RCSB PDB: Search

1X4R \| pdb_00001x4r	Download File View File

Solution structure of WWE domain in Parp14 protein

He, F., Muto, Y., Inoue, M., Kigawa, T., Shirouzu, M., Terada, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)

To be published

Released	2005-11-14
Method	SOLUTION NMR
Organisms	Mus musculus
Macromolecule	Parp14 protein (protein)

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3GOY \| pdb_00003goy	Download File View File

Crystal structure of human poly(adp-ribose) polymerase 14, catalytic fragment in complex with an inhibitor 3-aminobenzamide

Karlberg, T., Moche, M., Lehtio, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kotenyova, T., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Schutz, P., Siponen, M.I., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Schuler, H., Structural Genomics Consortium (SGC)

(2012) Nat Biotechnol 30: 283-288

Released	2009-04-14
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	3AB

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3Q6Z \| pdb_00003q6z	Download File View File

HUman PARP14 (ARTD8)-Macro domain 1 in complex with adenosine-5-diphosphoribose

Karlberg, T., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin, S., Flores, A., Graslund, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nordlund, P., Nyman, T., Persson, C., Sehic, A., Thorsell, A.G., Tresaugues, L., Wahlberg, E., Weigelt, J., Welin, M., Schuler, H., Structural Genomics Consortium (SGC)

(2013) Structure 21: 462-475

Released	2011-02-09
Method	X-RAY DIFFRACTION 2.23 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	APR

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3Q71 \| pdb_00003q71	Download File View File

Human parp14 (artd8) - macro domain 2 in complex with adenosine-5-diphosphoribose

Karlberg, T., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin, S., Flores, A., Graslund, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nordlund, P., Nyman, T., Persson, C., Sehic, A., Thorsell, A.G., Tresaugues, L., Wahlberg, E., Weigelt, J., Welin, M., Schuler, H., Structural Genomics Consortium (SGC)

(2013) Structure 21: 462-475

Released	2011-01-26
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	AR6

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3SE2 \| pdb_00003se2	Download File View File

Human poly(ADP-ribose) polymerase 14 (PARP14/ARTD8) - catalytic domain in complex with 6(5H)-phenanthridinone

Karlberg, T., Schutz, P., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Graslund, S., Kouznetsova, E., Moche, M., Nordlund, P., Nyman, T., Thorsell, A.G., Tresaugues, L., Weigelt, J., Siponen, M.I., Schuler, H., Structural Genomics Consortium (SGC)

(2012) Nat Biotechnol 30: 283-288

Released	2011-07-06
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	3AB, CL, GOL, LDR, SCN

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3SMI \| pdb_00003smi	Download File View File

Human poly(ADP-ribose) polymerase 14 (Parp14/Artd8) - catalytic domain in complex with a quinazoline inhibitor

Karlberg, T., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Edwards, A.M., Ekblad, T., Graslund, S., Kouznetsova, E., Nordlund, P., Nyman, T., Thorsell, A.G., Tresaugues, L., Weigelt, J., Schuler, H., Structural Genomics Consortium (SGC)

(2012) Nat Biotechnol 30: 283-288

Released	2011-07-20
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	QDR

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3SMJ \| pdb_00003smj	Download File View File

Human poly(ADP-ribose) polymerase 14 (Parp14/Artd8) - catalytic domain in complex with a pyrimidine-like inhibitor

Karlberg, T., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Edwards, A.M., Ekblad, T., Graslund, S., Kouznetsova, E., Nordlund, P., Nyman, T., Thorsell, A.G., Tresaugues, L., Weigelt, J., Schuler, H., Structural Genomics Consortium (SGC)

(2012) Nat Biotechnol 30: 283-288

Released	2011-07-20
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	FDR, GOL

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3VFQ \| pdb_00003vfq	Download File View File

Human PARP14 (ARTD8, BAL2) - macro domains 1 and 2 in complex with adenosine-5-diphosphoribose

Karlberg, T., Thorsell, A.G., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Ekblad, T., Weigelt, J., Schuler, H., Structural Genomics Consortium (SGC)

(2013) Structure 21: 462-475

Released	2013-03-13
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	AR6

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4D86 \| pdb_00004d86	Download File View File

