1D7Q | pdb_00001d7q

HUMAN TRANSLATION INITIATION FACTOR EIF1A

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth A]	d1d7qa_	All beta proteins	OB-fold	Nucleic acid-binding proteins	Cold shock DNA-binding domain-like	Translation initiation factor-1a, eIF1a	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2 Family	Cold shock DNA-binding domain-like	8029569	4001909	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	Nucleic acid-binding proteins	8041948	3000135	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	eIF-1a	e1d7qA1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: eIF-1a	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth A]	PF01176	Translation initiation factor 1A / IF-1 (eIF-1a)	Translation initiation factor 1A / IF-1	This family includes both the eukaryotic translation factor eIF-1A and the bacterial translation initiation factor IF-1.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	PROTEIN (N-TERMINAL HISTIDINE TAG)	-	-	-
B [auth A]	TRANSLATION INITIATION FACTOR 1A	translation factor activity translation initiation factor activity RNA binding binding nucleic acid binding translation factor activity, RNA binding tRNA binding	biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process ribonucleoprotein complex biogenesis organelle assembly membraneless organelle assembly cellular component biogenesis biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process ribonucleoprotein complex biogenesis organelle assembly membraneless organelle assembly cellular component biogenesis cellular component organization ribosome biogenesis organelle organization cellular component assembly cellular component organization or biogenesis ribosome assembly	protein-containing complex cellular anatomical structure intracellular anatomical structure eukaryotic 43S preinitiation complex ribonucleoprotein complex cytosolic translation preinitiation complex cytoplasm multi-eIF complex synapse cell junction cytosol eukaryotic 48S preinitiation complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth A]	IPR018104	Translation initiation factor 1A (eIF-1A), conserved site	Conserved Site
B [auth A]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
B [auth A]	IPR006196	RNA-binding domain, S1, IF1 type	Domain
B [auth A]	IPR001253	Translation initiation factor 1A (eIF-1A)	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth A]	Pharos: P47813	uveal melanoma Neoplasm Metastasis atypical teratoid rhabdoid tumor ovarian cancer sarcoidosis breast cancer ocular melanoma pancreatic intraductal papillary-mucinous neoplasm thyroid gland papillary carcinoma lung cancer osteosarcoma psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.