2B9Z | pdb_00002b9z

The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition.

(2005) EMBO Rep 6: 1149-1155

• PubMed: 16270100 Search on PubMedSearch on PubMed Central
• DOI: https://doi.org/10.1038/sj.embor.7400583
• Primary Citation of Related Structures:  
  2B9Z


• PubMed Abstract: 
  

  We report the structure of the flock house virus B2 protein, a potent suppressor of RNA interference (RNAi) in animals and plants. The B2 protein is a homodimer in solution and contains three alpha-helices per monomer. Chemical shift perturbation shows that an antiparallel arrangement of helices (alpha2/alpha2') forms an elongated binding interface with double-stranded RNA (dsRNA). This implies a novel mode of dsRNA recognition and provides insights into the mechanism of RNAi suppression by B2.

   View More

---

Organizational Affiliation: 

European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.