Download MendeleyUnexpected Binding Mode of a Bis-Phenylamidine Factor Xa Inhibitor Complexed to Bovine Trypsin
Alexander, R., Maduskuie, T., Mcnamara, K., Smallwood, A., Wei, A., Stouten, P.To be published.
1AZ8 | pdb_00001az8
BOVINE TRYPSIN COMPLEXED TO BIS-PHENYLAMIDINE INHIBITOR
- PDB DOI: https://doi.org/10.2210/pdb1AZ8/pdb
- Classification: SERINE PROTEASE
- Organism(s): Bos taurus
- Mutation(s): No
- Deposited: 1997-11-26 Released: 1999-01-13
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Work: 0.188 (Depositor)
- R-Value Observed: 0.188 (Depositor)
wwPDB Validation 3D Report Full Report
This is version 1.4 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| TRYPSIN | 223 | Bos taurus | Mutation(s): 0 EC: 3.4.21.4 |  | |
UniProt | |||||
Find proteins for P00760 (Bos taurus) Explore P00760 Go to UniProtKB: P00760 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P00760 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| IN4 Query on IN4 | B [auth A] | +/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATE C20 H24 N4 O2 PVALLOSAENRPQO-INIZCTEOSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Work: 0.188 (Depositor)
- R-Value Observed: 0.188 (Depositor)
Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 54.8 | α = 90 |
| b = 58.7 | β = 90 |
| c = 67.5 | γ = 90 |
| Software Name | Purpose |
|---|---|
| R-AXIS | data collection |
| R-AXIS | data reduction |
| X-PLOR | model building |
| X-PLOR | refinement |
| R-AXIS | data scaling |
| X-PLOR | phasing |
Entry History
Deposition Data
- Released Date: 1999-01-13 Deposition Author(s): Alexander, R., Smallwood, A.
Revision History (Full details and data files)
- Version 1.0: 1999-01-13
Type: Initial release - Version 1.1: 2008-03-24
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Version format compliance - Version 1.3: 2024-06-05
Changes: Data collection, Database references, Derived calculations, Other - Version 1.4: 2024-10-23
Changes: Structure summary
