1L3E | pdb_00001l3e

NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1l3ea1	Peptides	Transactivation domain	Transactivation domain	Transactivation domain	C-terminal activation domain (CTAD) of HIF-1alpha	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1l3ea2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1l3eb_	Small proteins	TAZ domain	TAZ domain	TAZ domain	CREB-binding transcriptional adaptor protein CBP (p300)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	zf-TAZ	e1l3eB1	A: few secondary structure elements	X: TAZ domain (From Topology)	H: TAZ domain (From Topology)	T: TAZ domain	F: zf-TAZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.1020.10	Mainly Alpha	Up-down Bundle	CREB-binding Protein	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08778	HIF-1 alpha C terminal transactivation domain (HIF-1a_CTAD)	HIF-1 alpha C terminal transactivation domain	Hypoxia inducible factor-1 alpha (HIF-1 alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1. It plays a key role in cellular response to low oxygen tension. This region corresponds to the C terminal transactivation domai ...	Hypoxia inducible factor-1 alpha (HIF-1 alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1. It plays a key role in cellular response to low oxygen tension. This region corresponds to the C terminal transactivation domain.	Domain
B	PF02135	TAZ zinc finger (zf-TAZ)	TAZ zinc finger	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	hypoxia inducible factor-1 alpha subunit	histone deacetylase binding protein binding binding enzyme binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity protein domain specific binding kinase binding protein kinase binding histone deacetylase binding protein binding binding enzyme binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity protein domain specific binding kinase binding protein kinase binding transcription factor binding transcription coregulator binding transcription coactivator binding E-box binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding DNA-binding transcription repressor activity p53 binding Hsp90 protein binding heat shock protein binding molecular function activator activity molecular function regulator activity transcription regulator activator activity protein heterodimerization activity protein dimerization activity	response to stimulus response to activity response to muscle activity multicellular organismal process embryonic epithelial tube formation chordate embryonic development neural fold formation tube formation embryo development multicellular organism development epithelial tube formation primary neural tube formation tube morphogenesis neural fold elevation formation response to stimulus response to activity response to muscle activity multicellular organismal process embryonic epithelial tube formation chordate embryonic development neural fold formation tube formation embryo development multicellular organism development epithelial tube formation primary neural tube formation tube morphogenesis neural fold elevation formation embryo development ending in birth or egg hatching anatomical structure development epithelial tube morphogenesis system development developmental process morphogenesis of an epithelial fold morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development tissue morphogenesis anatomical structure morphogenesis neural tube formation anatomical structure formation involved in morphogenesis ossification bone mineralization animal organ development biomineral tissue development cellular developmental process cell development epithelial cell differentiation intestinal epithelial cell maturation columnar/cuboidal epithelial cell development cell differentiation cell maturation digestive system development intestinal epithelial cell differentiation intestinal epithelial cell development developmental maturation digestive tract development epithelial cell development anatomical structure maturation cellular process columnar/cuboidal epithelial cell differentiation epithelial cell maturation columnar/cuboidal epithelial cell maturation ribonucleotide catabolic process pyridine nucleotide catabolic process regulation of cellular process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of primary metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process regulation of purine nucleotide catabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process regulation of nucleobase-containing compound metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process pyruvate metabolic process regulation of biological process purine nucleoside diphosphate metabolic process primary metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process metabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process regulation of metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process biological regulation ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process response to metal ion response to iron ion response to chemical positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process positive regulation of macromolecule biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process positive regulation of metabolic process regulation of RNA metabolic process miRNA transcription positive regulation of biosynthetic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process miRNA metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of miRNA transcription cellular response to stimulus response to oxidative stress cellular response to chemical stimulus cellular response to stress response to stress cellular response to oxidative stress cellular response to chemical stress hemopoiesis embryonic hemopoiesis embryonic organ development mammary gland epithelial cell differentiation mammary gland development gland development epithelial cell differentiation involved in mammary gland alveolus development mammary gland lobule development mammary gland epithelium development