7LZ6

The Cryo-EM structure of a complex between GAD65 and b96.11 Fab

Experimental Data Snapshot

  • Method: ELECTRON MICROSCOPY
  • Resolution: 7.30 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

wwPDB Validation   3D Report Full Report


This is version 1.1 of the entry. See complete history. 


Literature

Structure and dynamics of the autoantigen GAD65 in complex with the human autoimmune polyendocrine syndrome type 2-associated autoantibody b96.11

Stander, S.H.D., Reboul, C.F., Le, S.N., Williams, D.E., Chandler, P.G., Costa, M.G.S., Hoke, D.E., Jimma, J.D.T., Fodor, J., Fenalti, G., Mannering, S.I., Porebski, B.T., Schofield, P., Christ, D., Buckle, M., McGowan, S., Elmlund, D., Rand, K.D., Buckle, A.M.

(2024) bioRxiv 


Macromolecules
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Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
Glutamate decarboxylase 2
A, B
497Homo sapiensMutation(s): 0 
Gene Names: GAD2, GAD65
EC: 4.1.1.15
UniProt & NIH Common Fund Data Resources
Find proteins for Q05329 (Homo sapiens)
Explore Q05329 
Go to UniProtKB:  Q05329
PHAROS:  Q05329
GTEx:  ENSG00000136750 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupQ05329
Sequence Annotations
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  • Reference Sequence
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Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
b96.11 Fab heavy chain
C, E
228Homo sapiensMutation(s): 0 
Entity Groups  
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Sequence Annotations
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  • Reference Sequence
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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
b96.11 Fab light chain
D, F
217Homo sapiensMutation(s): 0 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: ELECTRON MICROSCOPY
  • Resolution: 7.30 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

Structure Validation

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View more in-depth experimental data
Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2024-10-30
    Type: Initial release
  • Version 1.1: 2024-11-13
    Changes: Data collection