1OMI

Crystal structure of PrfA,the transcriptional regulator in Listeria monocytogenes

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1omia2	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	CAP C-terminal domain-like	Listeriolysin regulatory protein PrfA, C-terminal domain	(Listeria monocytogenes ) [TaxId: 1639 ],	SCOPe (2.08)
A	d1omia1	All beta proteins	Double-stranded beta-helix	cAMP-binding domain-like	Listeriolysin regulatory protein PrfA, N-terminal domain	Listeriolysin regulatory protein PrfA, N-terminal domain	(Listeria monocytogenes ) [TaxId: 1639 ],	SCOPe (2.08)
A	d1omia3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Listeria monocytogenes ) [TaxId: 1639 ],	SCOPe (2.08)
B	d1omib2	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	CAP C-terminal domain-like	Listeriolysin regulatory protein PrfA, C-terminal domain	(Listeria monocytogenes ) [TaxId: 1639 ],	SCOPe (2.08)
B	d1omib1	All beta proteins	Double-stranded beta-helix	cAMP-binding domain-like	Listeriolysin regulatory protein PrfA, N-terminal domain	Listeriolysin regulatory protein PrfA, N-terminal domain	(Listeria monocytogenes ) [TaxId: 1639 ],	SCOPe (2.08)
B	d1omib3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Listeria monocytogenes ) [TaxId: 1639 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	cAMP-binding domain-like	8017652	3000084	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Winged helix DNA-binding domain	8017649	3000034	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	cAMP-binding domain-like	8017652	3000084	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Winged helix DNA-binding domain	8017649	3000034	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	cNMP_binding	e1omiA1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding	ECOD (1.6)
A	HTH_Crp_2	e1omiA2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: HTH_Crp_2	ECOD (1.6)
B	cNMP_binding	e1omiB1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: cNMP_binding	ECOD (1.6)
B	HTH_Crp_2	e1omiB2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: HTH_Crp_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
A	1.20.5.460	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Single helix bin	CATH (4.3.0)
A	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
B	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
B	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Listeriolysin regulatory protein	DNA binding binding organic cyclic compound binding nucleic acid binding transcription regulator activity DNA-binding transcription factor activity	-	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR018335	Transcription regulator HTH, Crp-type, conserved site	Conserved Site
A, B	IPR018490	Cyclic nucleotide-binding domain superfamily	Homologous Superfamily
A, B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR012318	Crp-type HTH domain	Domain
A, B	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.