Annotations: 2ATY

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Sushi/CCP/SCR domain	8032838	3000902	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Sushi/CCP/SCR domain	8032835	3000902	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Sushi/CCP/SCR domain	8032835	3000902	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Sushi/CCP/SCR domain	8032838	3000902	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C1-set	e2atyA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
A	C1-set_1	e2atyA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
A	Sushi	e2atyA4	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
A	Sushi_3	e2atyA3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_3	ECOD (1.6)
B	C1-set	e2atyB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
B	C1-set_1	e2atyB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
B	Sushi	e2atyB4	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
B	Sushi_3	e2atyB3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_3	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00084	Sushi repeat (SCR repeat) (Sushi)	Sushi repeat (SCR repeat)		Domain
A, B	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Complement receptor chimeric conjugate CR2-Ig	binding antigen binding protein binding virus receptor activity exogenous protein binding molecular transducer activity complement receptor activity transmembrane signaling receptor activity signaling receptor activity immune receptor activity complement binding signaling receptor binding immunoglobulin receptor binding DNA binding binding antigen binding protein binding virus receptor activity exogenous protein binding molecular transducer activity complement receptor activity transmembrane signaling receptor activity signaling receptor activity immune receptor activity complement binding signaling receptor binding immunoglobulin receptor binding DNA binding nucleic acid binding identical protein binding protein homodimerization activity protein dimerization activity	regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity B cell mediated immunity leukocyte mediated immunity immunoglobulin mediated immune response adaptive immune response immune effector process membrane organization import into cell transport establishment of localization vesicle-mediated transport cellular component organization localization phagocytosis, engulfment membrane invagination cellular process phagocytosis cellular component organization or biogenesis endocytosis plasma membrane invagination positive regulation of acute inflammatory response to antigenic stimulus regulation of immune effector process regulation of acute inflammatory response to antigenic stimulus positive regulation of leukocyte mediated immunity inflammatory response to antigenic stimulus positive regulation of hypersensitivity positive regulation of inflammatory response positive regulation of adaptive immune response positive regulation of immunoglobulin mediated immune response hypersensitivity regulation of adaptive immune response response to external stimulus regulation of inflammatory response regulation of B cell mediated immunity regulation of leukocyte mediated immunity positive regulation of defense response regulation of acute inflammatory response inflammatory response positive regulation of type I hypersensitivity regulation of type I hypersensitivity regulation of defense response regulation of response to external stimulus positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of acute inflammatory response positive regulation of B cell mediated immunity type I hypersensitivity positive regulation of response to external stimulus regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains response to stress regulation of response to stress regulation of immunoglobulin mediated immune response positive regulation of immune effector process acute inflammatory response regulation of hypersensitivity defense response regulation of inflammatory response to antigenic stimulus acute inflammatory response to antigenic stimulus positive regulation of inflammatory response to antigenic stimulus regulation of lymphocyte mediated immunity myeloid leukocyte mediated immunity antibody-dependent cellular cytotoxicity leukocyte mediated cytotoxicity type II hypersensitivity type IIa hypersensitivity cell killing developmental process multicellular organismal process cellular developmental process hemopoiesis B cell activation cell activation cell development mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation cell differentiation anatomical structure development leukocyte differentiation regulation of myeloid leukocyte mediated immunity regulation of type IIa hypersensitivity regulation of type II hypersensitivity positive regulation of myeloid leukocyte mediated immunity positive regulation of type IIa hypersensitivity positive regulation of type II hypersensitivity humoral immune response complement activation humoral immune response mediated by circulating immunoglobulin complement activation, classical pathway activation of immune response biological process involved in interspecies interaction between organisms response to other organism antibacterial humoral response defense response to symbiont antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus regulation of localization positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization positive regulation of endocytosis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport positive regulation of phagocytosis positive regulation of transport phagocytosis, recognition cell recognition T cell mediated immunity symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction regulation of humoral immune response regulation of humoral immune response mediated by circulating immunoglobulin negative regulation of biological process negative regulation of lymphocyte mediated immunity negative regulation of complement activation, classical pathway negative regulation of B cell mediated immunity negative regulation of immune response negative regulation of immune effector process negative regulation of humoral immune response negative regulation of adaptive immune response negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of immunoglobulin mediated immune response regulation of complement activation, classical pathway regulation of complement activation negative regulation of complement activation negative regulation of response to stimulus negative regulation of humoral immune response mediated by circulating immunoglobulin negative regulation of immune system process negative regulation of leukocyte mediated immunity cell population proliferation B cell proliferation leukocyte proliferation mononuclear cell proliferation lymphocyte proliferation complement activation, alternative pathway innate immune response cellular response to stimulus signaling response to cytokine cytokine-mediated signaling pathway cell communication interferon-mediated signaling pathway cellular response to type I interferon cellular response to cytokine stimulus signal transduction cell surface receptor signaling pathway response to peptide response to chemical type I interferon-mediated signaling pathway response to type I interferon	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex extracellular region extracellular space immunoglobulin complex, circulating immunoglobulin complex intracellular anatomical structure cytoplasm cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex extracellular region extracellular space immunoglobulin complex, circulating immunoglobulin complex intracellular anatomical structure cytoplasm extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B	IPR050380	Immune Recognition and Response Modulators	Family
A, B	IPR003597	Immunoglobulin C1-set	Domain
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR007110	Immunoglobulin-like domain	Domain
A, B	IPR051277	SEZ6/CSMD/C4BPB Neuronal & Immune Regulators	Family
A, B	IPR000436	Sushi/SCR/CCP domain	Domain
A, B	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P20023	common variable immunodeficiency systemic lupus erythematosus agammaglobulinemia immunodeficiency, common variable, 7 Acquired Hypogammaglobulinemia B cell deficiency immunodeficiency, common variable, 2 interstitial cystitis lupus erythematosus lymphoplasmacytic lymphoma osteosarcoma systemic lupus erythematosus, susceptibility to, 9 nasopharyngeal carcinoma Sjogren syndrome ulcerative colitis common variable immunodeficiency systemic lupus erythematosus agammaglobulinemia immunodeficiency, common variable, 7 Acquired Hypogammaglobulinemia B cell deficiency immunodeficiency, common variable, 2 interstitial cystitis lupus erythematosus lymphoplasmacytic lymphoma osteosarcoma systemic lupus erythematosus, susceptibility to, 9 nasopharyngeal carcinoma Sjogren syndrome ulcerative colitis Alzheimer disease hematologic disease lung adenocarcinoma lymphatic system disease non-small cell lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.