RCSB PDB: Search

2VC2	Download File View File

Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist L-739758

(2008) J Cell Biol 182: 791

Released	2008-09-02
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	INTEGRIN ALPHA-IIB (protein) INTEGRIN BETA-3 (protein) MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN (protein) MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN (protein)
Unique Ligands	180, CA, GOL, MG, NAG
Unique branched monosaccharides	MAN, NAG

2VDK	Download File View File

Re-refinement of Integrin AlphaIIbBeta3 Headpiece

(2008) J Cell Biol 182: 791

Released	2008-09-02
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	INTEGRIN ALPHA-IIB (protein) INTEGRIN BETA-3 (protein) MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN (protein) MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN (protein)
Unique Ligands	CA, CAC, GOL, MG, NAG
Unique branched monosaccharides	MAN, NAG

2VDL	Download File View File

Re-refinement of Integrin AlphaIIbBeta3 Headpiece

(2008) J Cell Biol 182: 791

Released	2008-09-02
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	INTEGRIN ALPHA-IIB (protein) INTEGRIN BETA-3 (protein) MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN (protein) MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN (protein)
Unique Ligands	CA, CAC, GOL, MG, NAG
Unique branched monosaccharides	MAN, NAG

2VDM	Download File View File

Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Tirofiban

(2008) J Cell Biol 182: 791

Released	2008-09-02
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	INTEGRIN ALPHA-IIB (protein) INTEGRIN BETA-3 (protein) MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN (protein) MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN (protein)
Unique Ligands	AGG, CA, GOL, MG, NAG
Unique branched monosaccharides	MAN, NAG

2VDN	Download File View File

Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Eptifibatide

(2008) J Cell Biol 182: 791

Released	2008-09-02
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens Mus musculus synthetic construct
Macromolecule	EPTIFIBATIDE (protein) INTEGRIN ALPHA-IIB (protein) INTEGRIN BETA-3 (protein) MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN (protein) MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN (protein)
Unique Ligands	CA, GOL, MG, NAG
Unique branched monosaccharides	MAN, NAG

2VDO	Download File View File

Integrin AlphaIIbBeta3 Headpiece Bound to Fibrinogen Gamma chain peptide, HHLGGAKQAGDV

(2008) J Cell Biol 182: 791

Released	2008-09-02
Method	X-RAY DIFFRACTION 2.51 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	FIBRINOGEN, GAMMA POLYPEPTIDE (protein) INTEGRIN ALPHA-IIB (protein) INTEGRIN BETA-3 (protein) MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN (protein) MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN (protein)
Unique Ligands	CA, GOL, MG, NAG
Unique branched monosaccharides	MAN, NAG

2VDP	Download File View File

Integrin AlphaIIbBeta3 Headpiece Bound to Fibrinogen Gamma chain peptide,LGGAKQAGDV

(2008) J Cell Biol 182: 791

Released	2008-09-02
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	FIBRINOGEN (protein) INTEGRIN ALPHA-IIB (protein) INTEGRIN BETA-3 (protein) MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN (protein) MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN (protein)
Unique Ligands	CA, GOL, MG, NAG
Unique branched monosaccharides	MAN, NAG

2VDQ	Download File View File

Integrin AlphaIIbBeta3 Headpiece Bound to a Chimeric Fibrinogen Gamma chain peptide, HHLGGAKQRGDV

(2008) J Cell Biol 182: 791

Released	2008-09-02
Method	X-RAY DIFFRACTION 2.59 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	FIBRINOGEN, GAMMA POLYPEPTIDE (protein) INTEGRIN ALPHA-IIB (protein) INTEGRIN BETA-3 (protein) MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN (protein) MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN (protein)
Unique Ligands	CA, GOL, MG, NAG
Unique branched monosaccharides	MAN, NAG

2VDR	Download File View File

Integrin AlphaIIbBeta3 Headpiece Bound to a chimeric Fibrinogen Gamma chain peptide, LGGAKQRGDV

(2008) J Cell Biol 182: 791

Released	2008-09-02
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	FIBRINOGEN (protein) INTEGRIN ALPHA-IIB (protein) INTEGRIN BETA-3 (protein) MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN (protein) MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN (protein)
Unique Ligands	CA, GOL, MG, NAG
Unique branched monosaccharides	MAN, NAG

3BN3	Download File View File

crystal structure of ICAM-5 in complex with aL I domain

Zhang, H., Springer, T.A., Wang, J.-h.

(2008) Mol Cell 31: 432-437

Released	2008-08-19
Method	X-RAY DIFFRACTION 2.099 Å
Organisms	Homo sapiens
Macromolecule	Integrin alpha-L (protein) Intercellular adhesion molecule 5 (protein)
Unique Ligands	GOL, MG, NAG
Unique branched monosaccharides	NAG

3FF7	Download File View File

Structure of NK cell receptor KLRG1 bound to E-cadherin

Li, Y., Mariuzza, R.A.

(2009) Immunity 31: 35-46

Released	2009-07-28
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Epithelial cadherin (protein) Killer cell lectin-like receptor subfamily G member 1 (protein)
Unique Ligands	ACY

3FF8	Download File View File

Structure of NK cell receptor KLRG1 bound to E-cadherin

Li, Y., Mariuzza, R.A.

(2009) Immunity 31: 35-46

Released	2009-07-28
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Epithelial cadherin (protein) Killer cell lectin-like receptor subfamily G member 1 (protein)
Unique Ligands	CA

3HI6	Download File View File

Crystal structure of intermediate affinity I domain of integrin LFA-1 with the Fab fragment of its antibody AL-57

Zhang, H., Wang, J.

