1WHB | pdb_00001whb

Solution structure of the Rhodanese-like domain in human ubiquitin specific protease 8 (UBP8)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1whba1	Alpha and beta proteins (a/b)	Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	Ubiquitin carboxyl-terminal hydrolase 8, USP8	Ubiquitin carboxyl-terminal hydrolase 8, USP8	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1whba3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1whba2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Rhodanese/Cell cycle control phosphatase	8042088	3000320	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e1whbA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Rhodanese/Cell cycle control phosphatase	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.250.10	Alpha Beta	3-Layer(aba) Sandwich	Oxidized Rhodanese	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00581	Rhodanese-like domain (Rhodanese)	Rhodanese-like domain	Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	KIAA0055	ubiquitin-like protein peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity K48-linked deubiquitinase activity catalytic activity deubiquitinase activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity K63-linked deubiquitinase activity SH3 domain binding protein binding binding ubiquitin-like protein peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity K48-linked deubiquitinase activity catalytic activity deubiquitinase activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity K63-linked deubiquitinase activity SH3 domain binding protein binding binding protein domain specific binding cysteine-type deubiquitinase activity cell adhesion molecule binding cadherin binding	mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization positive regulation of amyloid fibril formation positive regulation of protein metabolic process mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization positive regulation of amyloid fibril formation positive regulation of protein metabolic process positive regulation of biological process regulation of amyloid fibril formation amyloid fibril formation regulation of primary metabolic process cellular component organization positive regulation of metabolic process positive regulation of macromolecule metabolic process cellular component organization or biogenesis protein metabolic process positive regulation of cellular process regulation of biological process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process positive regulation of supramolecular fiber organization regulation of supramolecular fiber organization metabolic process macromolecule metabolic process supramolecular fiber organization regulation of metabolic process cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus response to nerve growth factor response to growth factor protein deubiquitination protein K63-linked deubiquitination protein modification by small protein removal macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation or removal cellular response to stimulus response to ketone response to lipid response to hormone response to steroid hormone cellular response to ketone cellular response to steroid hormone stimulus cellular response to hormone stimulus cellular response to dexamethasone stimulus response to glucocorticoid cellular response to glucocorticoid stimulus response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to corticosteroid stimulus response to corticosteroid cellular response to chemical stimulus response to chemical cellular response to lipid response to dexamethasone small GTPase-mediated signal transduction signaling Ras protein signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction catabolic process modulation of chemical synaptic transmission macromolecule catabolic process regulation of protein catabolic process at postsynapse, modulating synaptic transmission synaptic signaling postsynaptic modulation of chemical synaptic transmission trans-synaptic signaling regulation of signaling cell-cell signaling protein catabolic process regulation of catabolic process chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of protein catabolic process regulation of protein stability regulation of biological quality protein K48-linked deubiquitination protein localization regulation of localization cellular localization regulation of protein localization localization regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein catabolic process in the vacuole negative regulation of biological process lysosomal protein catabolic process negative regulation of protein catabolic process in the vacuole negative regulation of protein catabolic process negative regulation of cellular process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process protein catabolic process in the vacuole negative regulation of metabolic process negative regulation of lysosomal protein catabolic process regulation of lysosomal protein catabolic process positive regulation of cell communication positive regulation of signal transduction regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway cell surface receptor signaling pathway regulation of Wnt signaling pathway regulation of response to stimulus positive regulation of signaling proteolysis vesicle organization organelle organization endosome organization endomembrane system organization	midbody cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane synapse cell junction glutamatergic synapse membrane-bounded organelle early endosome endosome midbody cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane synapse cell junction glutamatergic synapse membrane-bounded organelle early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle vesicle neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR028889	Ubiquitin specific protease domain	Domain
A	IPR048498	USP8, WW domain	Domain
A	IPR001763	Rhodanese-like domain	Domain
A	IPR018200	Ubiquitin specific protease, conserved site	Conserved Site
A	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
A	IPR050185	Ubiquitin carboxyl-terminal hydrolase	Family
A	IPR036873	Rhodanese-like domain superfamily	Homologous Superfamily
A	IPR015063	USP8 dimerisation domain	Domain
A	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P40818	Cushing disease due to pituitary adenoma ACTH-dependent Cushing syndrome acne DOID:12252 osteoarthritis tuberculosis Cushing syndrome hypertensive disorder ovarian cancer ankylosing spondylitis diabetes mellitus

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.