2DUD | pdb_00002dud

Crystal structure of human mitochondrial single-stranded DNA-binding protein(hmtSSB)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2duda_	All beta proteins	OB-fold	Nucleic acid-binding proteins	Single strand DNA-binding domain, SSB	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2dudb_	All beta proteins	OB-fold	Nucleic acid-binding proteins	Single strand DNA-binding domain, SSB	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nucleic acid-binding proteins	8041927	3000135	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleic acid-binding proteins	8041927	3000135	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SSB	e2dudA1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: SSB	ECOD (1.6)
B	SSB	e2dudB1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: SSB	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
B	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00436	Single-strand binding protein family (SSB)	Single-strand binding protein family	This family includes single stranded binding proteins and also the primosomal replication protein N (PriB). PriB forms a complex with PriA, PriC and ssDNA.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Single-stranded DNA-binding protein	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity chromatin binding RNA binding nucleic acid binding DNA binding single-stranded DNA binding	positive regulation of mitochondrial DNA metabolic process positive regulation of organelle organization regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization positive regulation of DNA replication positive regulation of biological process mitochondrial genome maintenance positive regulation of mitochondrial DNA replication mitochondrial DNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process cellular component organization positive regulation of metabolic process positive regulation of mitochondrial DNA metabolic process positive regulation of organelle organization regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization positive regulation of DNA replication positive regulation of biological process mitochondrial genome maintenance positive regulation of mitochondrial DNA replication mitochondrial DNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process cellular component organization positive regulation of metabolic process positive regulation of macromolecule metabolic process cellular component organization or biogenesis regulation of nucleobase-containing compound metabolic process positive regulation of cellular process mitochondrion organization regulation of biological process positive regulation of nucleobase-containing compound metabolic process DNA-templated DNA replication biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of organelle organization organelle organization DNA replication positive regulation of DNA metabolic process mitochondrial DNA replication regulation of mitochondrion organization regulation of DNA-templated DNA replication positive regulation of DNA-templated DNA replication metabolic process cellular process regulation of mitochondrial DNA replication macromolecule metabolic process regulation of metabolic process regulation of mitochondrial DNA metabolic process regulation of DNA metabolic process regulation of DNA replication protein-containing complex organization protein homotetramerization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization positive regulation of molecular function regulation of molecular function regulation of ATP-dependent activity positive regulation of helicase activity positive regulation of ATP-dependent activity regulation of catalytic activity positive regulation of catalytic activity	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle membrane-enclosed lumen intracellular membraneless organelle nucleoid mitochondrial matrix intracellular organelle lumen organelle lumen membraneless organelle mitochondrial nucleoid nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011344	Single-stranded DNA-binding protein	Family
A, B	IPR000424	Primosome PriB/single-strand DNA-binding	Family
A, B	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q04837	Arsenic Poisoning tuberculosis dermatomyositis lung cancer medulloblastoma ovarian cancer plasma cell myeloma breast carcinoma glioblastoma lymphoplasmacytic lymphoma pancreatic intraductal papillary-mucinous carcinoma skin disease hepatocellular carcinoma malignant glioma osteosarcoma Arsenic Poisoning tuberculosis dermatomyositis lung cancer medulloblastoma ovarian cancer plasma cell myeloma breast carcinoma glioblastoma lymphoplasmacytic lymphoma pancreatic intraductal papillary-mucinous carcinoma skin disease hepatocellular carcinoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.