Annotations: 1MR1

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1mr1a_	All beta proteins	SMAD/FHA domain	SMAD/FHA domain	SMAD domain	Smad4 tumor suppressor C-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1mr1b_	All beta proteins	SMAD/FHA domain	SMAD/FHA domain	SMAD domain	Smad4 tumor suppressor C-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1mr1c1	Alpha and beta proteins (a+b)	SAND domain-like	SAND domain-like	SMAD4-binding domain of oncoprotein Ski	SMAD4-binding domain of oncoprotein Ski	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1mr1c2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1mr1d1	Alpha and beta proteins (a+b)	SAND domain-like	SAND domain-like	SMAD4-binding domain of oncoprotein Ski	SMAD4-binding domain of oncoprotein Ski	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1mr1d2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SMAD/FHA domain-like	8041255	3000137	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SMAD/FHA domain-like	8041255	3000137	SCOP2B (2022-06-29)
C	SCOP2 Family	SMAD4-binding domain of oncoprotein Ski	8031381	4003188	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	SAND domain-like	8043759	3000421	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	SAND domain-like	8043759	3000421	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MH2	e1mr1A1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: MH2	ECOD (1.6)
B	MH2	e1mr1B1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: MH2	ECOD (1.6)
C	c-SKI_SMAD_bind	e1mr1C1	A: beta barrels	X: SH3	H: SAND (From Topology)	T: SAND	F: c-SKI_SMAD_bind	ECOD (1.6)
D	c-SKI_SMAD_bind	e1mr1D1	A: beta barrels	X: SH3	H: SAND (From Topology)	T: SAND	F: c-SKI_SMAD_bind	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.200.10	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)
B	2.60.200.10	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)
C	3.10.390.10	Alpha Beta	Roll	SAND domain	SAND domain-like	CATH (4.3.0)
D	3.10.390.10	Alpha Beta	Roll	SAND domain	SAND domain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03166	MH2 domain (MH2)	MH2 domain	-	Family
C, D	PF08782	c-SKI Smad4 binding domain (c-SKI_SMAD_bind)	c-SKI Smad4 binding domain	c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins [1]. This domain binds to Smad4 [2]	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Mothers against decapentaplegic homolog 4	cytoskeletal protein binding protein binding binding filamin binding sequence-specific DNA binding DNA binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity cation binding ion binding cytoskeletal protein binding protein binding binding filamin binding sequence-specific DNA binding DNA binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity cation binding ion binding metal ion binding small molecule binding transcription factor binding transcription coregulator binding transcription corepressor binding collagen binding protein-containing complex binding identical protein binding protein homodimerization activity protein dimerization activity transcription coactivator binding SMAD binding R-SMAD binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding transcription regulatory region nucleic acid binding sulfate binding anion binding sulfur compound binding I-SMAD binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding	cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling developmental process heart development multicellular organismal process cardiac chamber morphogenesis animal organ development heart morphogenesis ventricular septum development circulatory system development multicellular organism development anatomical structure morphogenesis cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis cardiac chamber development anatomical structure development animal organ morphogenesis cardiac ventricle development system development brainstem development atrioventricular canal development negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process negative regulation of cell communication negative regulation of cellular process negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction negative regulation of ERK1 and ERK2 cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade sexual reproduction reproductive process fertilization single fertilization positive regulation of cell population proliferation positive regulation of cell proliferation involved in heart morphogenesis heart valve development cell proliferation involved in heart valve development cell population proliferation regulation of cell proliferation involved in heart valve morphogenesis cell proliferation involved in heart valve morphogenesis cell proliferation involved in heart morphogenesis positive regulation of cell proliferation involved in heart valve morphogenesis heart valve morphogenesis regulation of cell population proliferation regulation of cell proliferation involved in heart morphogenesis positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process positive regulation of metabolic process regulation of RNA metabolic process miRNA transcription positive regulation of biosynthetic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulation of miRNA transcription outflow tract septum morphogenesis outflow tract morphogenesis skin development gland development sebaceous gland development gonad development reproductive system development sex differentiation female gonad development female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction development of primary sexual characteristics reproductive structure development female gonad morphogenesis gonad morphogenesis negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process