1NR4

High resolution crystal structures of thymus and activation-regulated chemokine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1nr4b_	Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines	Thymus and activation-regulated chemokine, TRAC	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1nr4c_	Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines	Thymus and activation-regulated chemokine, TRAC	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1nr4e_	Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines	Thymus and activation-regulated chemokine, TRAC	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d1nr4f_	Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines	Thymus and activation-regulated chemokine, TRAC	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d1nr4h_	Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines	Thymus and activation-regulated chemokine, TRAC	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1nr4a_	Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines	Thymus and activation-regulated chemokine, TRAC	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1nr4d_	Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines	Thymus and activation-regulated chemokine, TRAC	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d1nr4g_	Alpha and beta proteins (a+b)	IL8-like	Interleukin 8-like chemokines	Interleukin 8-like chemokines	Thymus and activation-regulated chemokine, TRAC	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Interleukin 8-like chemokines	8036926	3001955	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Interleukin 8-like chemokines	8036926	3001955	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Interleukin 8-like chemokines	8036926	3001955	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Interleukin 8-like chemokines	8036926	3001955	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Interleukin 8-like chemokines	8036926	3001955	SCOP2B (2022-06-29)
A	SCOP2 Family	Interleukin 8-like chemokines	8024547	4000912	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Interleukin 8-like chemokines	8036926	3001955	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Interleukin 8-like chemokines	8036926	3001955	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Interleukin 8-like chemokines	8036926	3001955	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	IL8	e1nr4B1	A: beta barrels	X: IL8-related (From Homology)	H: IL8-related	T: IL8	F: IL8	ECOD (1.6)
C	IL8	e1nr4C1	A: beta barrels	X: IL8-related (From Homology)	H: IL8-related	T: IL8	F: IL8	ECOD (1.6)
E	IL8	e1nr4E1	A: beta barrels	X: IL8-related (From Homology)	H: IL8-related	T: IL8	F: IL8	ECOD (1.6)
F	IL8	e1nr4F1	A: beta barrels	X: IL8-related (From Homology)	H: IL8-related	T: IL8	F: IL8	ECOD (1.6)
H	IL8	e1nr4H1	A: beta barrels	X: IL8-related (From Homology)	H: IL8-related	T: IL8	F: IL8	ECOD (1.6)
A	IL8	e1nr4A1	A: beta barrels	X: IL8-related (From Homology)	H: IL8-related	T: IL8	F: IL8	ECOD (1.6)
D	IL8	e1nr4D1	A: beta barrels	X: IL8-related (From Homology)	H: IL8-related	T: IL8	F: IL8	ECOD (1.6)
G	IL8	e1nr4G1	A: beta barrels	X: IL8-related (From Homology)	H: IL8-related	T: IL8	F: IL8	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
C	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
E	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
F	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
H	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
A	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
D	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
G	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00048	Small cytokines (intecrine/chemokine), interleukin-8 like (IL8)	Small cytokines (intecrine/chemokine), interleukin-8 like	Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Thymus and activation-regulated chemokine	protein binding binding signaling receptor binding molecular function activator activity G protein-coupled receptor binding signaling receptor activator activity cytokine receptor binding chemokine activity molecular function regulator activity cytokine activity signaling receptor regulator activity chemokine receptor binding receptor ligand activity CCR chemokine receptor binding	chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion cell chemotaxis cellular response to stimulus cellular response to chemical stimulus cell migration cellular process cell motility humoral immune response biological process involved in interspecies interaction between organisms chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion cell chemotaxis cellular response to stimulus cellular response to chemical stimulus cell migration cellular process cell motility humoral immune response biological process involved in interspecies interaction between organisms response to other organism defense response immune response defense response to symbiont antimicrobial humoral response response to biotic stimulus antimicrobial humoral immune response mediated by antimicrobial peptide defense response to other organism response to stress immune system process response to external biotic stimulus positive regulation of locomotion regulation of biological process regulation of cell motility regulation of cellular process biological regulation positive regulation of biological process positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration positive regulation of cellular process inflammatory response cell surface receptor signaling pathway signaling response to cytokine response to chemokine cytokine-mediated signaling pathway cellular response to chemokine chemokine-mediated signaling pathway cell communication response to peptide G protein-coupled receptor signaling pathway cellular response to cytokine stimulus signal transduction cell-cell signaling	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001811	Chemokine interleukin-8-like domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036048	Chemokine interleukin-8-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000827	CC chemokine, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR039809	Chemokine beta/gamma/delta	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: Q92583	allergic disease pneumonia dermatitis Experimental Lung Inflammation systemic lupus erythematosus asthma dermatitis, atopic pneumonitis atopic eczema psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.