1URV | pdb_00001urv

Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1urva_	All alpha proteins	Globin-like	Globin-like	Globins	Cytoglobin	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1urvb_	All alpha proteins	Globin-like	Globin-like	Globins	Cytoglobin	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Globins	8030547	4000551	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Globin-like	8042926	3000554	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Globin-like	8042926	3000554	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Globin	e1urvA1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
B	Globin	e1urvB1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
B	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00042	Globin (Globin)	Globin		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CYTOGLOBIN	oxidoreductase activity catalytic activity peroxidase activity antioxidant activity catalase activity oxidoreductase activity, acting on peroxide as acceptor superoxide dismutase activity oxidoreductase activity, acting on superoxide radicals as acceptor binding carbon monoxide binding small molecule binding oxygen binding fatty acid peroxidase activity oxidoreductase activity, acting on other nitrogenous compounds as donors oxidoreductase activity catalytic activity peroxidase activity antioxidant activity catalase activity oxidoreductase activity, acting on peroxide as acceptor superoxide dismutase activity oxidoreductase activity, acting on superoxide radicals as acceptor binding carbon monoxide binding small molecule binding oxygen binding fatty acid peroxidase activity oxidoreductase activity, acting on other nitrogenous compounds as donors nitrite reductase activity nitric oxide dioxygenase activity, heme protein as donor oxidoreductase activity, acting on a heme group of donors oxygen carrier activity molecular carrier activity tetrapyrrole binding heme binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding	regulation of biosynthetic process regulation of biological process negative regulation of collagen metabolic process regulation of cellular process negative regulation of metabolic process biological regulation negative regulation of biological process collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process negative regulation of collagen biosynthetic process biosynthetic process negative regulation of biosynthetic process negative regulation of cellular process regulation of biosynthetic process regulation of biological process negative regulation of collagen metabolic process regulation of cellular process negative regulation of metabolic process biological regulation negative regulation of biological process collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process negative regulation of collagen biosynthetic process biosynthetic process negative regulation of biosynthetic process negative regulation of cellular process metabolic process cellular process collagen metabolic process regulation of metabolic process nitric oxide metabolic process catabolic process nitric oxide catabolic process reactive nitrogen species metabolic process cellular response to stimulus response to stimulus cellular response to oxidative stress detoxification reactive oxygen species metabolic process cellular response to chemical stress response to superoxide cellular oxidant detoxification cellular response to oxygen radical cellular response to reactive oxygen species cellular response to stress response to stress cellular detoxification response to oxygen-containing compound cellular response to oxygen-containing compound response to reactive oxygen species response to toxic substance removal of superoxide radicals superoxide metabolic process response to oxidative stress cellular response to chemical stimulus response to chemical cellular response to superoxide cellular response to toxic substance response to oxygen radical oxygen transport localization transport gas transport establishment of localization response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process lipid modification primary metabolic process organic acid metabolic process fatty acid oxidation small molecule metabolic process lipid oxidation monocarboxylic acid metabolic process lipid metabolic process multicellular organismal process cell activation regulation of cell activation negative regulation of cell activation fibroblast activation regulation of hepatic stellate cell activation hepatic stellate cell activation regulation of multicellular organismal process negative regulation of multicellular organismal process negative regulation of hepatic stellate cell activation negative regulation of locomotion regulation of cell motility regulation of fibroblast migration fibroblast migration negative regulation of fibroblast migration regulation of locomotion ameboidal-type cell migration regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell projection neuron projection plasma membrane bounded cell projection somatodendritic compartment cell body neuronal cell body membrane-bounded organelle intracellular organelle organelle nucleus cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell projection neuron projection plasma membrane bounded cell projection somatodendritic compartment cell body neuronal cell body membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013314	Globin, lamprey/hagfish type	Family
A, B	IPR009050	Globin-like superfamily	Homologous Superfamily
A, B	IPR012292	Globin/Protoglobin	Homologous Superfamily
A, B	IPR000971	Globin	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q8WWM9	Liver Cirrhosis, Experimental pancreatic intraductal papillary-mucinous neoplasm primary biliary cholangitis subependymal giant cell astrocytoma anemia ductal breast carcinoma in situ inherited neurodegenerative disorder malignant ependymoma medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia retinitis pigmentosa ulcerative colitis astrocytic tumor extrahepatic cholestasis Liver Cirrhosis, Experimental pancreatic intraductal papillary-mucinous neoplasm primary biliary cholangitis subependymal giant cell astrocytoma anemia ductal breast carcinoma in situ inherited neurodegenerative disorder malignant ependymoma medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia retinitis pigmentosa ulcerative colitis astrocytic tumor extrahepatic cholestasis invasive ductal breast carcinoma malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer retinitis pigmentosa 36 atypical teratoid rhabdoid tumor glioblastoma malignant pancreatic neoplasm osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.