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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "MIP1"

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Search Summary

This query matches 31 Structures.

Refinements

Structure Determination Methodology

experimental (31)

Scientific Name of Source Organism

	Homo sapiens (27)
	Saccharomyces cerevisiae (4)
	synthetic construct (4)
	Saccharomyces cerevisiae S288C (1)
	Thermochaetoides thermophila DSM 1495 (1)

Taxonomy

	Eukaryota (31)
	other sequences (4)

Experimental Method

	X-RAY DIFFRACTION (19)
	ELECTRON MICROSCOPY (12)

Polymer Entity Type

	Protein (31)
	DNA (4)

Refinement Resolution (Å)

	1.5 - 2.0 (4)
	2.0 - 2.5 (3)
	2.5 - 3.0 (7)
	3.0 - 3.5 (13)
	3.5 - 4.0 (2)
	4.0 - 4.5 (1)
	> 4.5 (1)

Release Date

	2005 - 2009 (3)
	2010 - 2014 (3)
	2015 - 2019 (6)
	2020 - 2024 (15)
	2025 - 2029 (4)

Enzyme Classification Name

	Transferases (11)
	Hydrolases (7)

Symmetry Type

	Asymmetric (26)
	Cyclic (5)

SCOP Classification

	All alpha proteins (6)
	Alpha and beta proteins (a/b) (1)
	Artifacts (1)

AllSelected

1 to 25 of 31 Structures

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2H4M \| pdb_00002h4m	Download File View File

Karyopherin Beta2/Transportin-M9NLS

Chook, Y.M., Cansizoglu, A.E.

(2006) Cell 126: 543-558

Released	2006-10-24
Method	X-RAY DIFFRACTION 3.05 Å
Organisms	Homo sapiens
Macromolecule	Heterogeneous nuclear ribonucleoprotein A1 (protein) Transportin-1 (protein)

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2OT8 \| pdb_00002ot8	Download File View File

Karyopherin Beta2/Transportin-hnRNPM NLS Complex

Cansizoglu, A.E., Chook, Y.M.

(2007) Nat Struct Mol Biol 14: 452-454

Released	2007-04-10
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Heterogeneous nuclear ribonucleoprotein M (protein) Transportin-1 (protein)

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2QMR \| pdb_00002qmr	Download File View File

Karyopherin beta2/transportin

Cansizoglu, A.E., Chook, Y.M.

(2007) Structure 15: 1431-1441

Released	2007-10-30
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Transportin-1 (protein)

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4FDD \| pdb_00004fdd	Download File View File

Crystal structure of KAP beta2-PY-NLS

Zhang, Z.C., Chook, Y.M.

(2012) Proc Natl Acad Sci U S A 109: 12017-12021

Released	2012-07-18
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	RNA-binding protein FUS (protein) Transportin-1 (protein)

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4JLQ \| pdb_00004jlq	Download File View File

Crystal structure of human Karyopherin-beta2 bound to the PY-NLS of Saccharomyces cerevisiae NAB2

Sampathkumar, P., Gizzi, A., Rout, M.P., Chook, Y.M., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)

(2013) J Struct Funct Genomics 14: 31-35

Released	2013-04-03
Method	X-RAY DIFFRACTION 3.05 Å
Organisms	Homo sapiens Saccharomyces cerevisiae S288C
Macromolecule	Nuclear polyadenylated RNA-binding protein NAB2 (protein) Transportin-1 (protein)

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4OO6 \| pdb_00004oo6	Download File View File

Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1)

Sampathkumar, P., Brower, A., Soniat, M., Bonanno, J., Hillerich, B., Seidel, R.D., Rout, M.P., Chook, Y.M., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)

To be published

Released	2014-02-12
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	RNA-binding protein 39 (protein) Transportin-1 (protein)

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5J3V \| pdb_00005j3v	Download File View File

Crystal structure of human Karyopherin-beta2 bound to the histone H3 tail

Soniat, M., Chook, Y.M.

(2016) Structure 24: 1802-1809

Released	2016-09-21
Method	X-RAY DIFFRACTION 3.05 Å
Organisms	Homo sapiens
Macromolecule	Histone H3 (protein) Transportin-1,Transportin-1 (protein)

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5TQC \| pdb_00005tqc	Download File View File

Crystal structure of transport factor karyopherin-beta 2 in complex with the PY-NLS of ribosomal protein L4 (RpL4)

Huber, F.M., Hoelz, A.

(2017) Nat Commun 8: 14354-14354

Released	2017-02-15
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens Thermochaetoides thermophila DSM 1495
Macromolecule	60S ribosomal protein L4-like protein (protein) Transportin-1,Transportin-1 (protein)

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5YVG \| pdb_00005yvg	Download File View File

Crystal structure of Karyopherin beta2 in complex with FUS(full length)

Yoshizawa, T., Fung, H.Y.J., Chook, Y.M.

(2018) Cell 173: 693-705.e22

Released	2018-05-16
Method	X-RAY DIFFRACTION 4.05 Å
Organisms	Homo sapiens
Macromolecule	RNA-binding protein FUS (protein) Transportin-1 (protein)

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5YVH \| pdb_00005yvh	Download File View File

Crystal structure of Karyopherin beta2 in complex with FUS(371-526)

Yoshizawa, T., Fung, H.Y.J., Chook, Y.M.

(2018) Cell 173: 693-705.e22

Released	2018-05-16
Method	X-RAY DIFFRACTION 3.15 Å
Organisms	Homo sapiens
Macromolecule	RNA-binding protein FUS (protein) Transportin-1 (protein)

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5YVI \| pdb_00005yvi	Download File View File

Crystal structure of Karyopherin beta2 in complex with FUS(456-526)

Yoshizawa, T., Fung, H.Y.J., Chook, Y.M.

(2018) Cell 173: 693-705.e22

Released	2018-05-16
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	RNA-binding protein FUS (protein) Transportin-1 (protein)

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5ZCS \| pdb_00005zcs	Download File View File

4.9 Angstrom Cryo-EM structure of human mTOR complex 2

Chen, X., Liu, M., Tian, Y., Wang, H., Wang, J., Xu, Y.

(2018) Cell Res 28: 518-528

Released	2018-03-21
Method	ELECTRON MICROSCOPY 4.9 Å
Organisms	Homo sapiens
Macromolecule	Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)

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6ZWM \| pdb_00006zwm	Download File View File

cryo-EM structure of human mTOR complex 2, overall refinement

Scaiola, A., Mangia, F., Imseng, S., Boehringer, D., Ban, N., Maier, T.

(2020) Sci Adv 6:

Released	2020-11-18
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens
Macromolecule	Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	ACE, AGS, IHP, ZN

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6ZWO \| pdb_00006zwo	Download File View File

cryo-EM structure of human mTOR complex 2, focused on one half

Scaiola, A., Mangia, F., Imseng, S., Boehringer, D., Ban, N., Maier, T.

(2020) Sci Adv 6:

Released	2020-11-18
Method	ELECTRON MICROSCOPY 3 Å
Organisms	Homo sapiens
Macromolecule	Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	ACE, AGS, IHP, ZN

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7CYL \| pdb_00007cyl	Download File View File

Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)

Yoshizawa, T., Chook, Y.M.

(2021) Sci Rep 11: 3754-3754

Released	2021-02-24
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	RNA-binding protein FUS (protein) Transportin-1 (protein)

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7LC1 \| pdb_00007lc1	Download File View File

Crystal Structure of KRAS4b (GMPPNP-bound) in complex with the RBD-PH domains of SIN1

Dharmaiah, S., Simanshu, D.K.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-08-04
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Isoform 2B of GTPase KRas (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein)
Unique Ligands	GNP, MG

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7LC2 \| pdb_00007lc2	Download File View File

Crystal Structure of KRAS4b-Q61R (GMPPNP-bound) in complex with the RAS-binding domain (RBD) of SIN1

Dharmaiah, S., Simanshu, D.K.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-07-28
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein)
Unique Ligands	GNP, MG

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7PE7 \| pdb_00007pe7	Download File View File

cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement

Waelchli, M., Maier, T.

(2021) Elife 10:

Released	2021-09-15
Method	ELECTRON MICROSCOPY 3.41 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	ACE, IHP, ZN

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7PE8 \| pdb_00007pe8	Download File View File

cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer

Waelchli, M., Maier, T.

(2021) Elife 10:

Released	2021-09-08
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	ACE, IHP, ZN

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7PE9 \| pdb_00007pe9	Download File View File

cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement

Waelchli, M., Maier, T.

(2021) Elife 10:

Released	2021-09-08
Method	ELECTRON MICROSCOPY 3.7 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	ACE, IHP, ZN

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7TZO \| pdb_00007tzo	Download File View File

The apo structure of human mTORC2 complex

Yu, Z., Chen, J., Pearce, D.

(2022) J Biological Chem 298: 102288-102288

Released	2023-01-11
Method	ELECTRON MICROSCOPY 3.28 Å
Organisms	Homo sapiens
Macromolecule	Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)

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7VPW \| pdb_00007vpw	Download File View File

Crystal structure of Transportin-1 in complex with BAP1 PY-NLS (residues 706-724)

Yang, T.J., Hsu, S.T.D.

(2022) J Cell Biol 221:

Released	2022-04-20
Method	X-RAY DIFFRACTION 3.76 Å
Organisms	Homo sapiens
Macromolecule	BRCA1-associated protein 1 (BAP1) (protein) Transportin-1 (protein)

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7VV8 \| pdb_00007vv8	Download File View File

Crystal Structure of HRasQ61L(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1

Zheng, Y.Y., Zhou, C.

(2022) Proc Natl Acad Sci U S A 119: e2119990119-e2119990119

Released	2022-05-18
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	GTPase HRas (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein)
Unique Ligands	GNP, MG

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7VV9 \| pdb_00007vv9	Download File View File

Crystal Structure of HRas(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1

Zheng, Y.Y., Zhou, C.

(2022) Proc Natl Acad Sci U S A 119: e2119990119-e2119990119

Released	2022-05-18
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	GTPase HRas (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein)
Unique Ligands	GNP, MG

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7VVB \| pdb_00007vvb	Download File View File

Crystal Structure of KRas4A(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1

Zheng, Y.Y., Zhou, C.

(2022) Proc Natl Acad Sci U S A 119: e2119990119-e2119990119

Released	2022-05-18
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein)
Unique Ligands	GNP, MG

1 to 25 of 31 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2H4M | pdb_00002h4m

2OT8 | pdb_00002ot8

2QMR | pdb_00002qmr

4FDD | pdb_00004fdd

4JLQ | pdb_00004jlq

4OO6 | pdb_00004oo6

5J3V | pdb_00005j3v

5TQC | pdb_00005tqc

5YVG | pdb_00005yvg

5YVH | pdb_00005yvh

5YVI | pdb_00005yvi

5ZCS | pdb_00005zcs

6ZWM | pdb_00006zwm

6ZWO | pdb_00006zwo

7CYL | pdb_00007cyl

7LC1 | pdb_00007lc1

7LC2 | pdb_00007lc2

7PE7 | pdb_00007pe7

7PE8 | pdb_00007pe8

7PE9 | pdb_00007pe9

7TZO | pdb_00007tzo

7VPW | pdb_00007vpw

7VV8 | pdb_00007vv8

7VV9 | pdb_00007vv9

7VVB | pdb_00007vvb