2C6Q

Crystal structure of human guanosine monophosphate reductase 2 GMPR2 in complex with IMP and NADPH

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2c6qa1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2c6qa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2c6qb1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2c6qb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2c6qd1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2c6qd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d2c6qe1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d2c6qe2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d2c6qf1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d2c6qf2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d2c6qg1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d2c6qg2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d2c6qh1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d2c6qh2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2c6qc1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2c6qc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Inosine monophosphate dehydrogenase (IMPDH)	8081557	3000263	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Inosine monophosphate dehydrogenase (IMPDH)	8081557	3000263	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Inosine monophosphate dehydrogenase (IMPDH)	8081557	3000263	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Inosine monophosphate dehydrogenase (IMPDH)	8081557	3000263	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Inosine monophosphate dehydrogenase (IMPDH)	8081557	3000263	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Inosine monophosphate dehydrogenase (IMPDH)	8081557	3000263	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Inosine monophosphate dehydrogenase (IMPDH)	8081557	3000263	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Inosine monophosphate dehydrogenase (IMPDH)	8081557	3000263	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IMPDH_1st	e2c6qA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
B	IMPDH_1st	e2c6qB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
D	IMPDH_1st	e2c6qD1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
E	IMPDH_1st	e2c6qE1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
F	IMPDH_1st	e2c6qF1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
G	IMPDH_1st	e2c6qG1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
H	IMPDH_1st	e2c6qH1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
C	IMPDH_1st	e2c6qC1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
B	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
D	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
E	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
F	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
G	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
H	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
C	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00478	IMP dehydrogenase / GMP reductase domain (IMPDH)	IMP dehydrogenase / GMP reductase domain	This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains Pfam:PF00571 are inserted in the TIM barrel [2]. This family is a membe ...	This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains Pfam:PF00571 are inserted in the TIM barrel [2]. This family is a member of the common phosphate binding site TIM barrel family.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	GMP REDUCTASE 2	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor oxidoreductase activity oxidoreductase activity, acting on other nitrogenous compounds as donors GMP reductase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding	nucleobase-containing compound metabolic process purine nucleobase metabolic process nucleobase-containing small molecule metabolic process nucleobase metabolic process small molecule metabolic process metabolic process cellular process primary metabolic process purine-containing compound metabolic process nucleoside phosphate metabolic process ribose phosphate metabolic process carbohydrate derivative metabolic process nucleotide metabolic process purine ribonucleoside monophosphate metabolic process nucleobase-containing compound metabolic process purine nucleobase metabolic process nucleobase-containing small molecule metabolic process nucleobase metabolic process small molecule metabolic process metabolic process cellular process primary metabolic process purine-containing compound metabolic process nucleoside phosphate metabolic process ribose phosphate metabolic process carbohydrate derivative metabolic process nucleotide metabolic process purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process ribonucleoside monophosphate metabolic process purine nucleoside monophosphate metabolic process GMP metabolic process phosphate-containing compound metabolic process purine ribonucleotide metabolic process phosphorus metabolic process nucleoside monophosphate metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex GMP reductase complex catalytic complex oxidoreductase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR050139	Guanosine monophosphate reductase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR005993	GMP reductase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001093	IMP dehydrogenase/GMP reductase	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR015875	IMP dehydrogenase / GMP reductase, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: Q9P2T1	adenocarcinoma granular cell carcinoma tubular adenocarcinoma cribriform carcinoma gastric neoplasm language disorder plasma cell myeloma Adenocarcinoma, Basal Cell cribriform carcinoma of breast gastric cancer hereditary diffuse gastric adenocarcinoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.