mammary gland alveolus development regulation of cytokine production cytokine production regulation of multicellular organismal process regulation of chemokine production positive regulation of gene expression chemokine production positive regulation of chemokine production positive regulation of multicellular organismal process positive regulation of cytokine production negative regulation of metabolic process reactive oxygen species metabolic process negative regulation of biological process negative regulation of reactive oxygen species metabolic process negative regulation of cellular process regulation of reactive oxygen species metabolic process camera-type eye morphogenesis sensory organ development eye development visual system development eye morphogenesis sensory organ morphogenesis camera-type eye development iris morphogenesis animal organ morphogenesis sensory system development glandular epithelial cell development glandular epithelial cell maturation glandular epithelial cell differentiation digestive tract morphogenesis regulation of body fluid levels secretion transport establishment of localization body fluid secretion localization lactation regulation of biological quality negative regulation of mesenchymal cell apoptotic process mesenchymal cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of mesenchymal cell apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death response to decreased oxygen levels cellular response to oxygen levels signaling cellular response to hypoxia cellular response to decreased oxygen levels intracellular signal transduction cell communication response to hypoxia hypoxia-inducible factor-1alpha signaling pathway response to oxygen levels response to abiotic stimulus signal transduction connective tissue development skeletal system development chondrocyte differentiation cartilage development protein metabolic process glycoprotein metabolic process elastin metabolic process response to oxygen-containing compound response to reactive oxygen species response to peptide cellular response to interleukin-1 response to cytokine cellular response to cytokine stimulus response to interleukin-1 establishment of organelle localization cellular localization organelle transport along microtubule establishment of mitochondrion localization intracellular transport axonal transport mitochondrion localization establishment of mitochondrion localization, microtubule-mediated axo-dendritic transport mitochondrion transport along microtubule organelle localization establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process axonal transport of mitochondrion retina vasculature development in camera-type eye retina development in camera-type eye vasculature development circulatory system development positive regulation of phosphate metabolic process positive regulation of nucleotide catabolic process positive regulation of phosphorus metabolic process positive regulation of ATP metabolic process positive regulation of carbohydrate metabolic process positive regulation of nucleotide metabolic process positive regulation of purine nucleotide catabolic process positive regulation of glycolytic process positive regulation of purine nucleotide metabolic process positive regulation of catabolic process positive regulation of small molecule metabolic process positive regulation of cell communication positive regulation of signal transduction regulation of chemokine-mediated signaling pathway response to chemokine regulation of signal transduction positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cellular response to chemokine chemokine-mediated signaling pathway positive regulation of response to stimulus positive regulation of chemokine-mediated signaling pathway regulation of G protein-coupled receptor signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cytokine-mediated signaling pathway positive regulation of G protein-coupled receptor signaling pathway regulation of response to cytokine stimulus regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway positive regulation of cytokine-mediated signaling pathway positive regulation of signaling placenta development in utero embryonic development embryonic placenta development regulation of protein modification process regulation of post-translational protein modification regulation of protein metabolic process regulation of protein neddylation macromolecule modification regulation of protein modification by small protein conjugation or removal protein modification process post-translational protein modification protein neddylation protein modification by small protein conjugation protein modification by small protein conjugation or removal negative regulation of miRNA transcription negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of miRNA metabolic process negative regulation of RNA metabolic process positive regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of blood vessel endothelial cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration cell migration cell motility locomotion neuron apoptotic process collagen metabolic process regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response defense response cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response inflammatory response negative regulation of gene expression cell population proliferation positive regulation of cell population proliferation endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation dopaminergic neuron differentiation generation of neurons neurogenesis neuron differentiation heart development heart morphogenesis outflow tract morphogenesis positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration epithelial cell migration regulation of epithelial cell migration epithelium migration intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis neuroblast proliferation neural precursor cell proliferation glucose homeostasis carbohydrate homeostasis intracellular glucose