cellular developmental process endocardial cushion morphogenesis mesenchyme development endocardial cushion development cell differentiation cardiac epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation mesenchyme morphogenesis tissue development epithelial to mesenchymal transition endocardial cushion formation tissue morphogenesis anatomical structure formation involved in morphogenesis mesenchymal cell differentiation cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway tube development male gonad development male sex differentiation development of primary male sexual characteristics seminiferous tubule development negative regulation of cardiac myofibril assembly negative regulation of muscle cell differentiation regulation of cell differentiation regulation of cardiac muscle cell differentiation muscle cell differentiation regulation of cell development muscle structure development cellular component biogenesis cellular component assembly cellular anatomical entity morphogenesis negative regulation of cardiac muscle cell differentiation actin filament-based process negative regulation of supramolecular fiber organization muscle tissue development cardiac cell development regulation of cardiac myofibril assembly negative regulation of cardiocyte differentiation negative regulation of cellular component organization actomyosin structure organization negative regulation of striated muscle cell differentiation regulation of organelle organization myofibril assembly regulation of muscle cell differentiation regulation of organelle assembly regulation of supramolecular fiber organization regulation of cardiocyte differentiation striated muscle cell differentiation supramolecular fiber organization negative regulation of multicellular organismal process regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process regulation of developmental process cardiac muscle cell development cellular component assembly involved in morphogenesis negative regulation of organelle assembly cell development membraneless organelle assembly regulation of striated muscle cell differentiation striated muscle tissue development cellular component organization striated muscle cell development muscle cell development negative regulation of cell differentiation regulation of multicellular organismal process cellular component organization or biogenesis organelle assembly actin cytoskeleton organization negative regulation of cytoskeleton organization cardiac muscle tissue development negative regulation of developmental process cardiac muscle cell differentiation regulation of cellular component biogenesis cardiocyte differentiation organelle organization negative regulation of organelle organization cardiac myofibril assembly regulation of actomyosin structure organization regulation of actin cytoskeleton organization cytoskeleton organization gastrulation with mouth forming second embryonic morphogenesis embryo development gastrulation formation of anatomical boundary regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition positive regulation of developmental process positive regulation of cell differentiation positive regulation of multicellular organismal process homeostatic process response to oxygen-containing compound cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular homeostasis response to monosaccharide response to carbohydrate chemical homeostasis response to glucose response to chemical glucose homeostasis carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus positive regulation of cellular component organization positive regulation of cellular component biogenesis positive regulation of extracellular matrix organization extracellular matrix organization regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly regulation of extracellular matrix organization extracellular matrix assembly extracellular structure organization external encapsulating structure organization ventricular cardiac muscle tissue morphogenesis left ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue development muscle organ development muscle tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac left ventricle morphogenesis muscle organ morphogenesis activin receptor signaling pathway positive regulation of cardiac muscle cell apoptotic process positive regulation of programmed cell death muscle cell apoptotic process positive regulation of striated muscle cell apoptotic process regulation of apoptotic process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process cardiac muscle cell apoptotic process positive regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process apoptotic process programmed cell death regulation of localization system process regulation of system process localization regulation of luteinizing hormone secretion luteinizing hormone secretion regulation of biological quality regulation of hormone levels establishment of localization positive regulation of luteinizing hormone secretion regulation of secretion endocrine hormone secretion regulation of endocrine process regulation of hormone secretion gonadotropin secretion transport positive regulation of secretion by cell hormone secretion secretion by cell positive regulation of hormone secretion regulation of secretion by cell positive regulation of secretion signal release positive regulation of gonadotropin secretion secretion regulation of transport regulation of gonadotropin secretion cell-cell signaling export from cell endocrine process positive regulation of transport hormone transport metanephric mesenchyme development renal system development kidney