1BQU

CYTOKYNE-BINDING REGION OF GP130

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1bqua1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	Fibronectin type III	Cytokine receptor gp130 cytokine-binding domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1bqub1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	Fibronectin type III	Cytokine receptor gp130 cytokine-binding domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Fibronectin type III	8055144	4007555	SCOP2 (2022-06-29)
A	SCOP2 Family	Fibronectin type III	8055532	4007555	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Fibronectin type III	8055145	3002063	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Fibronectin type III	8055533	3002063	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Fibronectin type III	8055145	3002063	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Fibronectin type III	8055533	3002063	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IL6Ra-bind	e1bquA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IL6Ra-bind	ECOD (1.6)
A	fn3_6	e1bquA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3_6	ECOD (1.6)
B	IL6Ra-bind	e1bquB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IL6Ra-bind	ECOD (1.6)
B	fn3_6	e1bquB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3_6	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, B	IL6ST (Interleukin-6 receptor subunit beta)	2F-DOMAIN	Homo sapiens (human)	IL6ST	F-LIKE-DOMAIN F-DOMAIN	RPI	2F-DOMAIN	IMGT (202452-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00041	Fibronectin type III domain (fn3)	Fibronectin type III domain	-	Domain
A, B	PF09240	Interleukin-6 receptor alpha chain, binding (IL6Ra-bind)	Interleukin-6 receptor alpha chain, binding	Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PROTEIN (GP130)	protein tyrosine kinase activator activity enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity molecular transducer activity coreceptor activity signaling receptor activity interleukin-11 receptor activity transmembrane signaling receptor activity protein tyrosine kinase activator activity enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity molecular transducer activity coreceptor activity signaling receptor activity interleukin-11 receptor activity transmembrane signaling receptor activity cytokine receptor activity immune receptor activity identical protein binding protein binding binding ciliary neurotrophic factor receptor binding signaling receptor binding cytokine receptor binding interleukin-11 binding growth factor binding cytokine binding scaffold protein binding interleukin-27 receptor activity interleukin-17 receptor activity ciliary neurotrophic factor receptor activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus cellular process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus cellular process signal transduction immune response regulation of adaptive immune response positive regulation of biological process adaptive immune response positive regulation of response to stimulus regulation of response to stimulus positive regulation of immune response immune system process regulation of immune response regulation of immune system process positive regulation of adaptive immune response positive regulation of immune system process cell surface receptor signaling pathway via STAT regulation of defense response regulation of response to external stimulus defense response response to external stimulus regulation of inflammatory response positive regulation of acute inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response response to stress regulation of response to stress positive regulation of defense response regulation of acute inflammatory response inflammatory response acute inflammatory response multicellular organismal process regulation of body fluid levels homotypic cell-cell adhesion regulation of cell activation positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion coagulation regulation of cell-cell adhesion regulation of multicellular organismal process regulation of biological quality response to wounding positive regulation of cellular process wound healing regulation of homotypic cell-cell adhesion positive regulation of cell adhesion regulation of cell adhesion cell activation hemostasis platelet aggregation blood coagulation regulation of platelet activation regulation of platelet aggregation positive regulation of homotypic cell-cell adhesion positive regulation of platelet aggregation platelet activation leukemia inhibitory factor signaling pathway enzyme-linked receptor protein signaling pathway developmental process epithelium development digestive system development cellular developmental process intestinal epithelial cell differentiation tube development intestinal epithelial cell development cell development tissue development digestive tract development epithelial cell differentiation multicellular organism development epithelial cell development columnar/cuboidal epithelial cell development cell differentiation anatomical structure development columnar/cuboidal epithelial cell differentiation system development muscle hypertrophy regulation of muscle adaptation system process positive regulation of cardiac muscle hypertrophy regulation of system process striated muscle hypertrophy regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy regulation of muscle hypertrophy muscle adaptation positive regulation of muscle hypertrophy cardiac muscle hypertrophy positive regulation of multicellular organismal process positive regulation of cell population proliferation regulation of leukocyte activation positive regulation of cell activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of leukocyte proliferation cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation positive regulation of lymphocyte activation positive regulation of mononuclear cell proliferation T cell proliferation regulation of lymphocyte proliferation regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production positive regulation of macromolecule metabolic process regulation of vascular endothelial growth factor production regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression vascular endothelial growth factor production biosynthetic process positive regulation of gene expression positive regulation of vascular endothelial growth factor production regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death ciliary neurotrophic factor-mediated signaling pathway neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process interleukin-6-mediated signaling pathway response to interleukin-6 cellular response to interleukin-6 regulation of osteoblast differentiation regulation of developmental process regulation of cell differentiation osteoblast differentiation positive regulation of developmental process positive regulation of osteoblast differentiation ossification positive regulation of cell differentiation interleukin-27-mediated signaling pathway positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction regulation of signaling Notch signaling pathway regulation of Notch signaling pathway regulation of cell communication positive regulation of Notch signaling pathway positive regulation of signaling interleukin-11-mediated signaling pathway negative regulation of signaling negative regulation of cell communication negative regulation of response to stimulus negative regulation of interleukin-6-mediated signaling pathway regulation of cytokine-mediated signaling pathway negative regulation of signal transduction regulation of interleukin-6-mediated signaling pathway regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus negative regulation of cytokine-mediated signaling pathway carbohydrate metabolic process energy derivation by oxidation of organic compounds glycogen metabolic process primary metabolic process generation of precursor metabolites and energy glucan metabolic process polysaccharide metabolic process energy reserve metabolic process oncostatin-M-mediated signaling pathway positive regulation of nervous system development astrocyte differentiation regulation of neurogenesis regulation of gliogenesis regulation of astrocyte differentiation positive regulation of gliogenesis regulation of cell development regulation of nervous system development neurogenesis gliogenesis positive regulation of neurogenesis positive regulation of astrocyte differentiation regulation of multicellular organismal development positive regulation of cell development regulation of glial cell differentiation nervous system development positive regulation of glial cell differentiation central nervous system development glial cell differentiation CD4-positive or CD8-positive, alpha-beta T cell lineage commitment adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains mononuclear cell differentiation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation T cell activation involved in immune response alpha-beta T cell activation involved in immune response CD4-positive, alpha-beta T cell activation leukocyte activation involved in immune response alpha-beta T cell activation T cell differentiation CD4-positive, alpha-beta T cell lineage commitment lymphocyte activation involved in immune response T-helper cell differentiation alpha-beta T cell lineage commitment hemopoiesis T-helper cell lineage commitment T cell differentiation involved in immune response T cell lineage commitment immune effector process T-helper 17 cell lineage commitment positive T cell selection T cell selection T-helper 17 cell differentiation cell fate commitment leukocyte differentiation T-helper 17 type immune response	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex ciliary neurotrophic factor receptor complex membrane protein complex receptor complex somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection interleukin-6 receptor complex oncostatin-M receptor complex cell body neuronal cell body membrane microdomain membrane raft

