1D7M | pdb_00001d7m

COILED-COIL DIMERIZATION DOMAIN FROM CORTEXILLIN I

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1d7ma_	Coiled coil proteins	Parallel coiled-coil	Coiled-coil dimerization domain from cortexillin I	Coiled-coil dimerization domain from cortexillin I	Coiled-coil dimerization domain from cortexillin I	(Dictyostelium discoideum ) [TaxId: 44689 ],	SCOPe (2.08)
B	d1d7mb_	Coiled coil proteins	Parallel coiled-coil	Coiled-coil dimerization domain from cortexillin I	Coiled-coil dimerization domain from cortexillin I	Coiled-coil dimerization domain from cortexillin I	(Dictyostelium discoideum ) [TaxId: 44689 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Coiled-coil dimerization domain from cortexillin I	8026075	4003785	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Coiled-coil dimerization domain from cortexillin I	8038454	3001492	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Coiled-coil dimerization domain from cortexillin I	8038454	3001492	SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.340	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	1.20.5.340	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF09304	Cortexillin coiled-coil region (Cortex-I_coil)	Cortexillin coiled-coil region	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CORTEXILLIN I	protein binding binding alpha-catenin binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding protein binding binding alpha-catenin binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding enzyme regulator activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups molecular function regulator activity catalytic activity kinase regulator activity identical protein binding	membrane organization cytoskeleton-dependent cytokinesis cytokinesis cleavage furrow formation cellular component organization cytokinetic process membrane invagination cellular process cell cycle cell division cellular component organization or biogenesis plasma membrane invagination cell cycle process mitotic cell cycle process membrane organization cytoskeleton-dependent cytokinesis cytokinesis cleavage furrow formation cellular component organization cytokinetic process membrane invagination cellular process cell cycle cell division cellular component organization or biogenesis plasma membrane invagination cell cycle process mitotic cell cycle process mitotic cytokinesis mitotic cell cycle protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular component biogenesis bleb assembly cellular component assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cell projection assembly chemotaxis response to stimulus chemotaxis to cAMP taxis response to chemical response to external stimulus locomotion regulation of localization protein localization to cell periphery regulation of biological process regulation of cellular process regulation of protein localization biological regulation negative regulation of biological process regulation of protein localization to cell periphery negative regulation of protein localization to cell cortex regulation of cellular localization regulation of protein localization to cell cortex negative regulation of protein localization to cell periphery negative regulation of cellular process protein localization to cell cortex negative regulation of protein localization regulation of biosynthetic process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process sexual reproduction reproductive process detection of external stimulus detection of stimulus detection of mechanical stimulus response to mechanical stimulus response to abiotic stimulus detection of abiotic stimulus cellular response to stimulus developmental process response to nutrient levels biological process involved in intraspecies interaction between organisms aggregation involved in sorocarp development cellular response to starvation cellular response to nutrient levels sorocarp development cellular response to stress response to stress anatomical structure development response to starvation socially cooperative development positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization positive regulation of cellular component organization positive regulation of cytoskeleton organization regulation of organelle organization organelle organization cytoskeleton organization protein localization to cell division site localization within membrane protein localization to membrane protein localization to cleavage furrow actin cytoskeleton organization actomyosin structure organization cortical cytoskeleton organization contractile ring contraction cortical actin cytoskeleton organization actomyosin contractile ring contraction actin filament-based process actomyosin contractile ring organization regulation of actin filament-based process myosin filament assembly myosin II filament assembly regulation of myosin II filament assembly regulation of protein-containing complex assembly protein-containing complex assembly protein-containing complex organization myosin filament organization regulation of myosin II filament organization regulation of cellular component biogenesis myosin II filament organization regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization signaling adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway anatomical structure morphogenesis cell morphogenesis biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external biotic stimulus response to biotic stimulus actin filament organization actin crosslink formation actin filament bundle organization actin filament bundle assembly sorocarp stalk development sorocarp stalk morphogenesis culmination involved in sorocarp development sorocarp morphogenesis	cell periphery cellular anatomical structure cell cortex intracellular anatomical structure basal part of cell cell cortex region cytoplasm cytoplasmic region basal cortex membrane-bounded organelle organelle vesicle intracellular organelle cytoskeleton cell periphery cellular anatomical structure cell cortex intracellular anatomical structure basal part of cell cell cortex region cytoplasm cytoplasmic region basal cortex membrane-bounded organelle organelle vesicle intracellular organelle cytoskeleton membraneless organelle intracellular membraneless organelle actin cytoskeleton cytosol contractile ring cell division site cortical cytoskeleton actomyosin contractile ring cortical actin cytoskeleton cell leading edge cell trailing edge intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle cytoplasmic vesicle endocytic vesicle plasma membrane membrane cleavage furrow plasma membrane region lateral part of motile cell lateral part of cell mitotic spindle spindle mitotic spindle midzone spindle midzone microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001715	Calponin homology domain	Domain
A, B	IPR001589	Actinin-type actin-binding domain, conserved site	Conserved Site
A, B	IPR036872	CH domain superfamily	Homologous Superfamily
A, B	IPR015383	Cortexillin, coiled coil	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.