(2009) Proc Natl Acad Sci U S A 106: 18345-18350

Released	2009-09-22
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Heavy chain of Fab fragment of AL-57 against alpha L I domain (protein) Integrin alpha-L (protein) light chain of Fab fragment of AL-57 against alpha L I domain (protein)
Unique Ligands	MN, SO4

3O8E	Download File View File

Structure of extracelllar portion of CD46 in complex with Adenovirus type 11 knob

Persson, B.D., Schmitz, N.B., Casasnovas, J.M., Stehle, T.

(2010) PLoS Pathog 6: e1001122-e1001122

Released	2010-10-13
Method	X-RAY DIFFRACTION 2.84 Å
Organisms	Homo sapiens Human adenovirus 11
Macromolecule	Fiber 36.1 kDa protein (protein) Membrane cofactor protein (protein)
Unique Ligands	DTD
Unique branched monosaccharides	NAG

3VI3	Download File View File

Crystal structure of alpha5beta1 integrin headpiece (ligand-free form)

Nagae, M., Nogi, T., Takagi, J.

(2012) J Cell Biol 197: 131-140

Released	2012-02-22
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Integrin alpha-5 (protein) Integrin beta-1 (protein) SG/19 Fab fragment (Heavy chain) (protein) SG/19 Fab fragment (Light chain) (protein)
Unique Ligands	CA, MG, NAG
Unique branched monosaccharides	BMA, MAN, NAG

3VI4	Download File View File

Crystal structure of alpha5beta1 integrin headpiece in complex with RGD peptide

Nagae, M., Nogi, T., Takagi, J.

(2012) J Cell Biol 197: 131-140

Released	2012-02-22
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Integrin alpha-5 (protein) Integrin beta-1 (protein) RGD peptide (protein) SG/19 Fab fragment (Heavy chain) (protein) SG/19 Fab fragment (Light chain) (protein)
Unique Ligands	CA, MG, NAG
Unique branched monosaccharides	BMA, MAN, NAG

3ZDX	Download File View File

Integrin alphaIIB beta3 headpiece and RGD peptide complex

Zhu, J.H., Zhu, J.Q., Springer, T.A.

(2013) J Cell Biol 201: 1053

Released	2013-06-05
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	10E5 FAB, HEAVY CHAIN (protein) 10E5 FAB, LIGHT CHAIN (protein) INTEGRIN ALPHA-IIB (protein) INTEGRIN BETA-3 (protein)
Unique Ligands	CA, CL, GOL, MN, NAG, SO4
Unique branched monosaccharides	BMA, MAN, NAG

4LMQ	Download File View File

Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12

Zhong, Z., Wang, J., Li, B., Xiang, H., Ultsch, M., Coons, M., Wong, T., Chiang, N.Y., Clark, S., Clark, R., Quintana, L., Gribling, P., Suto, E., Barck, K., Corpuz, R., Yao, J., Takkar, R., Lee, W.P., Damico-Beyer, L.A., Carano, R.D., Adams, C., Kelley, R.F., Wang, W., Ferrara, N.

(2013) Clin Cancer Res 19: 4433-4445

Released	2013-08-14
Method	X-RAY DIFFRACTION 2.773 Å
Organisms	Homo sapiens
Macromolecule	Stromal cell-derived factor 1 (protein) hu30D8 Fab heavy chain (protein) hu30D8 Fab light chain (protein)

4WJK	Download File View File

Metal Ion and Ligand Binding of Integrin

(2014) Proc Natl Acad Sci U S A 111: 17863-17868

Released	2014-12-03
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Integrin alpha-5 (protein) Integrin beta-1 (protein)
Unique Ligands	CA, MG, NAG
Unique branched monosaccharides	BMA, MAN, NAG

4WK0	Download File View File

Metal Ion and Ligand Binding of Integrin

(2014) Proc Natl Acad Sci U S A 111: 17863-17868

Released	2014-12-03
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Homo sapiens
Macromolecule	ARG-GLY-ASP (protein) Integrin alpha-5 (protein) Integrin beta-1 (protein)
Unique Ligands	CA, MG, NAG
Unique branched monosaccharides	BMA, MAN, NAG

4WK2	Download File View File

Metal Ion and Ligand Binding of Integrin

(2014) Proc Natl Acad Sci U S A 111: 17863-17868

Released	2014-12-03
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	GLY-ARG-GLY-ASP-SER-PRO (protein) Integrin alpha-5 (protein) Integrin beta-1 (protein)
Unique Ligands	CA, MG, NAG
Unique branched monosaccharides	BMA, MAN, NAG

4WK4	Download File View File

Metal Ion and Ligand Binding of Integrin

(2014) Proc Natl Acad Sci U S A 111: 17863-17868

Released	2014-12-03
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	ALA-CYS-ARG-GLY-ASP-GLY-TRP-CYS (protein) Integrin alpha-5 (protein) Integrin beta-1 (protein)
Unique Ligands	CA, MG, NAG
Unique branched monosaccharides	BMA, MAN, NAG

5JYL	Download File View File

Human P-cadherin MEC1 with scFv TSP7 bound

Caaveiro, J.M.M., Kudo, S., Tsumoto, K.

(2017) Sci Rep 7: 39518-39518

Released	2016-12-28
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Cadherin-3 (protein) scFv TSP7 (protein)
Unique Ligands	CL, GOL, PO4

5JYM	Download File View File

Human P-cadherin EC12 with scFv TSP11 bound

Caaveiro, J.M.M., Kudo, S., Tsumoto, K.

(2017) Sci Rep 7: 39518-39518

Released	2016-12-28
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Antibody scFv TSP11 (protein) Cadherin-3 (protein)
Unique Ligands	CA