Human PARP14 (ARTD8, BAL2) - macro domains 1 and 2 in complex with adenosine-5-diphosphate

Karlberg, T., Thorsell, A.G., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Ekblad, T., Weigelt, J., Schuler, H., Structural Genomics Consortium (SGC)

(2013) Structure 21: 462-475

Released	2013-03-13
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	ADP

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4F1L \| pdb_00004f1l	Download File View File

Human Artd8 (Parp14, Bal2) - catalytic domain in complex with inhibitor A16(Z)

Karlberg, T., Andersson, C.D., Lindgren, A., Spjut, S., Thorsell, A.G., Ekblad, T., Weigelt, J., Elofsson, M., Linusson, A., Schuler, H.

(2012) J Med Chem 55: 7706-7718

Released	2012-09-05
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	0RY, NO3

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4F1Q \| pdb_00004f1q	Download File View File

Human Artd8 (Parp14, Bal2) - catalytic domain in complex with A16(E)

Karlberg, T., Andersson, C.D., Lindgren, A., Spjut, S., Thorsell, A.G., Ekblad, T., Weigelt, J., Elofsson, M., Linusson, A., Schuler, H.

(2012) J Med Chem 55: 7706-7718

Released	2012-09-05
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	0RZ, NO3

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4PY4 \| pdb_00004py4	Download File View File

Crystal structure of human poly(ADP-ribose) polymerase 14, catalytic domain in complex with an inhibitor XL2

Li, J., Xu, Y.

(2017) Tetrahedron 70: 5666-5673

Released	2015-04-01
Method	X-RAY DIFFRACTION 2.76 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	XL2

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5LXP \| pdb_00005lxp	Download File View File

Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor H5

Karlberg, T., Thorsell, A.G., Schuler, H.

(2017) Angew Chem Int Ed Engl 56: 248-253

Released	2016-12-21
Method	X-RAY DIFFRACTION 2.07 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	7AG

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5LYH \| pdb_00005lyh	Download File View File

Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor H10

Karlberg, T., Thorsell, A.G., Schuler, H.

(2017) Angew Chem Int Ed Engl 56: 248-253

Released	2016-12-21
Method	X-RAY DIFFRACTION 2.17 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	7B8

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5NQE \| pdb_00005nqe	Download File View File

Human PARP14 (ARTD8), catalytic fragment in complex with an N-aryl piperazine inhibitor

Karlberg, T., Thorsell, A.G., Schuler, H.

(2017) Bioorg Med Chem Lett 27: 2907-2911

Released	2017-05-24
Method	X-RAY DIFFRACTION 2.71 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	94Z

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5O2D \| pdb_00005o2d	Download File View File

PARP14 Macrodomain 2 with inhibitor

Uth, K., Schuller, M., Sieg, C., Wang, J., Krojer, T., Knapp, S., Riedels, K., Bracher, F., Edwards, A.M., Arrowsmith, C., Bountra, C., Elkins, J.M., Structural Genomics Consortium (SGC)

(2017) ACS Chem Biol 12: 2866-2874

Released	2017-11-08
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	9HH

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5QHT \| pdb_00005qht	Download File View File

PanDDA analysis group deposition -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000065a

Schuller, M., Talon, R., Krojer, T., Brandao-Neto, J., Douangamath, A., Zhang, R., von Delft, F., Schuler, H., Kessler, B., Knapp, S., Bountra, C., Arrowsmith, C.H., Edwards, A., Elkins, J.

To be published

Released	2019-04-10
Method	X-RAY DIFFRACTION 1.05 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	CL, DMS, GQY

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5QHU \| pdb_00005qhu	Download File View File

PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMSOA000341b

Schuller, M., Talon, R., Krojer, T., Brandao-Neto, J., Douangamath, A., Zhang, R., von Delft, F., Schuler, H., Kessler, B., Knapp, S., Bountra, C., Arrowsmith, C.H., Edwards, A., Elkins, J.

To be published

Released	2019-04-10
Method	X-RAY DIFFRACTION 1.05 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	9KS, CL, DMS

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5QHV \| pdb_00005qhv	Download File View File

PanDDA analysis group deposition -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000299a

Schuller, M., Talon, R., Krojer, T., Brandao-Neto, J., Douangamath, A., Zhang, R., von Delft, F., Schuler, H., Kessler, B., Knapp, S., Bountra, C., Arrowsmith, C.H., Edwards, A., Elkins, J.

