1L5A | pdb_00001l5a

Crystal Structure of VibH, an NRPS Condensation Enzyme

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1l5aa1	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	NRPS condensation domain (amide synthase)	VibH	(Vibrio cholerae ) [TaxId: 666 ],	SCOPe (2.08)
B	d1l5ab1	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	NRPS condensation domain (amide synthase)	VibH	(Vibrio cholerae ) [TaxId: 666 ],	SCOPe (2.08)
C	d1l5ac1	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	NRPS condensation domain (amide synthase)	VibH	(Vibrio cholerae ) [TaxId: 666 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	NRPS condensation domain (amide synthase)	8029758	4002358	SCOP2 (2022-06-29)
A	SCOP2 Family	NRPS condensation domain (amide synthase)	8029759	4002358	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	CoA-dependent acyltransferases	8042137	3000272	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	CoA-dependent acyltransferases	8042138	3000272	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	CoA-dependent acyltransferases	8042138	3000272	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	CoA-dependent acyltransferases	8042137	3000272	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	CoA-dependent acyltransferases	8042137	3000272	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	CoA-dependent acyltransferases	8042138	3000272	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Condensation_N	e1l5aA1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: Condensation_N	ECOD (1.6)
A	Condensation_C_1	e1l5aA2	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: Condensation_C_1	ECOD (1.6)
B	Condensation_N	e1l5aB1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: Condensation_N	ECOD (1.6)
B	Condensation_C_1	e1l5aB2	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: Condensation_C_1	ECOD (1.6)
C	Condensation_N	e1l5aC1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: Condensation_N	ECOD (1.6)
C	Condensation_C_1	e1l5aC2	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: Condensation_C_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
A	6.10.250.80	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
A	3.30.559.30	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Nonribosomal peptide synthetase, condensation domain	CATH (4.3.0)
B	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
B	6.10.250.80	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	3.30.559.30	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Nonribosomal peptide synthetase, condensation domain	CATH (4.3.0)
C	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
C	6.10.250.80	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C	3.30.559.30	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Nonribosomal peptide synthetase, condensation domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00668	Condensation domain (Condensation)	Condensation domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	amide synthase	acid-ammonia (or amide) ligase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity	siderophore biosynthetic process peptide biosynthetic process biosynthetic process secondary metabolite biosynthetic process siderophore metabolic process metabolic process cellular process nonribosomal peptide biosynthetic process peptide metabolic process secondary metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR023213	Chloramphenicol acetyltransferase-like domain superfamily	Homologous Superfamily
A, B, C	IPR001242	Condensation domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.