1IV6 | pdb_00001iv6

Solution Structure of the DNA Complex of Human TRF1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d1iv6a_	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	DNA-binding domain of telomeric protein	DNA-binding domain of human telomeric protein, hTRF1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2B Superfamily	Homeodomain-like	8057625	3000001	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	Myb_DNA-binding	e1iv6A1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: Myb_DNA-binding	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A]	PF00249	Myb-like DNA-binding domain (Myb_DNA-binding)	Myb-like DNA-binding domain	This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	5'-D(GPTPTPAPGPGPGPTPTPAPGPGP*G)-3'	-	-	-
B [auth C]	5'-D(CPCPCPTPAPAPCPCPCPTPAPAP*C)-3'	-	-	-
C [auth A]	TELOMERIC REPEAT BINDING FACTOR 1	ankyrin repeat binding protein binding binding protein domain specific binding sequence-specific DNA binding DNA binding nucleic acid binding telomeric DNA binding double-stranded telomeric DNA binding double-stranded DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding ankyrin repeat binding protein binding binding protein domain specific binding sequence-specific DNA binding DNA binding nucleic acid binding telomeric DNA binding double-stranded telomeric DNA binding double-stranded DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding cytoskeletal protein binding microtubule binding tubulin binding identical protein binding protein homodimerization activity protein dimerization activity DNA binding, bending	regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization regulation of shelterin complex assembly positive regulation of biological process telomere organization positive regulation of shelterin complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly shelterin complex assembly protein-containing complex assembly regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization regulation of shelterin complex assembly positive regulation of biological process telomere organization positive regulation of shelterin complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly shelterin complex assembly protein-containing complex assembly cellular component organization or biogenesis positive regulation of cellular process regulation of biological process protein-containing complex organization positive regulation of cellular component biogenesis biological regulation chromosome organization protein-DNA complex assembly regulation of cellular component biogenesis organelle organization cellular process response to stimulus response to chemical response to xenobiotic stimulus establishment of organelle localization meiotic chromosome segregation cellular localization sexual reproduction reproductive process meiotic cell cycle process localization telomere localization meiosis I chromosome localization organelle localization establishment of localization in cell meiotic nuclear division cell cycle chromosome segregation cell cycle process meiotic cell cycle organelle fission meiotic telomere clustering establishment of localization chromosome organization involved in meiotic cell cycle nuclear division chromosome localization to nuclear envelope involved in homologous chromosome segregation meiosis I cell cycle process nuclear chromosome segregation homologous chromosome segregation establishment of chromosome localization telomere maintenance via telomerase primary metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA-templated DNA biosynthetic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening telomere maintenance nucleic acid biosynthetic process biosynthetic process metabolic process macromolecule metabolic process DNA biosynthetic process cell division regulation of establishment of protein-containing complex localization to telomere regulation of localization establishment of protein-containing complex localization to telomere negative regulation of biological process protein-containing complex localization negative regulation of establishment of protein-containing complex localization to telomere cellular macromolecule localization macromolecule localization regulation of establishment of RNA localization to telomere negative regulation of establishment of RNA localization to telomere establishment of RNA localization to telomere establishment of RNA localization RNA localization formation of extrachromosomal circular DNA telomere maintenance via telomere trimming t-circle formation telomeric loop disassembly telomeric D-loop disassembly negative regulation of telomere maintenance negative regulation of telomere maintenance via telomerase regulation of DNA biosynthetic process regulation of primary metabolic process negative regulation of chromosome organization negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of cellular component organization negative regulation of metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process negative regulation of DNA biosynthetic process regulation of DNA metabolic process regulation of telomere maintenance negative regulation of telomere maintenance via telomere lengthening negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process regulation of telomere maintenance via telomerase negative regulation of organelle organization negative regulation of biosynthetic process negative regulation of DNA metabolic process negative regulation of telomere maintenance via semi-conservative replication negative regulation of cell cycle cell cycle DNA replication telomere maintenance via semi-conservative replication regulation of cell cycle process DNA replication nuclear DNA replication regulation of cell cycle DNA-templated DNA replication negative regulation of cell cycle process regulation of telomere maintenance via semi-conservative replication regulation of telomeric loop disassembly regulation of telomeric D-loop disassembly negative regulation of telomeric D-loop disassembly negative regulation of telomeric loop disassembly positive regulation of organelle organization positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process positive regulation of chromosome organization positive regulation of DNA metabolic process telomere capping protein localization establishment of protein localization to telomere establishment of protein localization regulation of protein localization negative regulation of protein localization to chromosome, telomeric region regulation of protein localization to chromosome, telomeric region establishment of protein localization to chromosome regulation of establishment of protein localization to chromosome negative regulation of protein localization regulation of establishment of protein localization negative regulation of establishment of protein localization protein localization to chromosome, telomeric region negative regulation of establishment of protein localization to telomere establishment of protein localization to organelle protein localization to chromosome regulation of cellular localization protein localization to organelle regulation of establishment of protein localization to telomere negative regulation of hydrolase activity regulation of catalytic activity negative regulation of molecular function negative regulation of catalytic activity regulation of molecular function regulation of hydrolase activity negative regulation of exonuclease activity negative regulation of nuclease activity negative regulation of DNA replication regulation of DNA replication	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen protein-containing complex protein-DNA complex nuclear protein-containing complex chromosome chromosomal region telomere cap complex chromosome, telomeric repeat region chromosome, telomeric region shelterin complex nuclear telomere cap complex cytoplasm nucleoplasm fibrillar center cytoskeleton spindle microtubule cytoskeleton nuclear body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A]	IPR017930	Myb domain	Domain
C [auth A]	IPR052450	Telomeric Repeat-Binding Domain-Containing Protein	Family
C [auth A]	IPR013867	Telomere repeat-binding factor, dimerisation domain	Domain
C [auth A]	IPR009057	Homedomain-like superfamily	Homologous Superfamily
C [auth A]	IPR036507	Telomere repeat-binding factor, dimerisation domain superfamily	Homologous Superfamily
C [auth A]	IPR017357	Telomeric repeat-binding factor 1/2	Family
C [auth A]	IPR001005	SANT/Myb domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth A]	Pharos: P54274	Crohn disease ovarian cancer ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.