1NCP

STRUCTURAL CHARACTERIZATION OF A 39 RESIDUE SYNTHETIC PEPTIDE CONTAINING THE TWO ZINC BINDING DOMAINS FROM THE HIV-1 P7 NUCLEOCAPSID PROTEIN BY CD AND NMR SPECTROSCOPY

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth N]	d1ncpn_	Small proteins	Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	HIV nucleocapsid	(Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)
B [auth C]	d1ncpc_	Small proteins	Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	HIV nucleocapsid	(Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth N]	PF00098	Zinc knuckle (zf-CCHC)	Zinc knuckle	The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eu ...	The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eukaryotic gene regulation, such as C. elegans GLH-1. Structure is an 18-residue zinc finger.	Domain
B [auth C]	PF00098	Zinc knuckle (zf-CCHC)	Zinc knuckle	The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eu ...	The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eukaryotic gene regulation, such as C. elegans GLH-1. Structure is an 18-residue zinc finger.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth N]	HIV-1 P7 NUCLEOCAPSID PROTEIN	catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid RNA exonuclease activity RNA nuclease activity hydrolase activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds exoribonuclease H activity exonuclease activity catalytic activity catalytic activity, acting on DNA DNA-directed DNA polymerase activity catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid RNA exonuclease activity RNA nuclease activity hydrolase activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds exoribonuclease H activity exonuclease activity catalytic activity catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity transferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups DNA binding binding nucleic acid binding RNA binding RNA stem-loop binding identical protein binding protein binding peptidase activity catalytic activity, acting on a protein integrase activity aspartic-type peptidase activity aspartic-type endopeptidase activity endopeptidase activity lipid binding telomerase activity RNA-directed DNA polymerase activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters RNA-DNA hybrid ribonuclease activity RNA endonuclease activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters structural molecule activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host gene expression biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated perturbation of host gene expression modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction viral process viral life cycle symbiont entry into host cell symbiont entry into host viral genome integration into host DNA viral penetration into host nucleus symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host gene expression biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated perturbation of host gene expression modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction viral process viral life cycle symbiont entry into host cell symbiont entry into host viral genome integration into host DNA viral penetration into host nucleus intracellular transport of virus transport of virus establishment of integrated proviral latency viral latency establishment of viral latency viral gene expression viral translational frameshifting viral translation primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process nucleobase-containing compound metabolic process DNA recombination DNA metabolic process nucleic acid metabolic process regulation of biological process symbiont-mediated activation of host programmed cell death regulation of cellular process symbiont-mediated activation of host apoptosis symbiont-mediated perturbation of host programmed cell death biological regulation regulation of killing of cells of another organism disruption of cell in another organism regulation of cell killing symbiont-mediated perturbation of host apoptosis disruption of anatomical structure in another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing	cellular anatomical structure membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host multivesicular body host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell part host cell late endosome host cell endosome host intracellular region viral nucleocapsid cellular anatomical structure membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host multivesicular body host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell part host cell late endosome host cell endosome host intracellular region viral nucleocapsid viral capsid virion component host cell plasma membrane host cell membrane host cell virion membrane host cell nucleus
B [auth C]	HIV-1 P7 NUCLEOCAPSID PROTEIN	catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid RNA exonuclease activity RNA nuclease activity hydrolase activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds exoribonuclease H activity exonuclease activity catalytic activity catalytic activity, acting on DNA DNA-directed DNA polymerase activity catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid RNA exonuclease activity RNA nuclease activity hydrolase activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds exoribonuclease H activity exonuclease activity catalytic activity catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity transferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups DNA binding binding nucleic acid binding RNA binding RNA stem-loop binding aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein aspartic-type endopeptidase activity endopeptidase activity lipid binding telomerase activity RNA-directed DNA polymerase activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters RNA-DNA hybrid ribonuclease activity RNA endonuclease activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters structural molecule activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host gene expression biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated perturbation of host gene