1MN3 | pdb_00001mn3

Cue domain of yeast Vps9p

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1mn3a_	All alpha proteins	RuvA C-terminal domain-like	UBA-like	CUE domain	Vacuolar protein sorting-associated protein vps9	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	CUE domain	8020426	4003786	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	UBA-like	8032806	3001235	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CUE	e1mn3A1	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: CUE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.8.10	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02845	CUE domain (CUE)	CUE domain	CUE domains have been shown to bind ubiquitin [3-4]. It has been suggested that CUE domains are related to Pfam:PF00627 [4] and this has been confirmed by the structure of the domain [5]. CUE domains also occur in two protein of the IL-1 signal trans ...	CUE domains have been shown to bind ubiquitin [3-4]. It has been suggested that CUE domains are related to Pfam:PF00627 [4] and this has been confirmed by the structure of the domain [5]. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2 [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Vacuolar protein sorting-associated protein VPS9	small GTPase binding protein binding binding enzyme binding GTPase binding enzyme regulator activity guanyl nucleotide binding GTP binding nucleotide binding hydrolase activity guanyl ribonucleotide binding GDP binding purine ribonucleotide binding ion binding small GTPase binding protein binding binding enzyme binding GTPase binding enzyme regulator activity guanyl nucleotide binding GTP binding nucleotide binding hydrolase activity guanyl ribonucleotide binding GDP binding purine ribonucleotide binding ion binding ribonucleoside triphosphate phosphatase activity anion binding molecular function regulator activity heterocyclic compound binding carbohydrate derivative binding hydrolase activity, acting on acid anhydrides catalytic activity ribonucleotide binding pyrophosphatase activity GTPase activity nucleoside-triphosphatase regulator activity GTPase regulator activity purine ribonucleoside triphosphate binding guanyl-nucleotide exchange factor activity nucleoside phosphate binding purine nucleotide binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides small molecule binding ubiquitin binding ubiquitin-like protein binding	cellular localization transport intracellular transport establishment of localization vesicle-mediated transport endosomal transport localization late endosome to vacuole transport late endosome to vacuole transport via multivesicular body sorting pathway multivesicular body sorting pathway establishment of localization in cell cellular process vacuolar transport endosome transport via multivesicular body sorting pathway cellular localization transport intracellular transport establishment of localization vesicle-mediated transport endosomal transport localization late endosome to vacuole transport late endosome to vacuole transport via multivesicular body sorting pathway multivesicular body sorting pathway establishment of localization in cell cellular process vacuolar transport endosome transport via multivesicular body sorting pathway cellular component organization organelle organization vacuole organization organelle inheritance vacuole inheritance cellular component organization or biogenesis protein localization establishment of protein localization nitrogen compound transport protein targeting establishment of protein localization to vacuole protein localization to vacuole establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle protein targeting to vacuole intracellular protein transport protein localization to endosome Golgi to endosome transport post-Golgi vesicle-mediated transport cytosolic transport Golgi vesicle transport	membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle cytosol membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle cytosol endocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR041804	Vacuolar protein sorting-associated protein 9, CUE domain	Domain
A	IPR041545	RABX5, catalytic core helical domain	Domain
A	IPR037191	VPS9 domain superfamily	Homologous Superfamily
A	IPR045046	Vacuolar protein sorting-associated protein 9-like	Family
A	IPR009060	UBA-like superfamily	Homologous Superfamily
A	IPR003123	VPS9 domain	Domain
A	IPR003892	Ubiquitin system component CUE	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.