homeostasis positive regulation of nitric-oxide synthase activity regulation of molecular function positive regulation of molecular function positive regulation of monooxygenase activity regulation of catalytic activity regulation of nitric-oxide synthase activity positive regulation of catalytic activity regulation of oxidoreductase activity positive regulation of oxidoreductase activity cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway regulation of vascular endothelial growth factor receptor signaling pathway cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus vascular endothelial growth factor receptor signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway response to growth factor cardiac chamber morphogenesis cardiac ventricle morphogenesis cardiac chamber development cardiac ventricle development positive regulation of hormone metabolic process regulation of hormone biosynthetic process regulation of hormone metabolic process regulation of hormone levels hormone metabolic process positive regulation of hormone biosynthetic process hormone biosynthetic process intracellular oxygen homeostasis positive regulation of signaling receptor activity regulation of signaling receptor activity head development forebrain development brain development pallium development cerebral cortex development central nervous system development telencephalon development negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of cell communication negative regulation of TOR signaling regulation of intracellular signal transduction TOR signaling regulation of TOR signaling negative regulation of response to stimulus negative regulation of signal transduction mesenchyme development mesenchymal cell differentiation epithelial to mesenchymal transition regulation of developmental process regulation of cell differentiation regulation of cell development positive regulation of developmental process positive regulation of cell differentiation regulation of immune system process myeloid cell homeostasis erythrocyte homeostasis regulation of multicellular organismal development regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells regulation of transforming growth factor beta production regulation of transforming growth factor beta2 production transforming growth factor beta2 production transforming growth factor beta production intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of neuron apoptotic process regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway neuron intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of neuron apoptotic process regulation of apoptotic signaling pathway regulation of growth negative regulation of growth growth cellular respiration aerobic respiration energy derivation by oxidation of organic compounds regulation of cellular respiration regulation of aerobic respiration transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II pattern specification process embryonic heart tube development embryonic heart tube morphogenesis heart looping determination of bilateral symmetry determination of left/right symmetry specification of symmetry embryonic organ morphogenesis determination of heart left/right asymmetry regionalization left/right pattern formation muscle cell cellular homeostasis regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production blood vessel morphogenesis angiogenesis blood vessel development wound healing connective tissue replacement involved in inflammatory response wound healing wound healing involved in inflammatory response inflammatory response to wounding tissue remodeling connective tissue replacement response to wounding lactate metabolic process stem cell development neural crest cell differentiation neural crest cell development mesenchymal cell migration stem cell differentiation neural crest cell migration response to light stimulus system process learning learning or memory nervous system process visual learning visual behavior cognition associative learning behavior response to radiation protein localization establishment of protein localization nitrogen compound transport cellular macromolecule localization establishment of protein localization to extracellular region protein secretion cellular response to oxygen-containing compound cellular response to carbohydrate stimulus response to glucose insulin secretion involved in cellular response to glucose stimulus hormone secretion protein localization to extracellular region peptide secretion secretion by cell response to monosaccharide response to carbohydrate amide transport signal release cellular response to hexose stimulus cellular response to monosaccharide stimulus cell-cell signaling export from cell cellular response to glucose stimulus peptide transport response to hexose protein transport peptide hormone secretion macromolecule localization hormone transport insulin secretion regulation of localization positive regulation of establishment of protein localization positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of insulin secretion regulation of peptide hormone secretion positive regulation of peptide hormone secretion regulation of protein secretion regulation of secretion positive regulation of protein localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion positive regulation of secretion by cell positive regulation of protein transport regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion positive regulation of peptide secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization regulation of protein transport positive regulation of protein secretion positive regulation of transport regulation of cellular localization regulation of insulin secretion regulation of insulin secretion involved in cellular response to glucose stimulus hemoglobin biosynthetic process hemoglobin metabolic process regulation of vasculature development regulation of anatomical structure morphogenesis positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis B cell homeostasis leukocyte homeostasis B-1 B cell homeostasis lymphocyte homeostasis macroautophagy autophagy regulation of autophagy positive regulation of autophagy of mitochondrion mitophagy regulation of autophagy of mitochondrion positive regulation of macroautophagy process utilizing autophagic mechanism positive regulation of autophagy positive regulation of mitophagy regulation of mitophagy regulation of macroautophagy autophagy of mitochondrion negative regulation of thymocyte apoptotic process leukocyte apoptotic process lymphocyte apoptotic process thymocyte apoptotic process negative regulation of leukocyte apoptotic process regulation of T cell apoptotic process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process negative regulation of T cell apoptotic process regulation of thymocyte apoptotic process T cell apoptotic process negative regulation of lymphocyte apoptotic process positive regulation of nervous system development regulation of neuroblast proliferation regulation of neurogenesis regulation of nervous system development positive regulation of neurogenesis regulation of neural precursor cell proliferation positive regulation of cell development positive regulation of neural precursor cell proliferation positive regulation of neuroblast proliferation cellular response to virus biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus negative regulation of biomineral tissue development regulation of biomineral tissue development regulation of bone mineralization negative regulation of bone mineralization negative regulation of developmental process negative regulation of ossification negative regulation of multicellular organismal process regulation of ossification	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol neuron projection cytoplasm axon axon cytoplasm neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection cell projection cilium motile cilium protein-containing complex euchromatin membraneless organelle intracellular membraneless organelle chromatin chromosome RNA polymerase II transcription regulator complex nuclear protein-containing complex transcription regulator complex
B	p300 protein	acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity peptide 2-hydroxyisobutyryltransferase activity N-acyltransferase activity DNA binding binding nucleic acid binding catalytic activity, acting on a protein histone butyryltransferase activity peptide butyryltransferase activity histone modifying activity acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity peptide 2-hydroxyisobutyryltransferase activity N-acyltransferase activity DNA binding binding nucleic acid binding catalytic activity, acting on a protein histone butyryltransferase activity peptide butyryltransferase activity histone modifying activity protein-lysine-acetyltransferase activity protein N-acetyltransferase activity N-acetyltransferase activity histone H3 acetyltransferase activity histone acetyltransferase activity histone H4 acetyltransferase activity histone H4K8 acetyltransferase activity histone H3K14 acetyltransferase activity protein propionyltransferase activity histone propionyltransferase activity histone H4K16 propionyltransferase activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding DNA-binding transcription factor binding nuclear androgen receptor binding histone H2B acetyltransferase activity histone H2BK12 acetyltransferase activity transcription coregulator binding transcription coactivator binding chromatin binding chromatin DNA binding histone H2A acetyltransferase activity histone H2AK5 acetyltransferase activity histone H4K5 acetyltransferase activity beta-catenin binding histone H3K36 acetyltransferase activity histone H3K23 acetyltransferase activity histone H3K56 acetyltransferase activity NF-kappaB binding histone H3K122 acetyltransferase activity STAT family protein binding histone H3K9 acetyltransferase activity cytoskeletal protein binding tau protein binding peptide crotonyltransferase activity histone crotonyltransferase activity L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor L-amino-acid N-acetyltransferase activity histone H3K27 acetyltransferase activity pre-mRNA binding RNA binding pre-mRNA intronic binding p53 binding histone H4K12 acetyltransferase activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity histone H3K4 acetyltransferase activity damaged DNA binding modification-dependent protein binding acetylation-dependent protein binding histone H3K18 acetyltransferase activity histone H2AK9 acetyltransferase activity histone H2BK5 acetyltransferase activity histone H4K16 acetyltransferase activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding peptide lactyltransferase (CoA-dependent) activity histone lactyltransferase (CoA-dependent) activity	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development regulation of protein stability biological regulation regulation of biological quality protein stabilization behavior thigmotaxis developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development regulation of protein stability biological regulation regulation of biological quality protein stabilization behavior thigmotaxis regulation of cellular process positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling positive regulation of macromolecule metabolic process cellular component organization or biogenesis positive regulation of cellular process transcription initiation at RNA polymerase II promoter regulation of biosynthetic process regulation of biological process epigenetic regulation of gene expression primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of gene expression biosynthetic process positive regulation of gene expression transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process peptidyl-lysine acetylation peptidyl-lysine modification protein acylation protein acetylation macromolecule modification peptidyl-amino acid