1VCC | pdb_00001vcc

AMINO TERMINAL 9KDA DOMAIN OF VACCINIA VIRUS DNA TOPOISOMERASE I RESIDUES 1-77, EXPERIMENTAL ELECTRON DENSITY FOR RESIDUES 1-77

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1vcca_	Alpha and beta proteins (a+b)	DNA topoisomerase I domain	DNA topoisomerase I domain	Vaccinia DNA topoisomerase I, 9 kDa N-terminal fragment	Vaccinia DNA topoisomerase I, 9 kDa N-terminal fragment	(Vaccinia virus WR ) [TaxId: 10254 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Vaccinia DNA topoisomerase I, 9 kDa N-terminal fragment	8023819	4001939	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DNA topoisomerase I domain	8036199	3000578	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	VirDNA-topo-I_N	e1vccA1	A: a+b two layers	X: DNA topoisomerase I domain (From Topology)	H: DNA topoisomerase I domain (From Topology)	T: DNA topoisomerase I domain	F: VirDNA-topo-I_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.66.10	Alpha Beta	2-Layer Sandwich	Viral Topoisomerase I	DNA topoisomerase I domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09266	Viral DNA topoisomerase I, N-terminal (VirDNA-topo-I_N)	Viral DNA topoisomerase I, N-terminal	Members of this family are predominantly found in viral DNA topoisomerase, and assume a beta(2)-alpha-beta-alpha-beta(2) fold, with a left-handed crossover between strands beta2 and beta3 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA TOPOISOMERASE I	DNA binding binding nucleic acid binding nucleic acid conformation isomerase activity isomerase activity DNA topoisomerase type I (single strand cut, ATP-independent) activity catalytic activity, acting on DNA DNA topoisomerase activity catalytic activity, acting on a nucleic acid catalytic activity macromolecular conformation isomerase activity	chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process cellular component organization nucleobase-containing compound metabolic process DNA topological change organelle organization cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process	virion component

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR035447	DNA topoisomerase I, N-terminal domain superfamily	Homologous Superfamily
A	IPR011010	DNA breaking-rejoining enzyme, catalytic core	Homologous Superfamily
A	IPR001631	DNA topoisomerase I	Family
A	IPR013500	DNA topoisomerase I, catalytic core, eukaryotic-type	Domain
A	IPR014711	DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type	Homologous Superfamily
A	IPR018521	DNA topoisomerase I, active site	Active Site
A	IPR015346	DNA topoisomerase I, N-terminal, viral	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.