Annotations: 1PL8

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1pl8a1	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	Ketose reductase (sorbitol dehydrogenase)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1pl8a2	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	Ketose reductase (sorbitol dehydrogenase)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1pl8c1	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	Ketose reductase (sorbitol dehydrogenase)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1pl8c2	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	Ketose reductase (sorbitol dehydrogenase)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1pl8b1	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	Ketose reductase (sorbitol dehydrogenase)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1pl8b2	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	Ketose reductase (sorbitol dehydrogenase)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1pl8d1	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	Ketose reductase (sorbitol dehydrogenase)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1pl8d2	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	Ketose reductase (sorbitol dehydrogenase)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Alcohol dehydrogenase-like	8057647	4000010	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Zinc-containing alcohol dehydrogenase-like	8057649	3000040	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GroES-like	8057648	3000002	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8057649	3000040	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GroES-like	8057648	3000002	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8057649	3000040	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GroES-like	8057648	3000002	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GroES-like	8057648	3000002	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8057649	3000040	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ADH_N	e1pl8A1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N	ECOD (1.6)
A	ADH_zinc_N	e1pl8A2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
C	ADH_N	e1pl8C1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N	ECOD (1.6)
C	ADH_zinc_N	e1pl8C2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
B	ADH_N	e1pl8B1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N	ECOD (1.6)
B	ADH_zinc_N	e1pl8B2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
D	ADH_N	e1pl8D1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N	ECOD (1.6)
D	ADH_zinc_N	e1pl8D2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
C	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
C	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
B	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
D	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
D	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00107	Zinc-binding dehydrogenase (ADH_zinc_N)	Zinc-binding dehydrogenase	-	Domain
A, B, C, D	PF08240	Alcohol dehydrogenase GroES-like domain (ADH_N)	Alcohol dehydrogenase GroES-like domain	This is the catalytic domain of alcohol dehydrogenases. Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure [1-2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	human sorbitol dehydrogenase	ribitol 2-dehydrogenase (NAD+) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity D-xylulose reductase activity hexitol dehydrogenase activity binding carbohydrate binding (R,R)-butanediol dehydrogenase activity alcohol dehydrogenase [NAD(P)+] activity L-iditol 2-dehydrogenase (NAD+) activity alcohol dehydrogenase (NAD+) activity NAD binding ribitol 2-dehydrogenase (NAD+) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity D-xylulose reductase activity hexitol dehydrogenase activity binding carbohydrate binding (R,R)-butanediol dehydrogenase activity alcohol dehydrogenase [NAD(P)+] activity L-iditol 2-dehydrogenase (NAD+) activity alcohol dehydrogenase (NAD+) activity NAD binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding small molecule binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding D-sorbitol dehydrogenase (acceptor) activity identical protein binding protein binding	D-glucuronate catabolic process to D-xylulose 5-phosphate catabolic process oxoacid metabolic process carbohydrate derivative metabolic process organic acid metabolic process organic acid catabolic process cellular catabolic process monocarboxylic acid catabolic process D-glucuronate catabolic process carboxylic acid catabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process D-glucuronate metabolic process D-glucuronate catabolic process to D-xylulose 5-phosphate catabolic process oxoacid metabolic process carbohydrate derivative metabolic process organic acid metabolic process organic acid catabolic process cellular catabolic process monocarboxylic acid catabolic process D-glucuronate catabolic process carboxylic acid catabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process D-glucuronate metabolic process carbohydrate derivative biosynthetic process uronic acid metabolic process carboxylic acid metabolic process xylulose 5-phosphate metabolic process biosynthetic process organophosphate metabolic process glucuronate metabolic process organophosphate biosynthetic process metabolic process cellular process monocarboxylic acid metabolic process small molecule catabolic process xylulose 5-phosphate biosynthetic process glucuronate catabolic process monosaccharide metabolic process carbohydrate metabolic process fructose biosynthetic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process primary metabolic process monosaccharide biosynthetic process hexose biosynthetic process fructose metabolic process polyol metabolic process xylitol metabolic process organic hydroxy compound metabolic process alcohol metabolic process alditol metabolic process pentitol metabolic process sperm motility reproductive process cilium movement involved in cell motility cilium or flagellum-dependent cell motility cilium-dependent cell motility flagellated sperm motility microtubule-based movement microtubule-based process cilium movement cell motility glucose metabolic process alcohol catabolic process xylitol catabolic process polyol catabolic process carbohydrate catabolic process pentitol catabolic process alditol catabolic process organic hydroxy compound catabolic process hexitol metabolic process hexitol catabolic process sorbitol catabolic process sorbitol metabolic process	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion intracellular membrane-bounded organelle intracellular organelle organelle envelope mitochondrial envelope cytoplasm organelle membrane cytosol cell projection cilium motile cilium plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR013154	Alcohol dehydrogenase-like, N-terminal	Domain
A, B, C, D	IPR020843	Polyketide synthase, enoylreductase domain	Domain
A, B, C, D	IPR002328	Alcohol dehydrogenase, zinc-type, conserved site	Conserved Site
A, B, C, D	IPR011032	GroES-like superfamily	Homologous Superfamily
A, B, C, D	IPR045306	Sorbitol dehydrogenase-like	Family
A, B, C, D	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR013149	Alcohol dehydrogenase-like, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q00796	perinatal necrotizing enterocolitis Myocardial Reperfusion Injury atopic eczema drug-induced liver injury nasopharyngeal carcinoma atypical teratoid rhabdoid tumor glioblastoma interstitial cystitis necrotizing enterocolitis peripheral neuropathy pancreatic intraductal papillary-mucinous neoplasm psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.