RCSB PDB: Search

2IAE \| pdb_00002iae	Download File View File

Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme.

Cho, U.S., Xu, W.

(2007) Nature 445: 53-57

Released	2006-12-26
Method	X-RAY DIFFRACTION 3.5 Å
Organisms	Homo sapiens Microcystis aeruginosa Mus musculus
Macromolecule	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) microcystin-LR (protein)
Unique Ligands	MN

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2NPP \| pdb_00002npp	Download File View File

Structure of the Protein Phosphatase 2A Holoenzyme

Xu, Y., Chen, Y., Xing, Y., Chao, Y., Shi, Y.

(2006) Cell 127: 1239-1251

Released	2006-12-12
Method	X-RAY DIFFRACTION 3.3 Å
Organisms	Cyanobacteriota Homo sapiens
Macromolecule	Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) microcystin LR (protein)
Unique Ligands	MN

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2NYL \| pdb_00002nyl	Download File View File

Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated

Xing, Y., Xu, Y., Chen, Y., Chao, Y., Lin, Z., Shi, Y.

(2006) Cell 127: 1239-1251

Released	2006-12-12
Method	X-RAY DIFFRACTION 3.8 Å
Organisms	Cyanobacteriota Homo sapiens
Macromolecule	Protein phosphatase 2, regulatory subunit A (PR 65), alpha isoform (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) microcystin LR (protein)
Unique Ligands	MN

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2NYM \| pdb_00002nym	Download File View File

Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit

Chen, Y., Xing, Y., Xu, Y., Chao, Y., Lin, Z., Jeffrey, P.D., Shi, Y.

(2006) Cell 127: 1239-1251

Released	2006-12-12
Method	X-RAY DIFFRACTION 3.6 Å
Organisms	Cyanobacteriota Homo sapiens
Macromolecule	Protein phosphatase 2 (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) microcystin LR (protein)
Unique Ligands	MN

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3FGA \| pdb_00003fga	Download File View File

Structural Basis of PP2A and Sgo interaction

Xu, Z., Xu, W.

(2009) Mol Cell 35: 426-441

Released	2009-09-22
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens Microcystis aeruginosa Mus musculus
Macromolecule	MICROCYSTIN-LR (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein) Shugoshin-like 1 (protein)
Unique Ligands	MN

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5JJA \| pdb_00005jja	Download File View File

Crystal structure of a PP2A B56gamma/BubR1 complex

Wang, Z., Wang, J., Rao, Z., Xu, W.

(2016) Protein Cell 7: 516-526

Released	2016-07-13
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein)

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5K6S \| pdb_00005k6s	Download File View File

The structure of the PP2A B56 subunit BubR1 complex

Page, R., Wang, X., Bajaj, R., Peti, W.

(2016) Structure 24: 2174-2181

Released	2016-12-07
Method	X-RAY DIFFRACTION 2.794 Å
Organisms	Homo sapiens
Macromolecule	BubR1 (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein)

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5SW9 \| pdb_00005sw9	Download File View File

The structure of the PP2A B56 subunit RepoMan complex

Page, R., Wang, X., Bajaj, R., Peti, W.

(2016) Structure 24: 2174-2181

Released	2016-11-30
Method	X-RAY DIFFRACTION 2.846 Å
Organisms	Homo sapiens
Macromolecule	RepoMan (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein)

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5SWF \| pdb_00005swf	Download File View File

The structure of the PP2A B56 subunit double phosphorylated BubR1 complex

Page, R., Wang, X., Bajaj, R., Peti, W.

(2016) Structure 24: 2174-2181

Released	2016-11-30
Method	X-RAY DIFFRACTION 2.818 Å
Organisms	Homo sapiens
Macromolecule	Double phosphorylated BubR1 (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein)

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6OYL \| pdb_00006oyl	Download File View File

The structure of the PP2A B56 subunit KIF4A complex

Wang, X., Page, R., Peti, W.

