple-negative breast carcinoma oligodendroglioma acute megakaryoblastic leukemia glioma susceptibility 1 undifferentiated carcinoma granulomatous slack skin disease urinary bladder neoplasm ovarian neoplasm skin disease benign neoplasm of pancreas head and neck carcinoma childhood acute lymphoblastic leukemia bile duct cancer medulloblastoma penile cancer polycystic ovary syndrome lung benign neoplasm bone osteosarcoma lung disease hereditary breast ovarian cancer syndrome primitive neuroectodermal tumor lymphatic system disease subependymal giant cell astrocytoma nasopharyngeal carcinoma, susceptibility to, 1 Burkitt lymphoma neoplasm of esophagus intestinal disease ischemic disease congenital anemia uterine disease neurodegenerative disease cribriform carcinoma of breast SAPHO syndrome atypical teratoid rhabdoid tumor oral cavity neoplasm acute myeloid leukemia ovarian carcinoma Li-Fraumeni syndrome 2 basal cell carcinoma, susceptibility to, 7 malignant pancreatic neoplasm Hantavirus hemorrhagic fever with renal syndrome, Puumala virus type urogenital neoplasm cervical cancer pancreatic neoplasm epithelioid sarcoma benign urinary system neoplasm head and neck neoplasm uterine cervix carcinoma in situ papilloma liver neoplasm esophageal disease bone disease hematopoietic and lymphoid system neoplasm adult hepatocellular carcinoma brain disease chromosome 17p deletion stomach disease hereditary diffuse gastric adenocarcinoma clear cell renal carcinoma nasopharyngeal neoplasm IgA glomerulonephritis colonic neoplasm anemia colorectal carcinoma pustulosis palmaris et plantaris gastric neoplasm thyroid cancer rheumatoid arthritis kidney disease large cell medulloblastoma autoimmune disease glioma urinary bladder disease ovarian disease endometriosis benign colon neoplasm head and neck cancer cervical carcinoma adrenal carcinoma liver disease skin pigmented basal cell carcinoma choroid plexus cancer pilocytic astrocytoma bone marrow disease metabolic syndrome X hepatoblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.