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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Keywords HAS EXACT PHRASE "LYASE"

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Search Summary

This query matches 7,346 Structures.

Refinements

Structure Determination Methodology

experimental (7,346)

Scientific Name of Source Organism

	Homo sapiens (1,812)
	Escherichia coli (341)
	Escherichia coli K-12 (175)
	synthetic construct (149)
	Salmonella enterica subsp. enterica serovar Typhimurium (144)
	Mycobacterium tuberculosis (109)
	Arabidopsis thaliana (91)
	Mycobacterium tuberculosis H37Rv (89)
	Pseudomonas putida (89)
	Rattus norvegicus (86)

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Taxonomy

	Bacteria (3,903)
	Eukaryota (3,033)
	Archaea (345)
	other sequences (149)
	Duplodnaviria (13)
	Eukaryota (eukaryotes) (10)
	unclassified sequences (9)
	Varidnaviria (7)
	unclassified bacterial viruses (5)
	Viruses incertae sedis (2)

More...

Experimental Method

	X-RAY DIFFRACTION (7,224)
	ELECTRON MICROSCOPY (102)
	NEUTRON DIFFRACTION (16)
	SOLUTION NMR (12)
	ELECTRON CRYSTALLOGRAPHY (2)
	SOLUTION SCATTERING (1)

Polymer Entity Type

	Protein (7,346)
	DNA (197)
	RNA (8)
	NA-hybrid (3)

Refinement Resolution (Å)

	0.5 - 1.0 (47)
	1.0 - 1.5 (1,100)
	1.5 - 2.0 (2,768)
	2.0 - 2.5 (2,237)
	2.5 - 3.0 (939)
	3.0 - 3.5 (199)
	3.5 - 4.0 (30)
	4.0 - 4.5 (12)
	> 4.5 (8)

Release Date

	1975 - 1979 (1)
	1980 - 1984 (5)
	1990 - 1994 (105)
	1995 - 1999 (206)
	2000 - 2004 (764)
	2005 - 2009 (1,304)
	2010 - 2014 (1,686)
	2015 - 2019 (1,642)
	2020 - 2024 (1,578)
	2025 - 2029 (55)

Enzyme Classification Name

	Lyases (6,303)
	Transferases (546)
	Hydrolases (239)
	Isomerases (203)
	Oxidoreductases (88)
	Ligases (27)
	Translocases (1)

Membrane Protein Annotation

	OPM (18)
	PDBTM (21)
	mpstruc (15)
	MemProtMD (18)

Symmetry Type

	Asymmetric (3,045)
	Cyclic (2,832)
	Dihedral (1,692)
	Tetrahedral (89)
	Octahedral (35)
	Helical (2)
	Icosahedral (1)

SCOP Classification

	Alpha and beta proteins (a/b) (2,298)
	Alpha and beta proteins (a+b) (841)
	All beta proteins (1,357)
	All alpha proteins (534)
	Artifacts (512)
	Multi-domain proteins (alpha and beta) (37)
	Membrane and cell surface proteins and peptides (4)
	Small proteins (9)
	Low resolution protein structures (1)

AllSelected

1 to 25 of 7,346 Structures

Page 1 of 294

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4GYP \| pdb_00004gyp	Download File View File

Crystal structure of the heterotetrameric complex of GlucD and GlucDRP from E. coli K-12 MG1655 (EFI TARGET EFI-506058)

Lukk, T., Ghasempur, S., Imker, H.J., Gerlt, J.A., Nair, S.K., Enzyme Function Initiative (EFI)

To be published

Released	2012-09-12
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Escherichia coli K-12
Macromolecule	Glucarate dehydratase (protein) Glucarate dehydratase-related protein (protein)
Unique Ligands	CIT, GOL, MG, P6G, PEG, SO4

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1A42 \| pdb_00001a42	Download File View File

HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE

Boriack-Sjodin, P.A., Christianson, D.W.

(1998) Protein Sci 7: 556-563

Released	1999-03-23
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	CARBONIC ANHYDRASE II (protein)
Unique Ligands	BZU, HG, ZN

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1A50 \| pdb_00001a50	Download File View File

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE

Schneider, T.R., Gerhardt, E., Lee, M., Liang, P.-H., Anderson, K.S., Schlichting, I.

