Download MendeleyActivation of DNMT1 by Chemically Synthesized Dual monoubiquitinated PAF15 Protein
Hayashi, G., Takahashi, Y., Kikuchi, A., Kori, S., Arita, K., Murakami, H.To be published.
8XQC | pdb_00008xqc
Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated PAF15 and hemimethylated DNA analog
- PDB DOI: https://doi.org/10.2210/pdb8XQC/pdb
- EM Map EMD-38573: EMDB EMDataResource
- NAKB: 8XQC
- Classification: TRANSFERASE
- Organism(s): Homo sapiens, synthetic construct
- Expression System: Spodoptera frugiperda
- Mutation(s): No
- Deposited: 2024-01-05 Released: 2025-01-15
- Funding Organization(s): Japan Society for the Promotion of Science (JSPS)
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 3.25 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| DNA (cytosine-5)-methyltransferase 1 | 1,271 | Homo sapiens | Mutation(s): 0 Gene Names: DNMT1, AIM, CXXC9, DNMT EC: 2.1.1.37 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P26358 (Homo sapiens) Explore P26358 Go to UniProtKB: P26358 | |||||
PHAROS: P26358 GTEx: ENSG00000130816 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P26358 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| SAH (Subject of Investigation/LOI) Query on SAH | D [auth A] | S-ADENOSYL-L-HOMOCYSTEINE C14 H20 N6 O5 S ZJUKTBDSGOFHSH-WFMPWKQPSA-N |  | ||
| ZN (Subject of Investigation/LOI) Query on ZN | E [auth A], F [auth A] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 3.25 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
Entry History & Funding Information
Deposition Data
- Released Date: 2025-01-15 Deposition Author(s): Kikuchi, A., Hayashi, G., Kori, S., Arita, K.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Japan Society for the Promotion of Science (JSPS) | Japan | 18H02392, 19H05294, 19H05741,19J22030 |
Revision History (Full details and data files)
- Version 1.0: 2025-01-15
Type: Initial release