To be published

Released	2019-04-10
Method	X-RAY DIFFRACTION 1.05 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	AWP, CL, DMS

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5QHW \| pdb_00005qhw	Download File View File

PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000347a

Schuller, M., Talon, R., Krojer, T., Brandao-Neto, J., Douangamath, A., Zhang, R., von Delft, F., Schuler, H., Kessler, B., Knapp, S., Bountra, C., Arrowsmith, C.H., Edwards, A., Elkins, J.

To be published

Released	2019-04-10
Method	X-RAY DIFFRACTION 1.12 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	CL, DMS, GRV

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5QHX \| pdb_00005qhx	Download File View File

PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000278a

Schuller, M., Talon, R., Krojer, T., Brandao-Neto, J., Douangamath, A., Zhang, R., von Delft, F., Schuler, H., Kessler, B., Knapp, S., Bountra, C., Arrowsmith, C.H., Edwards, A., Elkins, J.

To be published

Released	2019-04-10
Method	X-RAY DIFFRACTION 1.11 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	CL, DMS, GRY

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5QHY \| pdb_00005qhy	Download File View File

PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000462a

Schuller, M., Talon, R., Krojer, T., Brandao-Neto, J., Douangamath, A., Zhang, R., von Delft, F., Schuler, H., Kessler, B., Knapp, S., Bountra, C., Arrowsmith, C.H., Edwards, A., Elkins, J.

To be published

Released	2019-04-10
Method	X-RAY DIFFRACTION 1.17 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	CL, DMS, GT4

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5QHZ \| pdb_00005qhz	Download File View File

PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000385a

Schuller, M., Talon, R., Krojer, T., Brandao-Neto, J., Douangamath, A., Zhang, R., von Delft, F., Schuler, H., Kessler, B., Knapp, S., Bountra, C., Arrowsmith, C.H., Edwards, A., Elkins, J.

To be published

Released	2019-04-10
Method	X-RAY DIFFRACTION 1.15 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	CL, DMS, GT7

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5QI0 \| pdb_00005qi0	Download File View File

PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000352a

Schuller, M., Talon, R., Krojer, T., Brandao-Neto, J., Douangamath, A., Zhang, R., von Delft, F., Schuler, H., Kessler, B., Knapp, S., Bountra, C., Arrowsmith, C.H., Edwards, A., Elkins, J.

To be published

Released	2019-04-10
Method	X-RAY DIFFRACTION 1.05 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	CL, DMS, GTJ

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5QI1 \| pdb_00005qi1	Download File View File

PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000474a

Schuller, M., Talon, R., Krojer, T., Brandao-Neto, J., Douangamath, A., Zhang, R., von Delft, F., Schuler, H., Kessler, B., Knapp, S., Bountra, C., Arrowsmith, C.H., Edwards, A., Elkins, J.

To be published

Released	2019-04-10
Method	X-RAY DIFFRACTION 1.05 Å
Organisms	Homo sapiens
Macromolecule	Poly [ADP-ribose] polymerase 14 (protein)
Unique Ligands	CL, DMS, GUG

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1X4R | pdb_00001x4r

3GOY | pdb_00003goy

3Q6Z | pdb_00003q6z

3Q71 | pdb_00003q71

3SE2 | pdb_00003se2

3SMI | pdb_00003smi

3SMJ | pdb_00003smj

3VFQ | pdb_00003vfq

4D86 | pdb_00004d86

4F1L | pdb_00004f1l

4F1Q | pdb_00004f1q

4PY4 | pdb_00004py4

5LXP | pdb_00005lxp

5LYH | pdb_00005lyh

5NQE | pdb_00005nqe

5O2D | pdb_00005o2d

5QHT | pdb_00005qht

5QHU | pdb_00005qhu

5QHV | pdb_00005qhv

5QHW | pdb_00005qhw

5QHX | pdb_00005qhx

5QHY | pdb_00005qhy

5QHZ | pdb_00005qhz

5QI0 | pdb_00005qi0

5QI1 | pdb_00005qi1