(1998) Biochemistry 37: 5394-5406

Released	1999-03-30
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Salmonella enterica subsp. enterica serovar Typhimurium
Macromolecule	TRYPTOPHAN SYNTHASE (ALPHA CHAIN) (protein) TRYPTOPHAN SYNTHASE (BETA CHAIN) (protein)
Unique Ligands	FIP, NA, PLP

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1A5A \| pdb_00001a5a	Download File View File

CRYO-CRYSTALLOGRAPHY OF A TRUE SUBSTRATE, INDOLE-3-GLYCEROL PHOSPHATE, BOUND TO A MUTANT (ALPHAD60N) TRYPTOPHAN SYNTHASE ALPHA2BETA2 COMPLEX REVEALS THE CORRECT ORIENTATION OF ACTIVE SITE ALPHA GLU 49

Rhee, S., Miles, E.W., Davies, D.R.

(1998) J Biological Chem 273: 8553-8555

Released	1998-05-27
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Salmonella enterica subsp. enterica serovar Typhimurium
Macromolecule	TRYPTOPHAN SYNTHASE (ALPHA CHAIN) (protein) TRYPTOPHAN SYNTHASE (BETA CHAIN) (protein)
Unique Ligands	K, PLP

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1A5B \| pdb_00001a5b	Download File View File

CRYO-CRYSTALLOGRAPHY OF A TRUE SUBSTRATE, INDOLE-3-GLYCEROL PHOSPHATE, BOUND TO A MUTANT (ALPHA D60N) TRYPTOPHAN SYNTHASE ALPHA2BETA2 COMPLEX REVEALS THE CORRECT ORIENTATION OF ACTIVE SITE ALPHA GLU 49

Rhee, S., Miles, E.W., Davies, D.R.

(1998) J Biological Chem 273: 8553-8555

Released	1998-05-27
Method	X-RAY DIFFRACTION 2 Å
Organisms	Salmonella enterica subsp. enterica serovar Typhimurium
Macromolecule	TRYPTOPHAN SYNTHASE (ALPHA CHAIN) (protein) TRYPTOPHAN SYNTHASE (BETA CHAIN) (protein)
Unique Ligands	IGP, K, PLP

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1A5C \| pdb_00001a5c	Download File View File

FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE FROM PLASMODIUM FALCIPARUM

Kim, H., Certa, U., Dobeli, H., Jakob, P., Hol, W.G.J.

(1998) Biochemistry 37: 4388-4396

Released	1998-06-10
Method	X-RAY DIFFRACTION 3 Å
Organisms	Plasmodium falciparum
Macromolecule	FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE (protein)

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1AB8 \| pdb_00001ab8	Download File View File

RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX

Zhang, G., Hurley, J.H.

(1997) Nature 386: 247-253

Released	1997-05-15
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Rattus norvegicus
Macromolecule	ADENYLYL CYCLASE (protein)
Unique Ligands	FOK

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1ADO \| pdb_00001ado	Download File View File

FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE FROM RABBIT MUSCLE

Blom, N.S., Sygusch, J.

(1997) Nat Struct Biol 4: 36-39

Released	1997-12-24
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Oryctolagus cuniculus
Macromolecule	ALDOLASE (protein)
Unique Ligands	13P, SO4

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1AHJ \| pdb_00001ahj	Download File View File

NITRILE HYDRATASE

Huang, W., Schneider, G., Lindqvist, Y.

(1997) Structure 5: 691-699

Released	1998-04-08
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Rhodococcus sp. R312
Macromolecule	NITRILE HYDRATASE (SUBUNIT ALPHA) (protein) NITRILE HYDRATASE (SUBUNIT BETA) (protein)
Unique Ligands	FE

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1AJ8 \| pdb_00001aj8	Download File View File

CITRATE SYNTHASE FROM PYROCOCCUS FURIOSUS

Russell, R.J.M., Ferguson, J.M.C., Hough, D.W., Danson, M.J., Taylor, G.L.