expression modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell viral process symbiont entry into host viral life cycle viral genome integration into host DNA viral penetration into host nucleus symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host gene expression biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process symbiont-mediated perturbation of host gene expression modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell viral process symbiont entry into host viral life cycle viral genome integration into host DNA viral penetration into host nucleus intracellular transport of virus transport of virus nucleobase-containing compound metabolic process metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process DNA integration nucleic acid metabolic process establishment of integrated proviral latency viral latency establishment of viral latency viral gene expression viral translational frameshifting viral translation DNA recombination regulation of biological process symbiont-mediated activation of host programmed cell death regulation of cellular process symbiont-mediated activation of host apoptosis symbiont-mediated perturbation of host programmed cell death biological regulation regulation of killing of cells of another organism disruption of cell in another organism regulation of cell killing symbiont-mediated perturbation of host apoptosis disruption of anatomical structure in another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing proteolysis protein metabolic process	cellular anatomical structure membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host multivesicular body host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell part host cell late endosome host cell endosome host intracellular region viral nucleocapsid cellular anatomical structure membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host multivesicular body host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell part host cell late endosome host cell endosome host intracellular region viral nucleocapsid viral capsid virion component host cell plasma membrane host cell membrane host cell virion membrane host cell nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth N]	IPR036397	Ribonuclease H superfamily	Homologous Superfamily
A [auth N]	IPR043128	Reverse transcriptase/Diguanylate cyclase domain	Homologous Superfamily
A [auth N]	IPR001995	Peptidase A2A, retrovirus, catalytic	Domain
A [auth N]	IPR001878	Zinc finger, CCHC-type	Domain
A [auth N]	IPR008919	Retrovirus capsid, N-terminal	Homologous Superfamily
A [auth N]	IPR012344	Matrix protein, lentiviral and alpha-retroviral, N-terminal	Homologous Superfamily
A [auth N]	IPR036862	Integrase, C-terminal domain superfamily, retroviral	Homologous Superfamily
A [auth N]	IPR018061	Retropepsins	Domain
A [auth N]	IPR010661	Reverse transcriptase thumb	Domain
A [auth N]	IPR002156	Ribonuclease H domain	Domain
A [auth N]	IPR036875	Zinc finger, CCHC-type superfamily	Homologous Superfamily
A [auth N]	IPR003308	Integrase, N-terminal zinc-binding domain	Domain
A [auth N]	IPR001584	Integrase, catalytic core	Domain
A [auth N]	IPR045345	Retroviral nucleocapsid Gag protein p24, C-terminal domain	Domain
A [auth N]	IPR010999	Retroviral matrix protein	Homologous Superfamily
A [auth N]	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily
A [auth N]	IPR001969	Aspartic peptidase, active site	Active Site
A [auth N]	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily
A [auth N]	IPR017856	Integrase-like, N-terminal	Homologous Superfamily
A [auth N]	IPR000071	Immunodeficiency lentiviral matrix, N-terminal	Domain
A [auth N]	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
A [auth N]	IPR001037	Integrase, C-terminal, retroviral	Domain
A [auth N]	IPR034170	Retropepsin-like catalytic domain	Domain
A [auth N]	IPR000477	Reverse transcriptase domain	Domain
A [auth N]	IPR010659	Reverse transcriptase connection	Domain
A [auth N]	IPR008916	Retrovirus capsid, C-terminal	Homologous Superfamily
B [auth C]	IPR036397	Ribonuclease H superfamily	Homologous Superfamily
B [auth C]	IPR043128	Reverse transcriptase/Diguanylate cyclase domain	Homologous Superfamily
B [auth C]	IPR001995	Peptidase A2A, retrovirus, catalytic	Domain
B [auth C]	IPR001878	Zinc finger, CCHC-type	Domain
B [auth C]	IPR008919	Retrovirus capsid, N-terminal	Homologous Superfamily
B [auth C]	IPR012344	Matrix protein, lentiviral and alpha-retroviral, N-terminal	Homologous Superfamily
B [auth C]	IPR036862	Integrase, C-terminal domain superfamily, retroviral	Homologous Superfamily
B [auth C]	IPR018061	Retropepsins	Domain
B [auth C]	IPR010661	Reverse transcriptase thumb	Domain
B [auth C]	IPR002156	Ribonuclease H domain	Domain
B [auth C]	IPR036875	Zinc finger, CCHC-type superfamily	Homologous Superfamily
B [auth C]	IPR003308	Integrase, N-terminal zinc-binding domain	Domain
B [auth C]	IPR001584	Integrase, catalytic core	Domain
B [auth C]	IPR045345	Retroviral nucleocapsid Gag protein p24, C-terminal domain	Domain
B [auth C]	IPR010999	Retroviral matrix protein	Homologous Superfamily
B [auth C]	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily
B [auth C]	IPR001969	Aspartic peptidase, active site	Active Site
B [auth C]	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily
B [auth C]	IPR017856	Integrase-like, N-terminal	Homologous Superfamily
B [auth C]	IPR000071	Immunodeficiency lentiviral matrix, N-terminal	Domain
B [auth C]	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
B [auth C]	IPR001037	Integrase, C-terminal, retroviral	Domain
B [auth C]	IPR034170	Retropepsin-like catalytic domain	Domain
B [auth C]	IPR000477	Reverse transcriptase domain	Domain
B [auth C]	IPR010659	Reverse transcriptase connection	Domain
B [auth C]	IPR008916	Retrovirus capsid, C-terminal	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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1NCP

STRUCTURAL CHARACTERIZATION OF A 39 RESIDUE SYNTHETIC PEPTIDE CONTAINING THE TWO ZINC BINDING DOMAINS FROM THE HIV-1 P7 NUCLEOCAPSID PROTEIN BY CD AND NMR SPECTROSCOPY

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage