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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "SYNCRIP"

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Search Summary

This query matches 18 Structures.

Refinements

Structure Determination Methodology

experimental (18)

Scientific Name of Source Organism

Homo sapiens (18)

Taxonomy

Eukaryota (18)

Experimental Method

X-RAY DIFFRACTION (18)

Polymer Entity Type

Protein (18)

Refinement Resolution (Å)

	1.5 - 2.0 (4)
	2.0 - 2.5 (5)
	2.5 - 3.0 (6)
	3.0 - 3.5 (3)

Release Date

	2010 - 2014 (13)
	2015 - 2019 (3)
	2020 - 2024 (2)

Enzyme Classification Name

Transferases (18)

Symmetry Type

	Asymmetric (18)
	Cyclic (4)

SCOP Classification

	Alpha and beta proteins (a+b) (15)
	All alpha proteins (1)
	Artifacts (1)

AllSelected

1 to 18 of 18 Structures

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Explore in 3D

3WE4 \| pdb_00003we4	Download File View File

Crystal structure of S6K1 kinase domain in complex with a pyrimidine derivative PF-4708671 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole

Niwa, H., Shirouzu, M., Yokoyama, S.

(2014) J Struct Funct Genomics 15: 153-164

Released	2014-08-06
Method	X-RAY DIFFRACTION 1.995 Å
Organisms	Homo sapiens
Macromolecule	Ribosomal protein S6 kinase beta-1 (protein)
Unique Ligands	5FI, ZN

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3WF5 \| pdb_00003wf5	Download File View File

Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative 4-[4-(1H-benzimidazol-2-yl)piperidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

Niwa, H., Shirouzu, M., Yokoyama, S.

(2014) J Struct Funct Genomics 15: 153-164

Released	2014-08-06
Method	X-RAY DIFFRACTION 2.099 Å
Organisms	Homo sapiens
Macromolecule	Ribosomal protein S6 kinase beta-1 (protein)
Unique Ligands	FZ8, ZN

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3WF6 \| pdb_00003wf6	Download File View File

Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative 4-[4-(1H-indol-3-yl)-3,6-dihydropyridin-1(2H)-yl]-1H-pyrazolo[3,4-d]pyrimidine

Niwa, H., Shirouzu, M., Yokoyama, S.

(2014) J Struct Funct Genomics 15: 153-164

Released	2014-08-06
Method	X-RAY DIFFRACTION 2.031 Å
Organisms	Homo sapiens
Macromolecule	Ribosomal protein S6 kinase beta-1 (protein)
Unique Ligands	FZ9, ZN

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3WF7 \| pdb_00003wf7	Download File View File

Crystal structure of S6K1 kinase domain in complex with a purine derivative 1-(9H-purin-6-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide

Niwa, H., Shirouzu, M., Yokoyama, S.

(2014) J Struct Funct Genomics 15: 153-164

Released	2014-08-06
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Ribosomal protein S6 kinase beta-1 (protein)
Unique Ligands	FS9, GOL, ZN

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3WF8 \| pdb_00003wf8	Download File View File

Crystal structure of S6K1 kinase domain in complex with a quinoline derivative 2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline-11-carboxylate

Niwa, H., Shirouzu, M., Yokoyama, S.

(2014) J Struct Funct Genomics 15: 153-164

Released	2014-08-06
Method	X-RAY DIFFRACTION 1.975 Å
Organisms	Homo sapiens
Macromolecule	Ribosomal protein S6 kinase beta-1 (protein)
Unique Ligands	F76, GOL, ZN

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3WF9 \| pdb_00003wf9	Download File View File

Crystal structure of S6K1 kinase domain in complex with a quinoline derivative 1-oxo-1-[(4-sulfamoylphenyl)amino]propan-2-yl-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylate

Niwa, H., Shirouzu, M., Yokoyama, S.

(2014) J Struct Funct Genomics 15: 153-164

Released	2014-08-06
Method	X-RAY DIFFRACTION 2.035 Å
Organisms	Homo sapiens
Macromolecule	Ribosomal protein S6 kinase beta-1 (protein)
Unique Ligands	FS7, GOL, ZN

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4L3J \| pdb_00004l3j	Download File View File

Crystal structures of human p70S6K1 kinase domain

Wang, J., Zhong, C., Ding, J.

(2013) Biochem J 454: 39-47

Released	2013-07-24
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	RPS6KB1 protein (protein)
Unique Ligands	5FI, ZN

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4L3L \| pdb_00004l3l	Download File View File

Crystal structures of human p70S6K1 kinase domain (Zinc anomalous)

Wang, J., Zhong, C., Ding, J.

(2013) Biochem J 454: 39-47

Released	2013-07-24
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	RPS6KB1 protein (protein)
Unique Ligands	5FI, ZN

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4L42 \| pdb_00004l42	Download File View File

Crystal structures of human p70S6K1-PIF

Wang, J., Zhong, C., Ding, J.

(2013) Biochem J 454: 39-47

Released	2013-07-24
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	RPS6KB1 protein (protein)
Unique Ligands	5FI, SO4, ZN

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4L43 \| pdb_00004l43	Download File View File

Crystal structures of human p70S6K1-T389A (form I)

Wang, J., Zhong, C., Ding, J.

(2013) Biochem J 454: 39-47

Released	2013-07-24
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	RPS6KB1 protein (protein)
Unique Ligands	5FI

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4L44 \| pdb_00004l44	Download File View File

Crystal structures of human p70S6K1-T389A (form II)

Wang, J., Zhong, C., Ding, J.

(2013) Biochem J 454: 39-47

Released	2013-07-24
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	RPS6KB1 protein (protein)
Unique Ligands	5FI, SO4, ZN

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4L45 \| pdb_00004l45	Download File View File

Crystal structures of human p70S6K1-T389E

Wang, J., Zhong, C., Ding, J.

(2013) Biochem J 454: 39-47

Released	2013-07-24
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	RPS6KB1 protein (protein)
Unique Ligands	5FI

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4L46 \| pdb_00004l46	Download File View File

Crystal structures of human p70S6K1-WT

Wang, J., Zhong, C., Ding, J.

(2013) Biochem J 454: 39-47

Released	2013-07-24
Method	X-RAY DIFFRACTION 3.01 Å
Organisms	Homo sapiens
Macromolecule	RPS6KB1 protein (protein)
Unique Ligands	5FI, SO4, ZN

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4RLO \| pdb_00004rlo	Download File View File

Human p70s6k1 with ruthenium-based inhibitor EM5

Domsic, J.F., Barber-Rotenberg, J., Salami, J., Qin, J., Marmorstein, R.

(2015) J Med Chem 58: 305-314

Released	2015-01-21
Method	X-RAY DIFFRACTION 2.527 Å
Organisms	Homo sapiens
Macromolecule	Ribosomal protein S6 kinase beta-1 (protein)
Unique Ligands	3T3, CL, DMS, GOL, SO4, STU

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4RLP \| pdb_00004rlp	Download File View File

Human p70s6k1 with ruthenium-based inhibitor FL772

Domsic, J.F., Barber-Rotenberg, J., Salami, J., Qin, J., Marmorstein, R.

(2015) J Med Chem 58: 305-314

Released	2015-01-21
Method	X-RAY DIFFRACTION 2.79 Å
Organisms	Homo sapiens
Macromolecule	p70S6K1 (protein)
Unique Ligands	72B, CL

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5WBH \| pdb_00005wbh	Download File View File

Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1

Pavletich, N.P., Yang, H.

(2017) Nature 552: 368-373

Released	2017-12-20
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Ribosomal protein S6 kinase beta-1 (protein) Serine/threonine-protein kinase mTOR (protein)

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7N91 \| pdb_00007n91	Download File View File

P70 S6K1 IN COMPLEX WITH MSC2317067A-1

Mochalkin, I.

(2021) J Med Chem 64: 14603-14619

Released	2022-07-06
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Ribosomal protein S6 kinase beta-1 (protein)
Unique Ligands	1RJ

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7N93 \| pdb_00007n93	Download File View File

P70 S6K1 IN COMPLEX WITH MSC2363318A-1

Mochalkin, I.

(2021) J Med Chem 64: 14603-14619

Released	2022-07-06
Method	X-RAY DIFFRACTION 2.74 Å
Organisms	Homo sapiens
Macromolecule	Ribosomal protein S6 kinase beta-1 (protein)
Unique Ligands	1SK

1 to 18 of 18 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

3WE4 | pdb_00003we4

Crystal structure of S6K1 kinase domain in complex with a pyrimidine derivative PF-4708671 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole

3WF5 | pdb_00003wf5

Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative 4-[4-(1H-benzimidazol-2-yl)piperidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

3WF6 | pdb_00003wf6

Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative 4-[4-(1H-indol-3-yl)-3,6-dihydropyridin-1(2H)-yl]-1H-pyrazolo[3,4-d]pyrimidine

3WF7 | pdb_00003wf7

Crystal structure of S6K1 kinase domain in complex with a purine derivative 1-(9H-purin-6-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide

3WF8 | pdb_00003wf8

Crystal structure of S6K1 kinase domain in complex with a quinoline derivative 2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline-11-carboxylate

3WF9 | pdb_00003wf9

Crystal structure of S6K1 kinase domain in complex with a quinoline derivative 1-oxo-1-[(4-sulfamoylphenyl)amino]propan-2-yl-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylate

4L3J | pdb_00004l3j

Crystal structures of human p70S6K1 kinase domain

4L3L | pdb_00004l3l

Crystal structures of human p70S6K1 kinase domain (Zinc anomalous)

4L42 | pdb_00004l42

Crystal structures of human p70S6K1-PIF

4L43 | pdb_00004l43

Crystal structures of human p70S6K1-T389A (form I)

4L44 | pdb_00004l44

Crystal structures of human p70S6K1-T389A (form II)

4L45 | pdb_00004l45

Crystal structures of human p70S6K1-T389E

4L46 | pdb_00004l46

Crystal structures of human p70S6K1-WT

4RLO | pdb_00004rlo

Human p70s6k1 with ruthenium-based inhibitor EM5

4RLP | pdb_00004rlp

Human p70s6k1 with ruthenium-based inhibitor FL772

5WBH | pdb_00005wbh

Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1

7N91 | pdb_00007n91

P70 S6K1 IN COMPLEX WITH MSC2317067A-1

7N93 | pdb_00007n93

P70 S6K1 IN COMPLEX WITH MSC2363318A-1

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

3WE4 | pdb_00003we4

3WF5 | pdb_00003wf5

3WF6 | pdb_00003wf6

3WF7 | pdb_00003wf7

3WF8 | pdb_00003wf8

3WF9 | pdb_00003wf9

4L3J | pdb_00004l3j

4L3L | pdb_00004l3l

4L42 | pdb_00004l42

4L43 | pdb_00004l43

4L44 | pdb_00004l44

4L45 | pdb_00004l45

4L46 | pdb_00004l46

4RLO | pdb_00004rlo

4RLP | pdb_00004rlp

5WBH | pdb_00005wbh

7N91 | pdb_00007n91

7N93 | pdb_00007n93