mesenchyme development metanephros development metanephric mesenchyme morphogenesis kidney mesenchyme morphogenesis kidney development uterus development interleukin-6-mediated signaling pathway response to interleukin-6 cellular response to interleukin-6 response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to cytokine stimulus follicle-stimulating hormone secretion positive regulation of follicle-stimulating hormone secretion regulation of follicle-stimulating hormone secretion adrenal gland development endocrine system development axonogenesis cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell morphogenesis neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis plasma membrane bounded cell projection organization axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons neuron projection guidance neuron development endoderm development mesendoderm development mesoderm development epithelium development endothelial cell differentiation endothelium development cardiac endothelial cell differentiation endocardium development epithelial cell differentiation endocardial cell differentiation limb development appendage development embryonic limb morphogenesis embryonic appendage morphogenesis appendage morphogenesis embryonic digit morphogenesis limb morphogenesis cellular response to BMP stimulus response to BMP somitogenesis embryonic pattern specification chordate embryonic development somite rostral/caudal axis specification anterior/posterior pattern specification segmentation pattern specification process regionalization embryonic axis specification anterior/posterior axis specification embryo development ending in birth or egg hatching somite development axis specification intracellular iron ion homeostasis inorganic ion homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis spermatogenesis multicellular organismal reproductive process male gamete generation gamete generation neural crest cell differentiation stem cell differentiation positive regulation of gene expression regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of Wnt signaling pathway Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway regulation of growth growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth nephrogenic mesenchyme development nephrogenic mesenchyme morphogenesis nephron development extrinsic apoptotic signaling pathway apoptotic signaling pathway in utero embryonic development ovarian follicle development secondary palate development roof of mouth development response to decreased oxygen levels response to hypoxia response to stress response to oxygen levels response to abiotic stimulus regulation of transforming growth factor beta production regulation of transforming growth factor beta2 production transforming growth factor beta2 production cytokine production regulation of cytokine production transforming growth factor beta production catabolic process macromolecule catabolic process negative regulation of protein catabolic process protein metabolic process negative regulation of protein metabolic process negative regulation of catabolic process regulation of protein metabolic process protein catabolic process regulation of catabolic process regulation of protein catabolic process muscle hypertrophy regulation of muscle adaptation negative regulation of muscle hypertrophy striated muscle hypertrophy regulation of muscle system process muscle system process regulation of muscle hypertrophy regulation of cardiac muscle hypertrophy muscle adaptation cardiac muscle hypertrophy negative regulation of cardiac muscle hypertrophy regulation of multicellular organismal development epidermis development molting cycle process hair cycle regulation of hair cycle skin epidermis development hair follicle development molting cycle regulation of hair follicle development hair cycle process mesonephric epithelium development kidney epithelium development nephron morphogenesis branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development ureteric bud morphogenesis tube morphogenesis branching involved in ureteric bud morphogenesis renal tubule development epithelial tube morphogenesis nephron epithelium development ureteric bud development mesonephros development morphogenesis of an epithelium kidney morphogenesis morphogenesis of a branching structure mesonephric tubule morphogenesis mesonephric tubule development renal tubule morphogenesis morphogenesis of a branching epithelium positive regulation of transcription by RNA polymerase II neuron fate commitment cell fate specification neuron fate specification cell fate commitment ossification osteoblast differentiation BMP signaling pathway epithelium migration tissue migration ameboidal-type cell migration epithelial cell migration cell migration cell motility regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus positive regulation of cellular response to transforming growth factor beta stimulus developmental growth cardiac conduction system development negative regulation of cell population proliferation atrioventricular valve development atrioventricular valve formation heart valve formation atrioventricular valve morphogenesis striated muscle adaptation cardiac muscle adaptation cardiac muscle hypertrophy in response to stress muscle hypertrophy in response to stress endothelial cell activation cell activation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle activin responsive factor complex intracellular organelle organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle activin responsive factor complex intracellular organelle organelle SMAD protein complex membraneless organelle intracellular membraneless organelle chromatin chromosome heteromeric SMAD protein complex centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
