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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "SIN1"

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Search Summary

This query matches 16 Structures.

Refinements

Structure Determination Methodology

experimental (16)

Scientific Name of Source Organism

	Homo sapiens (14)
	Schizosaccharomyces pombe 972h- (2)

Taxonomy

Eukaryota (16)

Experimental Method

	ELECTRON MICROSCOPY (7)
	X-RAY DIFFRACTION (7)
	SOLUTION NMR (2)

Polymer Entity Type

Protein (16)

Refinement Resolution (Å)

	1.5 - 2.0 (4)
	2.0 - 2.5 (2)
	2.5 - 3.0 (1)
	3.0 - 3.5 (5)
	3.5 - 4.0 (1)
	> 4.5 (1)

Release Date

	2010 - 2014 (1)
	2015 - 2019 (3)
	2020 - 2024 (12)

Enzyme Classification Name

	Transferases (7)
	Hydrolases (6)

Symmetry Type

	Asymmetric (12)
	Cyclic (4)

SCOP Classification

	Alpha and beta proteins (a/b) (1)
	Artifacts (1)

AllSelected

1 to 16 of 16 Structures

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2RUJ \| pdb_00002ruj	Download File View File

Solution structure of MTSL spin-labeled Schizosaccharomyces pombe Sin1 CRIM domain

Furuita, K., Kataoka, S., Sugiki, T., Kobayashi, N., Ikegami, T., Shiozaki, K., Fujiwara, T., Kojima, C.

(2015) J Biomol NMR 61: 55-64

Released	2015-07-29
Method	SOLUTION NMR
Organisms	Schizosaccharomyces pombe 972h-
Macromolecule	Stress-activated map kinase-interacting protein 1 (protein)

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2RVK \| pdb_00002rvk	Download File View File

Refined solution structure of Schizosaccharomyces pombe Sin1 CRIM domain

Furuita, K., Kataoka, S., Shiozaki, K., Kojima, C.

(2017) Elife 6:

Released	2017-01-25
Method	SOLUTION NMR
Organisms	Schizosaccharomyces pombe 972h-
Macromolecule	Stress-activated map kinase-interacting protein 1 (protein)

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3VOQ \| pdb_00003voq	Download File View File

Crystal structure of the pleckstrin homology domain of human Sin1, a TORC2 subunit

Pan, D., Matsuura, Y.

(2012) Acta Crystallogr Sect F Struct Biol Cryst Commun 68: 386-392

Released	2012-04-11
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Target of rapamycin complex 2 subunit MAPKAP1 (protein)

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5ZCS \| pdb_00005zcs	Download File View File

4.9 Angstrom Cryo-EM structure of human mTOR complex 2

Chen, X., Liu, M., Tian, Y., Wang, H., Wang, J., Xu, Y.

(2018) Cell Res 28: 518-528

Released	2018-03-21
Method	ELECTRON MICROSCOPY 4.9 Å
Organisms	Homo sapiens
Macromolecule	Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)

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6ZWM \| pdb_00006zwm	Download File View File

cryo-EM structure of human mTOR complex 2, overall refinement

Scaiola, A., Mangia, F., Imseng, S., Boehringer, D., Ban, N., Maier, T.

(2020) Sci Adv 6:

Released	2020-11-18
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens
Macromolecule	Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	ACE, AGS, IHP, ZN

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6ZWO \| pdb_00006zwo	Download File View File

cryo-EM structure of human mTOR complex 2, focused on one half

Scaiola, A., Mangia, F., Imseng, S., Boehringer, D., Ban, N., Maier, T.

(2020) Sci Adv 6:

Released	2020-11-18
Method	ELECTRON MICROSCOPY 3 Å
Organisms	Homo sapiens
Macromolecule	Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	ACE, AGS, IHP, ZN

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7LC1 \| pdb_00007lc1	Download File View File

Crystal Structure of KRAS4b (GMPPNP-bound) in complex with the RBD-PH domains of SIN1

Dharmaiah, S., Simanshu, D.K.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-08-04
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Isoform 2B of GTPase KRas (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein)
Unique Ligands	GNP, MG

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7LC2 \| pdb_00007lc2	Download File View File

Crystal Structure of KRAS4b-Q61R (GMPPNP-bound) in complex with the RAS-binding domain (RBD) of SIN1

Dharmaiah, S., Simanshu, D.K.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-07-28
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein)
Unique Ligands	GNP, MG

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7PE7 \| pdb_00007pe7	Download File View File

cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement

Waelchli, M., Maier, T.