modification protein metabolic process protein modification process positive regulation of DNA-binding transcription factor activity regulation of primary metabolic process positive regulation of molecular function regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of molecular function regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription apoptotic process cell death programmed cell death ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process cell projection organization cell development neuron projection development neurogenesis neuron differentiation positive regulation of neuron projection development cell differentiation positive regulation of cell projection organization plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains response to stimulus regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation positive regulation of T cell differentiation regulation of cell development alpha-beta T cell differentiation involved in immune response positive regulation of immune response T cell activation regulation of T-helper cell differentiation alpha-beta T cell activation regulation of immune system process positive regulation of CD4-positive, alpha-beta T cell differentiation immune response T-helper cell differentiation alpha-beta T cell lineage commitment positive regulation of cell development immune effector process regulation of response to stimulus regulation of leukocyte cell-cell adhesion T-helper 17 cell differentiation cell fate commitment CD4-positive or CD8-positive, alpha-beta T cell lineage commitment positive regulation of alpha-beta T cell differentiation regulation of developmental process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of leukocyte cell-cell adhesion CD4-positive, alpha-beta T cell differentiation positive regulation of T-helper 17 cell differentiation positive regulation of T-helper cell differentiation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation alpha-beta T cell differentiation T cell activation involved in immune response positive regulation of cell differentiation leukocyte activation involved in immune response positive regulation of immune effector process regulation of cell-cell adhesion regulation of T-helper 17 cell differentiation hemopoiesis regulation of cell adhesion cell activation positive regulation of T-helper 17 type immune response regulation of CD4-positive, alpha-beta T cell activation immune system process regulation of lymphocyte activation regulation of immune effector process regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation involved in immune response positive regulation of developmental process positive regulation of cell activation positive regulation of T-helper 17 cell lineage commitment positive regulation of leukocyte activation T cell differentiation positive regulation of adaptive immune response CD4-positive, alpha-beta T cell lineage commitment positive regulation of immune system process positive regulation of T cell activation regulation of adaptive immune response T-helper cell lineage commitment T-helper 17 cell lineage commitment positive regulation of alpha-beta T cell activation regulation of immune response positive regulation of multicellular organismal process leukocyte differentiation regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of response to stimulus positive regulation of CD4-positive, alpha-beta T cell activation cell adhesion regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains cell-cell adhesion alpha-beta T cell activation involved in immune response positive regulation of hemopoiesis CD4-positive, alpha-beta T cell activation regulation of multicellular organismal process lymphocyte activation involved in immune response positive regulation of cell fate commitment regulation of lymphocyte differentiation regulation of multicellular organismal development regulation of T-helper 17 cell lineage commitment regulation of T-helper 17 type immune response regulation of cell fate commitment positive regulation of cell adhesion regulation of T cell activation T cell differentiation involved in immune response T cell lineage commitment adaptive immune response positive T cell selection regulation of hemopoiesis positive regulation of leukocyte differentiation T cell selection positive regulation of lymphocyte differentiation T-helper 17 type immune response viral gene expression biological process involved in interspecies interaction between organisms viral process modulation of process of another organism viral transcription positive regulation by host of viral transcription host-mediated perturbation of symbiont process peptidyl-lysine propionylation fat cell differentiation negative regulation of catabolic process negative regulation of metabolic process autophagy negative regulation of biological process regulation of autophagy negative regulation of autophagy negative regulation of cellular process process utilizing autophagic mechanism negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process multicellular organism growth developmental growth growth cellular response to acid chemical cellular response to stimulus cellular response to nitrogen compound cellular response to amino acid stimulus response to oxygen-containing compound response to nitrogen compound response to amino acid cellular response to L-leucine cellular response to oxygen-containing compound response to acid chemical cellular response to chemical stimulus response to chemical response to L-leucine swimming locomotion rhythmic process circadian rhythm behavioral defense response defense response response to stress somitogenesis epithelium development chordate embryonic development segmentation anterior/posterior pattern specification pattern specification process embryo development tissue development regionalization anatomical structure morphogenesis embryo development ending in birth or egg hatching somite development anatomical structure