(2020) Elife 9:

Released	2020-03-25
Method	X-RAY DIFFRACTION 3.15 Å
Organisms	Homo sapiens
Macromolecule	Chromosome-associated kinesin KIF4A (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein)

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6TOQ \| pdb_00006toq	Download File View File

Crystal structure of a PP2A B56y/HTLV-1 integrase complex

Minnell, J.J., Barski, M.S., Maertens, G.N.

(2020) Nat Commun 11: 5043-5043

Released	2020-10-21
Method	X-RAY DIFFRACTION 3.164 Å
Organisms	Homo sapiens Human T-cell leukemia virus type I
Macromolecule	Pol protein (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein)

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6VOY \| pdb_00006voy	Download File View File

Cryo-EM structure of HTLV-1 instasome

Bhatt, V., Shi, K., Sundborger, A., Aihara, H.

(2020) Nat Commun 11: 3121-3121

Released	2020-07-01
Method	ELECTRON MICROSCOPY 3.7 Å
Organisms	Homo sapiens Human T-cell leukemia virus type I Saccharolobus solfataricus P2
Macromolecule	DNA-binding protein 7d (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) DNA (25-MER) (nucleic acid) DNA (5'-D(PAPCPAPCPAPCPTPTPGPAPCPTPAPGPGPGPTPG)-3') (nucleic acid)
Unique Ligands	MG, ZN

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6VRO \| pdb_00006vro	Download File View File

The structure of the PP2A B56 subunit AIM1 complex

Wang, X., Page, R., Peti, W.

(2020) Elife 9:

Released	2020-03-25
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Homo sapiens
Macromolecule	Beta/gamma crystallin domain-containing protein 1 (protein) Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein)

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7OUF \| pdb_00007ouf	Download File View File

Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor XZ450

Barski, M.S., Ballandras-Colas, A., Cronin, N.B., Pye, V.E., Cherepanov, P., Maertens, G.N.

(2021) Nat Commun 12: 4996-4996

Released	2021-08-18
Method	ELECTRON MICROSCOPY 3 Å
Organisms	Homo sapiens Simian T-lymphotropic virus 1
Macromolecule	Integrase (protein) Isoform 3 of PC4 and SFRS1-interacting protein,Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) DNA (5'-D(APCPTPGPTPGPTPTPTPGPGPCPGPCPTPTPCPTPCPTPC)-3') (nucleic acid) DNA (5'-D(GPAPGPAPGPAPAPGPCPGPCPCPAPAPAPCPAPCPA)-3') (nucleic acid)
Unique Ligands	1L0, MG, ZN

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7OUG \| pdb_00007oug	Download File View File

STLV-1 intasome:B56 in complex with the strand-transfer inhibitor raltegravir

Barski, M.S., Ballandras-Colas, A., Cronin, N.B., Pye, V.E., Cherepanov, P., Maertens, G.N.

(2021) Nat Commun 12: 4996-4996

Released	2021-08-18
Method	ELECTRON MICROSCOPY 3.1 Å
Organisms	Homo sapiens Simian T-lymphotropic virus 1
Macromolecule	Integrase (protein) Isoform 3 of PC4 and SFRS1-interacting protein,Isoform Gamma-2 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) DNA (5'-D(APCPTPGPTPGPTPTPTPGPGPCPGPCPTPTPCPTPCPTPC)-3') (nucleic acid) DNA (5'-D(GPAPGPAPGPAPAPGPCPGPCPCPAPAPAPCPAPCPA)-3') (nucleic acid)
Unique Ligands	MG, RLT, ZN

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7OUH \| pdb_00007ouh	Download File View File

Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor bictegravir

Barski, M.S., Ballandras-Colas, A., Cronin, N.B., Pye, V.E., Cherepanov, P., Maertens, G.N.

