1RM6

Structure of 4-hydroxybenzoyl-CoA reductase from Thauera aromatica

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1rm6a1	Alpha and beta proteins (a+b)	alpha/beta-Hammerhead	CO dehydrogenase molybdoprotein N-domain-like	CO dehydrogenase molybdoprotein N-domain-like	4-hydroxybenzoyl-CoA reductase alpha subunit HrcA, N-terminal domain	(Thauera aromatica ) [TaxId: 59405 ],	SCOPe (2.08)
A	d1rm6a2	Alpha and beta proteins (a+b)	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	4-hydroxybenzoyl-CoA reductase alpha subunit HrcA, C-terminal domain	(Thauera aromatica ) [TaxId: 59405 ],	SCOPe (2.08)
D	d1rm6d1	Alpha and beta proteins (a+b)	alpha/beta-Hammerhead	CO dehydrogenase molybdoprotein N-domain-like	CO dehydrogenase molybdoprotein N-domain-like	4-hydroxybenzoyl-CoA reductase alpha subunit HrcA, N-terminal domain	(Thauera aromatica ) [TaxId: 59405 ],	SCOPe (2.08)
D	d1rm6d2	Alpha and beta proteins (a+b)	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	4-hydroxybenzoyl-CoA reductase alpha subunit HrcA, C-terminal domain	(Thauera aromatica ) [TaxId: 59405 ],	SCOPe (2.08)
E	d1rm6e1	Alpha and beta proteins (a+b)	CO dehydrogenase flavoprotein C-domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	4-hydroxybenzoyl-CoA reductase beta subunit HrcB, C-terminal domain	(Thauera aromatica ) [TaxId: 59405 ],	SCOPe (2.08)
E	d1rm6e2	Alpha and beta proteins (a+b)	FAD-binding/transporter-associated domain-like	FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein N-terminal domain-like	4-hydroxybenzoyl-CoA reductase beta subunit HrcB, N-terminal domain	(Thauera aromatica ) [TaxId: 59405 ],	SCOPe (2.08)
B	d1rm6b1	Alpha and beta proteins (a+b)	CO dehydrogenase flavoprotein C-domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	4-hydroxybenzoyl-CoA reductase beta subunit HrcB, C-terminal domain	(Thauera aromatica ) [TaxId: 59405 ],	SCOPe (2.08)
B	d1rm6b2	Alpha and beta proteins (a+b)	FAD-binding/transporter-associated domain-like	FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein N-terminal domain-like	4-hydroxybenzoyl-CoA reductase beta subunit HrcB, N-terminal domain	(Thauera aromatica ) [TaxId: 59405 ],	SCOPe (2.08)
C	d1rm6c1	All alpha proteins	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	4-hydroxybenzoyl-CoA reductase gamma subunit HrcC, C-terminal domain	(Thauera aromatica ) [TaxId: 59405 ],	SCOPe (2.08)
C	d1rm6c2	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	2Fe-2S ferredoxin domains from multidomain proteins	4-hydroxybenzoyl-CoA reductase gamma subunit HrcC, N-terminal domain	(Thauera aromatica ) [TaxId: 59405 ],	SCOPe (2.08)
F	d1rm6f1	All alpha proteins	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	4-hydroxybenzoyl-CoA reductase gamma subunit HrcC, C-terminal domain	(Thauera aromatica ) [TaxId: 59405 ],	SCOPe (2.08)
F	d1rm6f2	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	2Fe-2S ferredoxin domains from multidomain proteins	4-hydroxybenzoyl-CoA reductase gamma subunit HrcC, N-terminal domain	(Thauera aromatica ) [TaxId: 59405 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	CO dehydrogenase molybdoprotein N-domain-like	8029900	4001129	SCOP2 (2022-06-29)
A	SCOP2 Family	Molybdenum cofactor-binding domain	8029902	4001972	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	CO dehydrogenase molybdoprotein N-domain-like	8042279	3000847	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Molybdenum cofactor-binding domain	8042281	3000625	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	CO dehydrogenase molybdoprotein N-domain-like	8042279	3000847	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Molybdenum cofactor-binding domain	8042281	3000625	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	FAD-binding/transporter-associated domain-like	8042284	3000913	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	CO dehydrogenase flavoprotein C-terminal domain-like	8042283	3001921	SCOP2B (2022-06-29)
B	SCOP2 Family	CO dehydrogenase flavoprotein C-terminal domain-like	8029904	4001591	SCOP2 (2022-06-29)
B	SCOP2 Family	CO dehydrogenase flavoprotein N-terminal domain-like	8029905	4002187	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	CO dehydrogenase flavoprotein C-terminal domain-like	8042283	3001921	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	FAD-binding/transporter-associated domain-like	8042284	3000913	SCOP2 (2022-06-29)
C	SCOP2 Family	CO dehydrogenase ISP C-domain like	8029906	4001010	SCOP2 (2022-06-29)
C	SCOP2 Family	2Fe-2S ferredoxin domains from multidomain proteins	8029908	4000241	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	CO dehydrogenase ISP C-domain like	8042285	3000439	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	2Fe-2S ferredoxin-like	8042287	3000113	SCOP2 (2022-06-29)
F	SCOP2B Superfamily	CO dehydrogenase ISP C-domain like	8042285	3000439	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	2Fe-2S ferredoxin-like	8042287	3000113	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ald_Xan_dh_C2	e1rm6A3	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