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR003529	Long hematopoietin receptor, Gp130 family 2, conserved site	Conserved Site
A, B	IPR050379	Type I Cytokine Receptor	Family
A, B	IPR010457	Immunoglobulin C2-set-like, ligand-binding	Domain
A, B	IPR015321	Type I cytokine receptor, cytokine-binding domain	Domain
A, B	IPR003961	Fibronectin type III	Domain
A, B	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P40189	rheumatoid arthritis ovarian cancer colorectal cancer allergic disease prostate cancer Mammary Neoplasms, Experimental sarcomatoid carcinoma middle cerebral artery infarction pneumonia carcinoma non-small cell lung carcinoma Gaucher disease invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous carcinoma juvenile idiopathic arthritis rheumatoid arthritis ovarian cancer colorectal cancer allergic disease prostate cancer Mammary Neoplasms, Experimental sarcomatoid carcinoma middle cerebral artery infarction pneumonia carcinoma non-small cell lung carcinoma Gaucher disease invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous carcinoma juvenile idiopathic arthritis pilocytic astrocytoma adenoma malignant colon neoplasm progressive supranuclear palsy psoriasis mammary neoplasms, animal common variable immunodeficiency Duchenne muscular dystrophy myopathy Emery-Dreifuss muscular dystrophy oligodendroglioma glioblastoma ovarian neoplasm ischemia reperfusion injury pancreatic intraductal papillary-mucinous neoplasm large cell medulloblastoma plasma cell myeloma lung cancer pneumonitis malignant ependymoma astrocytic tumor MALT lymphoma Castleman disease colorectal carcinoma temporal arteritis coronary artery disease dermatomyositis ulcerative colitis ductal breast carcinoma in situ neuromyelitis optica osteosarcoma pancreatic ductal adenocarcinoma juvenile dermatomyositis Pick disease lung carcinoma polycystic ovary syndrome malignant glioma cleft lip medulloblastoma spina bifida thrombocytopenia Crohn disease Down syndrome myocardial ischemia undifferentiated carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.