1K78 | pdb_00001k78

Pax5(1-149)+Ets-1(331-440)+DNA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
I	d1k78i1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Paired domain	Pax-5	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth A]	d1k78a1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Paired domain	Pax-5	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth E]	d1k78e1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Paired domain	Pax-5	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth B]	d1k78b_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	ets domain	ETS-1 transcription factor, residues 331-440	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
H [auth F]	d1k78f_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	ets domain	ETS-1 transcription factor, residues 331-440	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
I	SCOP2B Superfamily	Homeodomain-like	8057627	3000001	SCOP2B (2022-06-29)
E [auth A]	SCOP2 Family	Paired domain	8002437	4000325	SCOP2 (2022-06-29)
E [auth A]	SCOP2 Superfamily	Homeodomain-like	8057627	3000001	SCOP2 (2022-06-29)
E [auth A]	SCOP2 Superfamily	Homeodomain-like	8057626	3000001	SCOP2 (2022-06-29)
G [auth E]	SCOP2B Superfamily	Homeodomain-like	8057626	3000001	SCOP2B (2022-06-29)
G [auth E]	SCOP2B Superfamily	Homeodomain-like	8057627	3000001	SCOP2B (2022-06-29)
F [auth B]	SCOP2B Superfamily	Winged helix DNA-binding domain	8056283	3000034	SCOP2B (2022-06-29)
H [auth F]	SCOP2B Superfamily	Winged helix DNA-binding domain	8056283	3000034	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
I	PAX_C	e1k78I1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PAX_C	ECOD (1.6)
E [auth A]	PAX_C	e1k78A2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PAX_C	ECOD (1.6)
E [auth A]	PAX_N	e1k78A1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PAX_N	ECOD (1.6)
G [auth E]	PAX_C	e1k78E2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PAX_C	ECOD (1.6)
G [auth E]	PAX_N	e1k78E1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PAX_N	ECOD (1.6)
F [auth B]	Ets	e1k78B1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Ets	ECOD (1.6)
H [auth F]	Ets	e1k78F1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Ets	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
I	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
E [auth A]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
G [auth E]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
F [auth B]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
H [auth F]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
F [auth B], H [auth F]	PF00178	Ets-domain (Ets)	Ets-domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
E [auth A], G [auth E], I	Paired Box Protein Pax5	DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity	developmental process sensory organ development animal organ development anatomical structure development multicellular organismal process head development forebrain development brain development nervous system development pallium development cerebral cortex development multicellular organism development central nervous system development telencephalon development developmental process sensory organ development animal organ development anatomical structure development multicellular organismal process head development forebrain development brain development nervous system development pallium development cerebral cortex development multicellular organism development central nervous system development telencephalon development system development spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation cellular developmental process hemopoiesis B cell activation cell activation cell development mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation cell differentiation immune system process cellular process leukocyte differentiation RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process macromolecule metabolic process embryonic organ morphogenesis embryonic cranial skeleton morphogenesis chordate embryonic development embryonic morphogenesis embryo development anatomical structure morphogenesis embryo development ending in birth or egg hatching skeletal system development cranial skeletal system development animal organ morphogenesis embryonic skeletal system development skeletal system morphogenesis embryonic organ development embryonic skeletal system morphogenesis behavior adult behavior lateral ventricle development ventricular system development regulation of cellular process regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of biological process biological regulation regulation of macromolecule metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of biological process negative regulation of RNA biosynthetic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process skeletal muscle cell differentiation skeletal muscle tissue development tissue development striated muscle tissue development muscle structure development skeletal muscle organ development muscle tissue development muscle organ development	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle intracellular membraneless organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle intracellular membraneless organelle chromatin chromosome
A [auth C], C [auth G]	Pax5/Ets Binding Site on the mb-1 promoter	-	-	-
B [auth D], D [auth H]	Pax5/Ets Binding Site on the mb-1 promoter	-	-	-
F [auth B], H [auth F]	C-ets-1 Protein	binding nucleic acid binding transcription regulator activity DNA-binding transcription factor activity sequence-specific DNA binding DNA binding transcription factor binding protein binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding double-stranded DNA binding	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis regulation of angiogenesis anatomical structure formation involved in morphogenesis anatomical structure development regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development positive regulation of locomotion regulation of cell motility regulation of cellular process endothelial cell migration positive regulation of biological process positive regulation of cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration cellular process cell motility locomotion positive regulation of cellular process regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus negative regulation of biological process response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response immune system process cellular developmental process homeostatic process cell development regulation of cell differentiation regulation of cell development positive regulation of developmental process positive regulation of cell differentiation cell differentiation regulation of immune system process myeloid cell homeostasis erythrocyte homeostasis hemopoiesis regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II	protein-containing complex transcription regulator complex cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth A], G [auth E], I	IPR009057	Homedomain-like superfamily	Homologous Superfamily
E [auth A], G [auth E], I	IPR043182	Paired DNA-binding domain	Domain
E [auth A], G [auth E], I	IPR043565	PAX family	Family
E [auth A], G [auth E], I	IPR022130	Paired-box protein 2 C-terminal	Domain
E [auth A], G [auth E], I	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
E [auth A], G [auth E], I	IPR001523	Paired domain	Domain
F [auth B], H [auth F]	IPR041886	Protein C-ets-1, pointed domain	Domain
F [auth B], H [auth F]	IPR045688	Ets1, N-terminal flanking region of Ets domain	Domain
F [auth B], H [auth F]	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
F [auth B], H [auth F]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
F [auth B], H [auth F]	IPR000418	Ets domain	Domain
F [auth B], H [auth F]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
F [auth B], H [auth F]	IPR016311	Transforming protein C-ets	Family
F [auth B], H [auth F]	IPR046328	ETS family	Family
F [auth B], H [auth F]	IPR003118	Pointed domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth A], G [auth E], I	Pharos: Q02548	Neurodevelopmental Disorders cancer leukemia, acute lymphocytic, susceptibility to, 1 ovarian cancer Sjogren syndrome attention deficit hyperactivity disorder, inattentive type endogenous depression interstitial cystitis medulloblastoma non-Hodgkin lymphoma tuberculosis bipolar disorder childhood acute lymphoblastic leukemia hematologic disease large cell medulloblastoma Neurodevelopmental Disorders cancer leukemia, acute lymphocytic, susceptibility to, 1 ovarian cancer Sjogren syndrome attention deficit hyperactivity disorder, inattentive type endogenous depression interstitial cystitis medulloblastoma non-Hodgkin lymphoma tuberculosis bipolar disorder childhood acute lymphoblastic leukemia hematologic disease large cell medulloblastoma nasopharyngeal carcinoma osteosarcoma psoriasis ulcerative colitis Burkitt lymphoma cutaneous lupus erythematosus hematopoietic and lymphoid system neoplasm lymphatic system disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.