1OLL | pdb_00001oll

Extracellular region of the human receptor NKp46

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1olla1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	I set domains	Ligand binding domain of NK receptor NKp46	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	I set domains	8054838	4007543	SCOP2 (2022-06-29)
A	SCOP2 Family	I set domains	8055616	4007543	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8054839	3000071	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8055615	3000071	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ig_2	e1ollA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Ig_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	NK RECEPTOR	-	response to stimulus defense response response to stress cellular defense response regulation of immune effector process lymphocyte mediated immunity regulation of defense response regulation of natural killer cell mediated cytotoxicity regulation of response to biotic stimulus regulation of cellular process biological process involved in interspecies interaction between organisms regulation of response to external stimulus response to biotic stimulus regulation of response to stress response to stimulus defense response response to stress cellular defense response regulation of immune effector process lymphocyte mediated immunity regulation of defense response regulation of natural killer cell mediated cytotoxicity regulation of response to biotic stimulus regulation of cellular process biological process involved in interspecies interaction between organisms regulation of response to external stimulus response to biotic stimulus regulation of response to stress innate immune response leukocyte mediated immunity regulation of immune system process response to external biotic stimulus natural killer cell mediated immunity regulation of biological process regulation of natural killer cell mediated immunity immune response response to other organism regulation of innate immune response regulation of leukocyte mediated cytotoxicity biological regulation defense response to symbiont response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity regulation of response to stimulus immune system process defense response to other organism natural killer cell mediated cytotoxicity regulation of immune response regulation of cell killing cellular process cell killing multicellular organismal process cell activation natural killer cell activation lymphocyte activation leukocyte activation cellular response to stimulus signaling cell communication immune response-regulating signaling pathway signal transduction	membrane-bounded organelle SWI/SNF complex ATPase complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membraneless organelle chromatin chromosome intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure membrane-bounded organelle SWI/SNF complex ATPase complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membraneless organelle chromatin chromosome intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle membraneless organelle SWI/SNF superfamily-type complex cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR003599	Immunoglobulin domain subtype	Domain
A	IPR050412	Immunoglobulin-like Receptors in Immune Regulation	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O76036	colorectal cancer ovarian cancer inflammatory bowel disease ulcerative colitis osteosarcoma vascular disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.