(1997) Biochemistry 36: 9983-9994

Released	1997-11-19
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Pyrococcus furiosus
Macromolecule	CITRATE SYNTHASE (protein)
Unique Ligands	CIT, COA

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1AL6 \| pdb_00001al6	Download File View File

CHICKEN CITRATE SYNTHASE COMPLEX WITH N-HYDROXYAMIDO-COA AND OXALOACETATE

Usher, K.C., Remington, S.J.

To be published

Released	1997-12-24
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Gallus gallus
Macromolecule	CITRATE SYNTHASE (protein)
Unique Ligands	HAX, OAA

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1AOS \| pdb_00001aos	Download File View File

HUMAN ARGININOSUCCINATE LYASE

Turner, M.A., Simpson, A., Mcinnes, R.R., Howell, P.L.

(1997) Proc Natl Acad Sci U S A 94: 9063-9068

Released	1998-01-14
Method	X-RAY DIFFRACTION 4.2 Å
Organisms	Homo sapiens
Macromolecule	ARGININOSUCCINATE LYASE (protein)

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1AVN \| pdb_00001avn	Download File View File

HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR

Briganti, F., Mangani, S., Orioli, P., Scozzafava, A., Vernaglione, G., Supuran, C.T.

(1997) Biochemistry 36: 10384-10392

Released	1997-12-24
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	CARBONIC ANHYDRASE II (protein)
Unique Ligands	AZI, HG, HSM, ZN

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1B0J \| pdb_00001b0j	Download File View File

CRYSTAL STRUCTURE OF ACONITASE WITH ISOCITRATE

Lloyd, S.J., Lauble, H., Prasad, G.S., Stout, C.D.

(1999) Protein Sci 8: 2655-2662

Released	1998-11-18
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Sus scrofa
Macromolecule	ACONITATE HYDRATASE (protein)
Unique Ligands	ICT, SF4

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1B0K \| pdb_00001b0k	Download File View File

S642A:FLUOROCITRATE COMPLEX OF ACONITASE

Lloyd, S.J., Lauble, H., Prasad, G.S., Stout, C.D.

(1999) Protein Sci 8: 2655-2662

Released	1999-11-18
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Sus scrofa
Macromolecule	PROTEIN (ACONITASE) (protein)
Unique Ligands	FLC, O, SF4

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1B4E \| pdb_00001b4e	Download File View File

X-ray structure of 5-aminolevulinic acid dehydratase complexed with the inhibitor levulinic acid

Erskine, P.T., Cooper, J.B., Lewis, G., Spencer, P., Wood, S.P., Shoolingin-Jordan, P.M.

(1999) Biochemistry 38: 4266-4276

Released	1999-12-17
Method	X-RAY DIFFRACTION 2 Å
Organisms	Escherichia coli
Macromolecule	PROTEIN (5-AMINOLEVULINIC ACID DEHYDRATASE) (protein)
Unique Ligands	GOL, SHF, SO4, ZN

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1B4K \| pdb_00001b4k	Download File View File

High resolution crystal structure of a MG2-dependent 5-aminolevulinic acid dehydratase

Frankenberg, N., Jahn, D., Heinz, D.W.

(1999) J Mol Biology 289: 591-602

Released	1999-07-13
Method	X-RAY DIFFRACTION 1.67 Å
Organisms	Pseudomonas aeruginosa PAO1
Macromolecule	PROTEIN (5-AMINOLEVULINIC ACID DEHYDRATASE) (protein)
Unique Ligands	MG, SHF, SO4

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1B57 \| pdb_00001b57	Download File View File

CLASS II FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE IN COMPLEX WITH PHOSPHOGLYCOLOHYDROXAMATE

Hall, D.R., Hunter, W.N.

(1999) J Mol Biology 287: 383-394

Released	2000-01-07
Method	X-RAY DIFFRACTION 2 Å
Organisms	Escherichia coli
Macromolecule	PROTEIN (FRUCTOSE-BISPHOSPHATE ALDOLASE II) (protein)
Unique Ligands	CL, NA, PGH, ZN

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1B6R \| pdb_00001b6r	Download File View File

N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE FROM E. COLI

Thoden, J.B., Kappock, T.J., Stubbe, J., Holden, H.M.