formation involved in morphogenesis N-terminal peptidyl-lysine acetylation protein maturation N-terminal protein amino acid modification N-terminal protein amino acid acetylation peptidyl-lysine butyrylation peptidyl-lysine crotonylation platelet morphogenesis cell morphogenesis myeloid cell differentiation platelet formation regulation of protein modification process regulation of protein metabolic process macromolecule deacylation protein deacetylation regulation of tubulin deacetylation protein deacylation regulation of protein deacetylation tubulin deacetylation monosaccharide metabolic process negative regulation of small molecule metabolic process gluconeogenesis negative regulation of gluconeogenesis regulation of glucose metabolic process negative regulation of carbohydrate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process hexose biosynthetic process regulation of gluconeogenesis regulation of carbohydrate biosynthetic process glucose metabolic process regulation of signaling signaling regulation of signal transduction signal transduction by p53 class mediator intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator regulation of cell communication signal transduction intracellular receptor signaling pathway response to lipid hormone-mediated signaling pathway cellular response to endogenous stimulus response to hormone response to steroid hormone regulation of intracellular steroid hormone receptor signaling pathway androgen receptor signaling pathway nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus steroid hormone receptor signaling pathway cellular response to hormone stimulus response to endogenous stimulus regulation of androgen receptor signaling pathway cellular response to lipid nuclear receptor-mediated signaling pathway protein destabilization cellular response to nutrient levels response to nutrient levels negative regulation of cellular component organization protein-containing complex organization regulation of cellular component biogenesis negative regulation of protein-containing complex assembly cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly protein localization regulation of localization cellular localization establishment of protein localization nitrogen compound transport regulation of protein localization nucleocytoplasmic transport transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization regulation of protein localization to nucleus positive regulation of protein transport localization import into nucleus regulation of protein import into nucleus cellular macromolecule localization establishment of localization in cell protein import into nucleus positive regulation of intracellular transport regulation of intracellular transport regulation of transport positive regulation of protein localization to nucleus regulation of establishment of protein localization positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of localization establishment of protein localization to organelle positive regulation of transport regulation of cellular localization protein transport macromolecule localization protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport regulation of organelle organization organelle organization regulation of mitochondrion organization mitochondrion organization positive regulation of cell communication positive regulation of signal transduction positive regulation of TORC2 signaling positive regulation of TOR signaling TOR signaling regulation of TOR signaling regulation of TORC2 signaling positive regulation of intracellular signal transduction TORC2 signaling positive regulation of signaling response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus internal protein amino acid acetylation positive regulation of DNA-templated transcription positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process cellular response to heat regulation of cellular response to heat regulation of cellular response to stress response to heat response to temperature stimulus cellular response to stress regulation of response to stress canonical NF-kappaB signal transduction intracellular signaling cassette megakaryocyte differentiation megakaryocyte development myeloid cell development B cell activation B cell differentiation response to estrogen animal organ morphogenesis head development face morphogenesis head morphogenesis face development body morphogenesis cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of transforming growth factor beta receptor signaling pathway enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway tube development respiratory tube development lung development respiratory system development muscle structure development skeletal muscle organ development skeletal muscle tissue development muscle tissue development muscle organ development striated muscle tissue development positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway response to biotic stimulus immune response-activating signaling pathway innate immune response-activating signaling pathway response to other organism immune response-activating cell surface receptor signaling pathway regulation of innate immune response response to external stimulus response to lectin defense response to other organism cellular response to lectin positive regulation of defense response activation of innate immune response activation of immune response regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus innate immune response activating cell surface receptor signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway innate immune response response to external biotic stimulus positive regulation of innate immune response defense response to symbiont stimulatory C-type lectin receptor signaling pathway positive regulation of TORC1 signaling regulation of TORC1 signaling TORC1 signaling response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation cellular response to abiotic stimulus cellular response to UV cell surface receptor signaling pathway via STAT positive regulation of receptor signaling pathway via STAT positive regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT system process learning or memory nervous system process cognition intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator apoptotic signaling pathway DNA damage response intrinsic apoptotic signaling pathway by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway internal peptidyl-lysine acetylation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome catalytic complex transferase complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome catalytic complex transferase complex histone acetyltransferase complex acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-DNA complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013655	PAS fold-3	Domain