C, D	Ski oncogene	DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity deacetylase activity enzyme regulator activity protein lysine deacetylase activity catalytic activity, acting on a protein deacylase activity enzyme inhibitor activity histone deacetylase activity molecular function inhibitor activity histone deacetylase inhibitor activity molecular function regulator activity histone deacetylase regulator activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity deacetylase activity enzyme regulator activity protein lysine deacetylase activity catalytic activity, acting on a protein deacylase activity enzyme inhibitor activity histone deacetylase activity molecular function inhibitor activity histone deacetylase inhibitor activity molecular function regulator activity histone deacetylase regulator activity catalytic activity ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding identical protein binding protein domain specific binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding kinase binding protein kinase binding SMAD binding transcription factor binding DNA-binding transcription factor binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding cellular response to stimulus activin receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process response to stimulus signaling negative regulation of signaling regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding cellular response to stimulus activin receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process response to stimulus signaling negative regulation of signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of activin receptor signaling pathway negative regulation of cellular process signal transduction enzyme-linked receptor protein signaling pathway regulation of biological process regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus regulation of cell communication cellular process transforming growth factor beta receptor superfamily signaling pathway regulation of activin receptor signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway developmental process multicellular organismal process heart development heart growth cell population proliferation developmental growth cardiac muscle tissue development cardiac muscle cell proliferation growth animal organ development organ growth tissue development striated muscle tissue development circulatory system development multicellular organism development anatomical structure development muscle cell proliferation cardiac muscle tissue growth muscle tissue development striated muscle cell proliferation system development cellular developmental process peripheral nervous system axon ensheathment peripheral nervous system development cell development nervous system development glial cell development myelination neurogenesis Schwann cell development gliogenesis axon ensheathment ensheathment of neurons glial cell differentiation cell differentiation myelination in peripheral nervous system Schwann cell differentiation sensory organ development eye development retina development in camera-type eye visual system development camera-type eye development sensory system development cellular response to growth factor stimulus negative regulation of cellular response to growth factor stimulus negative regulation of BMP signaling pathway cellular response to endogenous stimulus BMP signaling pathway cellular response to BMP stimulus regulation of BMP signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus response to BMP response to growth factor muscle structure development striated muscle cell differentiation muscle cell differentiation myotube differentiation negative regulation of intracellular signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette SMAD protein signal transduction regulation of SMAD protein signal transduction negative regulation of SMAD protein signal transduction embryonic epithelial tube formation chordate embryonic development tube formation embryo development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium anatomical structure morphogenesis tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure negative regulation of transforming growth factor beta receptor signaling pathway cellular response to transforming growth factor beta stimulus regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process positive regulation of response to stimulus positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of cellular process regulation of Wnt signaling pathway positive regulation of signaling camera-type eye morphogenesis eye morphogenesis sensory organ morphogenesis animal organ morphogenesis negative regulation of cell population proliferation fibroblast proliferation regulation of fibroblast proliferation regulation of cell population proliferation negative regulation of fibroblast proliferation somatic stem cell population maintenance maintenance of cell number stem cell population maintenance cell motility RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process head development olfactory lobe development forebrain development brain development central nervous system development olfactory bulb development telencephalon development skeletal system development skeletal system morphogenesis bone morphogenesis bone development nose morphogenesis nose development respiratory system development myotube cell development skeletal muscle fiber development skeletal muscle tissue development skeletal muscle organ development striated muscle cell