(1999) Biochemistry 38: 15480-15492

Released	1999-11-30
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Escherichia coli
Macromolecule	PROTEIN (N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE) (protein)
Unique Ligands	SO4

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1B6S \| pdb_00001b6s	Download File View File

STRUCTURE OF N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE

Thoden, J.B., Kappock, T.J., Stubbe, J., Holden, H.M.

(1999) Biochemistry 38: 15480-15492

Released	1999-11-30
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Escherichia coli
Macromolecule	PROTEIN (N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE) (protein)
Unique Ligands	ADP, MG

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1B6Z \| pdb_00001b6z	Download File View File

6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE

Ploom, T., Thoeny, B., Yim, J., Lee, S., Nar, H., Leimbacher, W., Huber, R., Richardson, J., Auerbach, G.

(1999) J Mol Biology 286: 851-860

Released	2000-01-21
Method	X-RAY DIFFRACTION 2 Å
Organisms	Rattus norvegicus
Macromolecule	6-pyruvoyl tetrahydropterin synthase (protein)
Unique Ligands	ZN

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1B8F \| pdb_00001b8f	Download File View File

Histidine ammonia-lyase (HAL) from Pseudomonas putida

Schwede, T.F., Schulz, G.E.

(1999) Biochemistry 38: 5355-5361

Released	1999-05-06
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Pseudomonas putida
Macromolecule	Histidine ammonia-lyase (protein)
Unique Ligands	GOL, SO4

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1B8G \| pdb_00001b8g	Download File View File

1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE

Capitani, G., Hohenester, E., Feng, L., Storici, P., Kirsch, J.F., Jansonius, J.N.

(1999) J Mol Biology 294: 745-756

Released	2000-01-26
Method	X-RAY DIFFRACTION 2.37 Å
Organisms	Malus domestica
Macromolecule	PROTEIN (1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE) (protein)
Unique Ligands	PLP

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1B93 \| pdb_00001b93	Download File View File

METHYLGLYOXAL SYNTHASE FROM ESCHERICHIA COLI

Saadat, D., Harrison, D.H.T.

(1999) Structure 7: 309-317

Released	1999-03-16
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Escherichia coli
Macromolecule	PROTEIN (METHYLGLYOXAL SYNTHASE) (protein)
Unique Ligands	FMT, PO4

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1BFD \| pdb_00001bfd	Download File View File

BENZOYLFORMATE DECARBOXYLASE FROM PSEUDOMONAS PUTIDA

Hasson, M.S., Muscate, A., Mcleish, M.J., Polovnikova, L.S., Gerlt, J.A., Kenyon, G.L., Petsko, G.A., Ringe, D.

(1998) Biochemistry 37: 9918-9930

Released	1998-06-24
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Pseudomonas putida
Macromolecule	BENZOYLFORMATE DECARBOXYLASE (protein)
Unique Ligands	CA, MG, TPP

1 to 25 of 7,346 Structures

Page 1 of 294

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

4GYP | pdb_00004gyp

1A42 | pdb_00001a42

1A50 | pdb_00001a50

1A5A | pdb_00001a5a

1A5B | pdb_00001a5b

1A5C | pdb_00001a5c

1AB8 | pdb_00001ab8

1ADO | pdb_00001ado

1AHJ | pdb_00001ahj

1AJ8 | pdb_00001aj8

1AL6 | pdb_00001al6

1AOS | pdb_00001aos

1AVN | pdb_00001avn

1B0J | pdb_00001b0j

1B0K | pdb_00001b0k

1B4E | pdb_00001b4e

1B4K | pdb_00001b4k

1B57 | pdb_00001b57

1B6R | pdb_00001b6r

1B6S | pdb_00001b6s

1B6Z | pdb_00001b6z

1B8F | pdb_00001b8f

1B8G | pdb_00001b8g

1B93 | pdb_00001b93

1BFD | pdb_00001bfd