1MV4 | pdb_00001mv4

TM9A251-284: A Peptide Model of the C-Terminus of a Rat Striated Alpha Tropomyosin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1mv4a1	Coiled coil proteins	Parallel coiled-coil	Tropomyosin	Tropomyosin	Tropomyosin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d1mv4a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1mv4b1	Coiled coil proteins	Parallel coiled-coil	Tropomyosin	Tropomyosin	Tropomyosin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1mv4b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Tropomyosin 1 alpha chain	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding protein heterodimerization activity protein dimerization activity identical protein binding protein homodimerization activity disordered domain specific binding protein domain specific binding	regulation of vascular associated smooth muscle cell migration negative regulation of locomotion regulation of biological process vascular associated smooth muscle cell migration regulation of cell motility regulation of cellular process negative regulation of vascular associated smooth muscle cell migration regulation of smooth muscle cell migration biological regulation negative regulation of biological process smooth muscle cell migration muscle cell migration negative regulation of smooth muscle cell migration regulation of locomotion regulation of cell migration regulation of vascular associated smooth muscle cell migration negative regulation of locomotion regulation of biological process vascular associated smooth muscle cell migration regulation of cell motility regulation of cellular process negative regulation of vascular associated smooth muscle cell migration regulation of smooth muscle cell migration biological regulation negative regulation of biological process smooth muscle cell migration muscle cell migration negative regulation of smooth muscle cell migration regulation of locomotion regulation of cell migration negative regulation of cellular process negative regulation of cell motility cell migration cellular process cell motility locomotion negative regulation of cell migration multicellular organismal process system process muscle filament sliding actin filament-based process actin-mediated cell contraction actin filament-based movement muscle contraction muscle system process actin-myosin filament sliding developmental process multicellular organism development embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development regulation of developmental process regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis regulation of biological quality regulation of anatomical structure morphogenesis cell adhesion positive regulation of cell adhesion regulation of cell adhesion positive regulation of biological process positive regulation of cellular process cellular response to stimulus response to stimulus cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound response to reactive oxygen species cellular response to reactive oxygen species response to oxidative stress cellular response to chemical stimulus cellular response to stress response to stress response to chemical regulation of cellular component size protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization cellular component biogenesis actin filament capping cellular component assembly negative regulation of supramolecular fiber organization negative regulation of actin filament polymerization cellular component disassembly negative regulation of cellular component organization actin filament organization regulation of organelle organization negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of supramolecular fiber organization supramolecular fiber organization regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process cellular component organization regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly protein-containing complex assembly negative regulation of protein polymerization cellular component organization or biogenesis regulation of actin filament polymerization actin polymerization or depolymerization protein polymerization regulation of actin filament organization actin cytoskeleton organization actin filament polymerization protein-containing complex organization regulation of protein depolymerization negative regulation of cytoskeleton organization regulation of actin polymerization or depolymerization regulation of cellular component biogenesis organelle organization negative regulation of organelle organization regulation of actin filament length regulation of actin cytoskeleton organization negative regulation of actin filament depolymerization protein depolymerization cytoskeleton organization regulation of anatomical structure size wound healing response to wounding plasma membrane bounded cell projection organization ruffle organization cell projection organization heart process circulatory system process cardiac muscle contraction heart contraction blood circulation striated muscle contraction ventricular cardiac muscle tissue morphogenesis heart morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development cardiac chamber development animal organ morphogenesis muscle tissue development muscle organ development system development heart development cardiac chamber morphogenesis cardiac muscle tissue development animal organ development tissue development muscle tissue morphogenesis circulatory system development tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis positive regulation of molecular function regulation of molecular function regulation of ATP-dependent activity positive regulation of ATP-dependent activity positive regulation of organelle organization positive regulation of cellular component organization regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly stress fiber assembly actomyosin structure organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization positive regulation of supramolecular fiber organization regulation of stress fiber assembly contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly cellular developmental process cellular component assembly involved in morphogenesis cell development membraneless organelle assembly muscle cell differentiation striated muscle cell development cellular anatomical entity morphogenesis muscle cell development cell differentiation sarcomere organization organelle assembly myofibril assembly anatomical structure formation involved in morphogenesis striated muscle cell differentiation regulation of vascular associated smooth muscle cell proliferation negative regulation of cell population proliferation cell population proliferation regulation of smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation regulation of systemic arterial blood pressure mediated by a chemical signal regulation of heart contraction regulation of system process positive regulation of blood pressure positive regulation of blood circulation regulation of systemic arterial blood pressure by norepinephrine-epinephrine positive regulation of blood pressure by epinephrine-norepinephrine regulation of multicellular organismal process regulation of heart rate regulation of heart rate by chemical signal regulation of blood pressure positive regulation of heart rate positive regulation of heart rate by epinephrine-norepinephrine positive regulation of heart contraction regulation of blood circulation regulation of systemic arterial blood pressure positive regulation of heart rate by epinephrine positive regulation of multicellular organismal process	ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection cellular anatomical structure ruffle membrane plasma membrane region cell projection membrane intracellular organelle intracellular anatomical structure ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection cellular anatomical structure ruffle membrane plasma membrane region cell projection membrane intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm protein-containing complex contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex bleb actin filament bundle actomyosin stress fiber contractile actin filament bundle polymeric cytoskeletal fiber actin filament

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000533	Tropomyosin	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.