development muscle cell development muscle organ development face morphogenesis head morphogenesis face development body morphogenesis regulation of osteoblast differentiation regulation of developmental process negative regulation of osteoblast differentiation negative regulation of developmental process regulation of cell differentiation osteoblast differentiation ossification negative regulation of cell differentiation limb development appendage development embryonic limb morphogenesis embryonic appendage morphogenesis appendage morphogenesis limb morphogenesis regulation of neurogenesis regulation of gliogenesis negative regulation of glial cell proliferation regulation of cell development negative regulation of Schwann cell proliferation regulation of nervous system development negative regulation of neurogenesis regulation of glial cell proliferation regulation of multicellular organismal process negative regulation of nervous system development Schwann cell proliferation regulation of multicellular organismal development regulation of Schwann cell proliferation negative regulation of gliogenesis negative regulation of cell development glial cell proliferation negative regulation of multicellular organismal process anterior/posterior axis specification anterior/posterior pattern specification pattern specification process axis specification regionalization lens morphogenesis in camera-type eye lens development in camera-type eye roof of mouth development	protein-containing complex transcription regulator complex cellular anatomical structure intracellular anatomical structure cytoplasm intracellular organelle centrosome microtubule organizing center cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton membrane-bounded organelle protein-containing complex transcription regulator complex cellular anatomical structure intracellular anatomical structure cytoplasm intracellular organelle centrosome microtubule organizing center cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen transcription repressor complex nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013019	MAD homology, MH1	Domain
A, B	IPR013790	Dwarfin	Family
A, B	IPR003619	MAD homology 1, Dwarfin-type	Domain
A, B	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
A, B	IPR036578	SMAD MH1 domain superfamily	Homologous Superfamily
A, B	IPR017855	SMAD-like domain superfamily	Homologous Superfamily
A, B	IPR001132	SMAD domain, Dwarfin-type	Domain
C, D	IPR009061	Putative DNA-binding domain superfamily	Homologous Superfamily
C, D	IPR047315	Ski oncogene-like, Dachshund-homology domain	Domain
C, D	IPR010919	SAND-like domain superfamily	Homologous Superfamily
C, D	IPR023216	Transcription regulator SKI/SnoN	Family
C, D	IPR037000	Ski-like, DNA-binding domain superfamily	Homologous Superfamily
C, D	IPR003380	SKI/SNO/DAC domain	Domain
C, D	IPR014890	c-SKI SMAD4-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q13485	hereditary hemorrhagic telangiectasia myopathy cholangiocarcinoma juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome Myhre syndrome esophageal adenocarcinoma familial pancreatic carcinoma colorectal cancer generalized juvenile polyposis/juvenile polyposis coli brachydactyly juvenile polyposis syndrome Craniofacial Abnormalities exocrine pancreatic carcinoma gastric cancer intrahepatic cholangiocarcinoma hereditary hemorrhagic telangiectasia myopathy cholangiocarcinoma juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome Myhre syndrome esophageal adenocarcinoma familial pancreatic carcinoma colorectal cancer generalized juvenile polyposis/juvenile polyposis coli brachydactyly juvenile polyposis syndrome Craniofacial Abnormalities exocrine pancreatic carcinoma gastric cancer intrahepatic cholangiocarcinoma cancer invasive ductal breast carcinoma malignant pancreatic neoplasm muscle tissue disease ovarian cancer allergic rhinitis pulmonary arterial hypertension benign neoplasm of pancreas hereditary diffuse gastric adenocarcinoma subependymal giant cell astrocytoma intellectual disability breast disease digestive system disease muscular disease oligodendroglioma pancreatic neoplasm arthrogryposis thoracic aortic aneurysm large cell medulloblastoma colorectal carcinoma malignant ependymoma medulloblastoma Ehlers-Danlos syndrome osteosarcoma gastric neoplasm atrial fibrillation small intestine neoplasm bile duct cancer idiopathic pulmonary arterial hypertension breast cancer cerebrovascular disorder colorectal adenocarcinoma malignant glioma
C, D	Pharos: P12755	chromosome 1p36 deletion syndrome Shprintzen-Goldberg syndrome craniosynostosis Craniofacial Abnormalities neural tube defect aortic aneurysm iniencephaly juvenile dermatomyositis neurenteric cyst pancreatic intraductal papillary-mucinous carcinoma arthrogryposis Pick disease diastematomyelia tuberculosis heart disease chromosome 1p36 deletion syndrome Shprintzen-Goldberg syndrome craniosynostosis Craniofacial Abnormalities neural tube defect aortic aneurysm iniencephaly juvenile dermatomyositis neurenteric cyst pancreatic intraductal papillary-mucinous carcinoma arthrogryposis Pick disease diastematomyelia tuberculosis heart disease intellectual disability large cell medulloblastoma ovarian cancer acute myeloid leukemia pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor psoriasis craniorachischisis tethered spinal cord syndrome Ehlers-Danlos syndrome gastric carcinoma hydrocephalus invasive ductal breast carcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cancer rheumatoid arthritis thoracic aortic aneurysm Emery-Dreifuss muscular dystrophy head and neck cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.