(2021) Nat Commun 12: 4996-4996

Released	2021-08-18
Method	ELECTRON MICROSCOPY 3.5 Å
Organisms	Homo sapiens Simian T-lymphotropic virus 1
Macromolecule	Integrase (protein) PC4 and SFRS1-interacting protein,Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) DNA (5'-D(APCPTPGPTPGPTPTPTPGPGPCPGPCPTPTPCPTPCPTPC)-3') (nucleic acid) DNA (5'-D(GPAPGPAPGPAPAPGPCPGPCPCPAPAPAPCPAPCPA)-3') (nucleic acid)
Unique Ligands	KLQ, MG, ZN

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7PEL \| pdb_00007pel	Download File View File

CryoEM structure of simian T-cell lymphotropic virus intasome in complex with PP2A regulatory subunit B56 gamma

Barski, M., Pye, V.E., Nans, A., Cherepanov, P., Maertens, G.N.

(2020) Nat Commun 11: 5043

Released	2021-08-25
Method	ELECTRON MICROSCOPY 3.34 Å
Organisms	Homo sapiens Simian T-lymphotropic virus 1 synthetic construct
Macromolecule	Isoform 3 of PC4 and SFRS1-interacting protein,Isoform Gamma-2 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) Pol protein (protein) DNA (5'-D(APCPTPGPTPGPTPTPTPGPGPCPGPCPTPTPCPTPCPTPC)-3') (nucleic acid) DNA (5'-D(GPAPGPAPGPAPAPGPCPGPCPCPAPAPAPCPAPCPA)-3') (nucleic acid)
Unique Ligands	ZN

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7SOY \| pdb_00007soy	Download File View File

The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex

Li, Y., Balakrishnan, V.K., Rowse, M., Novikova, I.V., Xing, Y.

(2022) Elife 11:

Released	2022-08-31
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Homo sapiens
Macromolecule	Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (protein) Protein phosphatase methylesterase 1 (protein) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (protein) Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (protein)

2IAE | pdb_00002iae

Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme.

2NPP | pdb_00002npp

Structure of the Protein Phosphatase 2A Holoenzyme

2NYL | pdb_00002nyl

Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated

2NYM | pdb_00002nym

Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit

3FGA | pdb_00003fga

Structural Basis of PP2A and Sgo interaction

5JJA | pdb_00005jja

Crystal structure of a PP2A B56gamma/BubR1 complex

5K6S | pdb_00005k6s

The structure of the PP2A B56 subunit BubR1 complex

5SW9 | pdb_00005sw9

The structure of the PP2A B56 subunit RepoMan complex

5SWF | pdb_00005swf

The structure of the PP2A B56 subunit double phosphorylated BubR1 complex

6OYL | pdb_00006oyl

The structure of the PP2A B56 subunit KIF4A complex

6TOQ | pdb_00006toq

Crystal structure of a PP2A B56y/HTLV-1 integrase complex

6VOY | pdb_00006voy

Cryo-EM structure of HTLV-1 instasome

6VRO | pdb_00006vro

The structure of the PP2A B56 subunit AIM1 complex

7OUF | pdb_00007ouf

Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor XZ450

7OUG | pdb_00007oug

STLV-1 intasome:B56 in complex with the strand-transfer inhibitor raltegravir

7OUH | pdb_00007ouh

Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor bictegravir

7PEL | pdb_00007pel

CryoEM structure of simian T-cell lymphotropic virus intasome in complex with PP2A regulatory subunit B56 gamma

7SOY | pdb_00007soy

The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2IAE | pdb_00002iae

2NPP | pdb_00002npp

2NYL | pdb_00002nyl

2NYM | pdb_00002nym

3FGA | pdb_00003fga

5JJA | pdb_00005jja

5K6S | pdb_00005k6s

5SW9 | pdb_00005sw9

5SWF | pdb_00005swf

6OYL | pdb_00006oyl

6TOQ | pdb_00006toq

6VOY | pdb_00006voy

6VRO | pdb_00006vro

7OUF | pdb_00007ouf

7OUG | pdb_00007oug

7OUH | pdb_00007ouh

7PEL | pdb_00007pel

7SOY | pdb_00007soy