(2021) Elife 10:

Released	2021-09-15
Method	ELECTRON MICROSCOPY 3.41 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	ACE, IHP, ZN

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7PE8 \| pdb_00007pe8	Download File View File

cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer

Waelchli, M., Maier, T.

(2021) Elife 10:

Released	2021-09-08
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	ACE, IHP, ZN

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7PE9 \| pdb_00007pe9	Download File View File

cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement

Waelchli, M., Maier, T.

(2021) Elife 10:

Released	2021-09-08
Method	ELECTRON MICROSCOPY 3.7 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	ACE, IHP, ZN

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7TZO \| pdb_00007tzo	Download File View File

The apo structure of human mTORC2 complex

Yu, Z., Chen, J., Pearce, D.

(2022) J Biological Chem 298: 102288-102288

Released	2023-01-11
Method	ELECTRON MICROSCOPY 3.28 Å
Organisms	Homo sapiens
Macromolecule	Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)

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7VV8 \| pdb_00007vv8	Download File View File

Crystal Structure of HRasQ61L(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1

Zheng, Y.Y., Zhou, C.

(2022) Proc Natl Acad Sci U S A 119: e2119990119-e2119990119

Released	2022-05-18
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	GTPase HRas (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein)
Unique Ligands	GNP, MG

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7VV9 \| pdb_00007vv9	Download File View File

Crystal Structure of HRas(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1

Zheng, Y.Y., Zhou, C.

(2022) Proc Natl Acad Sci U S A 119: e2119990119-e2119990119

Released	2022-05-18
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	GTPase HRas (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein)
Unique Ligands	GNP, MG

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7VVB \| pdb_00007vvb	Download File View File

Crystal Structure of KRas4A(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1

Zheng, Y.Y., Zhou, C.

(2022) Proc Natl Acad Sci U S A 119: e2119990119-e2119990119

Released	2022-05-18
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein)
Unique Ligands	GNP, MG

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7VVG \| pdb_00007vvg	Download File View File

Crystal Structure of HRasG12V(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1

Zheng, Y.Y., Zhou, C.

(2022) Proc Natl Acad Sci U S A 119: e2119990119-e2119990119

Released	2022-05-18
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	GTPase HRas (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein)
Unique Ligands	GNP, MG

1 to 16 of 16 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

2RUJ | pdb_00002ruj

Solution structure of MTSL spin-labeled Schizosaccharomyces pombe Sin1 CRIM domain

2RVK | pdb_00002rvk

Refined solution structure of Schizosaccharomyces pombe Sin1 CRIM domain

3VOQ | pdb_00003voq

Crystal structure of the pleckstrin homology domain of human Sin1, a TORC2 subunit

5ZCS | pdb_00005zcs

4.9 Angstrom Cryo-EM structure of human mTOR complex 2

6ZWM | pdb_00006zwm

cryo-EM structure of human mTOR complex 2, overall refinement

6ZWO | pdb_00006zwo

cryo-EM structure of human mTOR complex 2, focused on one half

7LC1 | pdb_00007lc1

Crystal Structure of KRAS4b (GMPPNP-bound) in complex with the RBD-PH domains of SIN1

7LC2 | pdb_00007lc2

Crystal Structure of KRAS4b-Q61R (GMPPNP-bound) in complex with the RAS-binding domain (RBD) of SIN1

7PE7 | pdb_00007pe7

cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement

7PE8 | pdb_00007pe8

cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer

7PE9 | pdb_00007pe9

cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement

7TZO | pdb_00007tzo

The apo structure of human mTORC2 complex

7VV8 | pdb_00007vv8

Crystal Structure of HRasQ61L(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1

7VV9 | pdb_00007vv9

Crystal Structure of HRas(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1

7VVB | pdb_00007vvb

Crystal Structure of KRas4A(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1

7VVG | pdb_00007vvg

Crystal Structure of HRasG12V(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2RUJ | pdb_00002ruj

2RVK | pdb_00002rvk

3VOQ | pdb_00003voq

5ZCS | pdb_00005zcs

6ZWM | pdb_00006zwm

6ZWO | pdb_00006zwo

7LC1 | pdb_00007lc1

7LC2 | pdb_00007lc2

7PE7 | pdb_00007pe7

7PE8 | pdb_00007pe8

7PE9 | pdb_00007pe9

7TZO | pdb_00007tzo

7VV8 | pdb_00007vv8

7VV9 | pdb_00007vv9

7VVB | pdb_00007vvb

7VVG | pdb_00007vvg