1K76 | pdb_00001k76

Solution Structure of the C-terminal Sem-5 SH3 Domain (Minimized Average Structure)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1k76a_	All beta proteins	SH3-like barrel	SH3-domain	SH3-domain	Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SH3-domain	8041622	3000153	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH3_1	e1k76A1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00018	SH3 domain (SH3_1)	SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SEX MUSCLE ABNORMAL PROTEIN 5	epidermal growth factor receptor binding protein binding binding signaling receptor binding growth factor receptor binding phosphoprotein binding phosphotyrosine residue binding protein phosphorylated amino acid binding	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell surface receptor protein tyrosine kinase signaling pathway cell communication ERBB signaling pathway epidermal growth factor receptor signaling pathway cellular process signal transduction enzyme-linked receptor protein signaling pathway cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell surface receptor protein tyrosine kinase signaling pathway cell communication ERBB signaling pathway epidermal growth factor receptor signaling pathway cellular process signal transduction enzyme-linked receptor protein signaling pathway developmental process multicellular organismal process regulation of multicellular organismal development regulation of developmental process nematode larval development larval development multicellular organism development regulation of post-embryonic development regulation of nematode larval development anatomical structure development post-embryonic development regulation of multicellular organismal process regulation of signaling regulation of signal transduction regulation of MAPK cascade intracellular signal transduction regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette MAPK cascade regulation of cell communication vulval development animal organ development regulation of vulval development muscle structure development muscle organ development cellular component organization regulation of cellular component organization cell projection organization regulation of cell projection organization cellular component organization or biogenesis genitalia development reproductive system development reproductive process sex differentiation developmental process involved in reproduction male sex differentiation male genitalia development reproductive structure development system development regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion	cell periphery cellular anatomical structure plasma membrane membrane membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure organelle nucleus nuclear protein-containing complex COP9 signalosome intracellular membrane-bounded organelle cytoplasm cell periphery cellular anatomical structure plasma membrane membrane membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure organelle nucleus nuclear protein-containing complex COP9 signalosome intracellular membrane-bounded organelle cytoplasm membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR043539	Grb2-like	Family
A	IPR036860	SH2 domain superfamily	Homologous Superfamily
A	IPR000980	SH2 domain	Domain
A	IPR001452	SH3 domain	Domain
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.