A	Ald_Xan_dh_C	e1rm6A2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)
D	Ald_Xan_dh_C2	e1rm6D1	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
D	Ald_Xan_dh_C	e1rm6D2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)
E	CO_deh_flav_C	e1rm6E1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
E	FAD_binding_5	e1rm6E2	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
B	CO_deh_flav_C	e1rm6B1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
B	FAD_binding_5	e1rm6B3	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
B	4HBCR_Fe_S_bind	e1rm6B4	A: few secondary structure elements	X: Fe-S cluster binding domain in some xanthine oxidase family enzymes (From Topology)	H: Fe-S cluster binding domain in some xanthine oxidase family enzymes (From Topology)	T: Fe-S cluster binding domain in some xanthine oxidase family enzymes	F: 4HBCR_Fe_S_bind	ECOD (1.6)
C	Fer2_2	e1rm6C1	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
C	Fer2_3	e1rm6C2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2_3	ECOD (1.6)
F	Fer2_2	e1rm6F1	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
F	Fer2_3	e1rm6F2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (4.3.0)
A	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (4.3.0)
D	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (4.3.0)
D	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (4.3.0)
E	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
B	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
C	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
C	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
F	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
F	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF01315	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain (Ald_Xan_dh_C)	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	Domain
A, D	PF20256	Molybdopterin cofactor-binding domain (MoCoBD_2)	Molybdopterin cofactor-binding domain	-	Domain
A, D	PF02738	Molybdopterin cofactor-binding domain (MoCoBD_1)	Molybdopterin cofactor-binding domain	-	Domain
B, E	PF00941	FAD binding domain in molybdopterin dehydrogenase (FAD_binding_5)	FAD binding domain in molybdopterin dehydrogenase	-	Family
B, E	PF03450	CO dehydrogenase flavoprotein C-terminal domain (CO_deh_flav_C)	CO dehydrogenase flavoprotein C-terminal domain	-	Domain
C, F	PF01799	[2Fe-2S] binding domain (Fer2_2)	[2Fe-2S] binding domain	-	Domain
C, F	PF00111	2Fe-2S iron-sulfur cluster binding domain (Fer2)	2Fe-2S iron-sulfur cluster binding domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	4-hydroxybenzoyl-CoA reductase alpha subunit	oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor oxidoreductase activity 4-hydroxybenzoyl-CoA reductase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity cation binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding	-	-
B, E	4-hydroxybenzoyl-CoA reductase beta subunit	oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor oxidoreductase activity 4-hydroxybenzoyl-CoA reductase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor oxidoreductase activity 4-hydroxybenzoyl-CoA reductase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding cation binding metal ion binding	-	-
C, F	4-hydroxybenzoyl-CoA reductase gamma subunit	oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor oxidoreductase activity 4-hydroxybenzoyl-CoA reductase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR046867	Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain	Domain
A, D	IPR017607	4-hydroxybenzoyl-CoA reductase, alpha subunit	Family
A, D	IPR000674	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead	Domain
A, D	IPR016208	Aldehyde oxidase/xanthine dehydrogenase-like	Family
A, D	IPR036856	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily	Homologous Superfamily
A, D	IPR037165	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily	Homologous Superfamily
A, D	IPR008274	Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain	Domain
B, E	IPR016167	FAD-binding, type PCMH, subdomain 1	Homologous Superfamily
B, E	IPR036683	CO dehydrogenase flavoprotein, C-terminal domain superfamily	Homologous Superfamily
B, E	IPR051312	Diverse Substrate Oxidoreductases	Family
B, E	IPR017608	4-hydroxybenzoyl-CoA reductase, beta subunit	Family
B, E	IPR016166	FAD-binding domain, PCMH-type	Domain
B, E	IPR002346	Molybdopterin dehydrogenase, FAD-binding	Domain
B, E	IPR036318	FAD-binding, type PCMH-like superfamily	Homologous Superfamily
B, E	IPR016169	FAD-binding, type PCMH, subdomain 2	Homologous Superfamily
B, E	IPR005107	CO dehydrogenase flavoprotein, C-terminal	Domain
C, F	IPR002888	[2Fe-2S]-binding	Domain
C, F	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
C, F	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
C, F	IPR017606	4-hydroxybenzoyl-CoA reductase, gamma subunit	Family
C, F	IPR036884	[2Fe-2S]-binding domain superfamily	Homologous Superfamily
C, F	IPR051452	Diverse Oxidoreductases	Family
C, F	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
C, F	IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site	Binding Site