A	IPR001321	Hypoxia-inducible factor-1 alpha	Family
A	IPR035965	PAS domain superfamily	Homologous Superfamily
A	IPR014887	HIF-1 alpha, C-terminal transactivation domain	Domain
A	IPR000014	PAS domain	Domain
A	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
A	IPR001610	PAC motif	Repeat
A	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily
A	IPR021537	Hypoxia-inducible factor, alpha subunit-like	Domain
A	IPR013767	PAS fold	Domain
B	IPR043145	Zinc finger, ZZ-type superfamily	Homologous Superfamily
B	IPR018359	Bromodomain, conserved site	Conserved Site
B	IPR036529	Coactivator CBP, KIX domain superfamily	Homologous Superfamily
B	IPR009110	Nuclear receptor coactivator, interlocking	Homologous Superfamily
B	IPR000433	Zinc finger, ZZ-type	Domain
B	IPR013178	Histone acetyltransferase Rtt109/CBP	Family
B	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
B	IPR010303	CREB-binding protein/p300, atypical RING domain	Domain
B	IPR037073	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily	Homologous Superfamily
B	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking	Domain
B	IPR038547	CBP/p300, atypical RING domain superfamily	Homologous Superfamily
B	IPR000197	Zinc finger, TAZ-type	Domain
B	IPR003101	Coactivator CBP, KIX domain	Domain
B	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
B	IPR001487	Bromodomain	Domain
B	IPR035898	TAZ domain superfamily	Homologous Superfamily
B	IPR031162	CBP/p300-type histone acetyltransferase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q16665	glioblastoma sclerosing cholangitis breast carcinoma hypertensive disorder astrocytic tumor esophageal squamous cell carcinoma hemangioblastoma primary biliary cholangitis Neoplasm Invasiveness thyroid adenoma hyperplasia childhood cerebral astrocytoma pilocytic astrocytoma primary sclerosing cholangitis lung disease glioblastoma sclerosing cholangitis breast carcinoma hypertensive disorder astrocytic tumor esophageal squamous cell carcinoma hemangioblastoma primary biliary cholangitis Neoplasm Invasiveness thyroid adenoma hyperplasia childhood cerebral astrocytoma pilocytic astrocytoma primary sclerosing cholangitis lung disease pulmonary hypertension ductal breast carcinoma in situ malignant pancreatic neoplasm gemistocytic astrocytoma idiopathic pulmonary fibrosis prostate cancer protoplasmic astrocytoma brain ischemia skin cancer fibrillary astrocytoma carcinoma giant cell glioblastoma subependymal giant cell astrocytoma thyroid gland carcinoma anaplastic astrocytoma juvenile pilocytic astrocytoma congestive heart failure sarcomatoid carcinoma skin neoplasm breast ductal adenocarcinoma gastric carcinoma heart failure oligodendroglioma amyotrophic lateral sclerosis ovarian disease kidney disease dermatomyositis diffuse astrocytoma major depressive disorder brain hypoxia - ischemia erythropoietin polycythemia small cell lung carcinoma familial polycythemia cancer spinal cord injury stomach disease cerebral astrocytoma thyroid cancer osteosarcoma cerebrovascular disorder ulcerative colitis pancreatic ductal adenocarcinoma colonic disease juvenile dermatomyositis congenital heart disease B-cell chronic lymphocytic leukemia bipolar disorder breast disease myopathy ovarian cancer cervical cancer undifferentiated carcinoma inborn carbohydrate metabolic disorder pancreatic neoplasm liver disease astrocytoma (excluding glioblastoma) prostate disease diabetes mellitus lymphatic system disease psoriasis Duchenne muscular dystrophy bone disease Emery-Dreifuss muscular dystrophy breast cancer
B	Pharos: Q09472	Rubinstein-Taybi syndrome Stevens-Johnson syndrome transitional cell carcinoma melanoma esophageal squamous cell carcinoma urinary bladder cancer Rubinstein-Taybi syndrome due to EP300 haploinsufficiency endometrial carcinoma acute myeloid leukemia salivary gland adenoid cystic carcinoma small cell lung carcinoma obesity disorder breast carcinoma colorectal cancer Craniofacial Abnormalities Rubinstein-Taybi syndrome Stevens-Johnson syndrome transitional cell carcinoma melanoma esophageal squamous cell carcinoma urinary bladder cancer Rubinstein-Taybi syndrome due to EP300 haploinsufficiency endometrial carcinoma acute myeloid leukemia salivary gland adenoid cystic carcinoma small cell lung carcinoma obesity disorder breast carcinoma colorectal cancer Craniofacial Abnormalities squamous cell carcinoma T-cell non-Hodgkin lymphoma adenoid cystic carcinoma exocrine pancreatic carcinoma toxic epidermal necrolysis lung adenocarcinoma urinary bladder neoplasm adrenoleukodystrophy benign neoplasm of pancreas osteogenesis imperfecta breast cancer pancreatic intraductal papillary-mucinous carcinoma colorectal adenocarcinoma rheumatoid arthritis cutaneous melanoma endogenous depression hematologic disease lymphoplasmacytic lymphoma bipolar disorder osteosarcoma pancreatic intraductal papillary-mucinous neoplasm prostate cancer diffuse large B-cell lymphoma small cell carcinoma endometrial cancer intellectual disability malignant glioma autism spectrum disorder osteoarthritis breast adenocarcinoma ovarian cancer cancer pancreatic neoplasm colorectal carcinoma psoriasis Crohn disease