2CCL

THE S45A, T46A MUTANT OF THE TYPE I COHESIN-DOCKERIN COMPLEX FROM THE CELLULOSOME OF CLOSTRIDIUM THERMOCELLUM

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ccla2	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Carbohydrate-binding domain	Cellulose-binding domain family III	automated matches	(Acetivibrio thermocellus ) [TaxId: 1515 ],	SCOPe (2.08)
A	d2ccla3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Acetivibrio thermocellus ) [TaxId: 1515 ],	SCOPe (2.08)
C	d2cclc2	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Carbohydrate-binding domain	Cellulose-binding domain family III	automated matches	(Acetivibrio thermocellus ) [TaxId: 1515 ],	SCOPe (2.08)
C	d2cclc3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Acetivibrio thermocellus ) [TaxId: 1515 ],	SCOPe (2.08)
D	d2ccld_	All alpha proteins	Type I dockerin domain	Type I dockerin domain	Type I dockerin domain	automated matches	(Acetivibrio thermocellus ) [TaxId: 1515 ],	SCOPe (2.08)
B	d2cclb1	All alpha proteins	Type I dockerin domain	Type I dockerin domain	Type I dockerin domain	Endo-1,4-beta-xylanase Y	(Acetivibrio thermocellus ) [TaxId: 1515 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Type I dockerin domain	8037491	3001894	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Type I dockerin domain	8037491	3001894	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Cohesin	e2cclA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Cohesin	ECOD (1.6)
C	Cohesin	e2cclC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Cohesin	ECOD (1.6)
D	Dockerin_1	e2cclD1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: Type I dockerin domain	F: Dockerin_1	ECOD (1.6)
B	Dockerin_1	e2cclB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: Type I dockerin domain	F: Dockerin_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.680	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
C	2.60.40.680	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
D	1.10.1330.10	Mainly Alpha	Orthogonal Bundle	Type 1 dockerin domain	Dockerin domain	CATH (4.3.0)
B	1.10.1330.10	Mainly Alpha	Orthogonal Bundle	Type 1 dockerin domain	Dockerin domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00963	Cohesin domain (Cohesin)	Cohesin domain	Cohesin domains interact with a complementary domain, termed the dockerin domain. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome [1].	Domain
B, D	PF00404	Dockerin type I domain (Dockerin_1)	Dockerin type I domain	The dockerin repeat is the binding partner of the cohesin domain Pfam:PF00963. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome [1]. The dockerin repeats, each bearing homology to the EF-hand calciu ...	The dockerin repeat is the binding partner of the cohesin domain Pfam:PF00963. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome [1]. The dockerin repeats, each bearing homology to the EF-hand calcium-binding loop bind calcium [2]. This family contains two copies of the repeat.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	CELLULOSOMAL SCAFFOLDING PROTEIN A	binding polysaccharide binding cellulose binding carbohydrate binding hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity	cellular component organization cell wall organization or biogenesis cell wall organization cellular process cellular component organization or biogenesis external encapsulating structure organization carbohydrate metabolic process catabolic process glucan catabolic process beta-glucan metabolic process carbohydrate catabolic process primary metabolic process macromolecule catabolic process polysaccharide metabolic process cellular component organization cell wall organization or biogenesis cell wall organization cellular process cellular component organization or biogenesis external encapsulating structure organization carbohydrate metabolic process catabolic process glucan catabolic process beta-glucan metabolic process carbohydrate catabolic process primary metabolic process macromolecule catabolic process polysaccharide metabolic process glucan metabolic process beta-glucan catabolic process polysaccharide catabolic process metabolic process cellulose catabolic process macromolecule metabolic process cellulose metabolic process	cellular anatomical structure extracellular region
B, D	ENDO-1,4-BETA-XYLANASE Y	xylanase activity hydrolase activity, acting on glycosyl bonds endo-1,4-beta-xylanase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity	carbohydrate metabolic process xylan catabolic process catabolic process hemicellulose metabolic process cell wall organization or biogenesis carbohydrate catabolic process hemicellulose catabolic process primary metabolic process macromolecule catabolic process cell wall macromolecule catabolic process xylan metabolic process polysaccharide metabolic process polysaccharide catabolic process metabolic process carbohydrate metabolic process xylan catabolic process catabolic process hemicellulose metabolic process cell wall organization or biogenesis carbohydrate catabolic process hemicellulose catabolic process primary metabolic process macromolecule catabolic process cell wall macromolecule catabolic process xylan metabolic process polysaccharide metabolic process polysaccharide catabolic process metabolic process cellular process macromolecule metabolic process cell wall polysaccharide metabolic process cell wall macromolecule metabolic process cell wall polysaccharide catabolic process	cellulosome cellular anatomical structure extracellular organelle extracellular region organelle membraneless organelle extracellular membraneless organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR002105	Dockerin type I repeat	Repeat
A, C	IPR036966	Carbohydrate-binding module 3 superfamily	Homologous Superfamily
A, C	IPR016134	Dockerin domain	Domain
A, C	IPR001956	Carbohydrate-binding module 3	Domain
A, C	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, C	IPR008965	CBM2/CBM3, carbohydrate-binding domain superfamily	Homologous Superfamily
A, C	IPR008969	Carboxypeptidase-like, regulatory domain superfamily	Homologous Superfamily
A, C	IPR002102	Cellulosome anchoring protein, cohesin domain	Domain
A, C	IPR036439	Dockerin domain superfamily	Homologous Superfamily
B, D	IPR002105	Dockerin type I repeat	Repeat
B, D	IPR003305	Carbohydrate-binding, CenC-like	Domain
B, D	IPR016134	Dockerin domain	Domain
B, D	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
B, D	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
B, D	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
B, D	IPR031158	Glycosyl hydrolases family 10, active site	Active Site
B, D	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
B, D	IPR000801	Esterase-like	Family
B, D	IPR044846	Glycoside hydrolase family 10	Family
B, D	IPR036439	Dockerin domain superfamily	Homologous Superfamily
B, D	IPR001000	Glycoside hydrolase family 10 domain	Domain