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232,829 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "HAUSP"

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Search Summary

This query matches 71 Structures.

Refinements

Structure Determination Methodology

experimental (71)

Scientific Name of Source Organism

	Homo sapiens (71)
	synthetic construct (6)
	Human alphaherpesvirus 1 strain 17 (2)
	Epstein-Barr virus (strain B95-8) (1)
	Human alphaherpesvirus 1 (1)
	Human gammaherpesvirus 8 (1)

Taxonomy

	Eukaryota (71)
	other sequences (6)
	Duplodnaviria (5)
	Eukaryota (eukaryotes) (3)

Experimental Method

	X-RAY DIFFRACTION (70)
	SOLUTION NMR (1)

Polymer Entity Type

Protein (71)

Refinement Resolution (Å)

	1.0 - 1.5 (3)
	1.5 - 2.0 (11)
	2.0 - 2.5 (23)
	2.5 - 3.0 (23)
	3.0 - 3.5 (10)

Release Date

	2005 - 2009 (7)
	2010 - 2014 (8)
	2015 - 2019 (28)
	2020 - 2024 (20)
	2025 - 2029 (8)

Enzyme Classification Name

	Hydrolases (71)
	Transferases (12)
	Ligases (3)

Symmetry Type

	Asymmetric (66)
	Cyclic (6)
	Dihedral (2)

SCOP Classification

	Alpha and beta proteins (a+b) (23)
	Artifacts (4)

AllSelected

1 to 25 of 71 Structures

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1YY6	Download File View File

The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with an EBNA1 peptide

Saridakis, V., Sheng, Y., Sarkari, F., Holowaty, M., Shire, K., Nguyen, T., Zhang, R., Liao, J., Lee, W., Edwards, A.M., Arrowsmith, C.H., Frappier, L.

(2005) Mol Cell 18: 25-36

Released	2005-04-05
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Epstein-Barr virus (strain B95-8) Homo sapiens
Macromolecule	Epstein-Barr nuclear antigen-1 (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)
Unique Ligands	NA

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1YZE	Download File View File

Crystal structure of the N-terminal domain of USP7/HAUSP.

Saridakis, V., Sheng, Y., Sarkari, F., Holowaty, M.N., Shire, K., Nguyen, T., Zhang, R.G., Liao, J., Lee, W., Edwards, A.M., Arrowsmith, C.H., Frappier, L.

(2005) Mol Cell 18: 25-36

Released	2005-04-05
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein)

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2F1W	Download File View File

Crystal structure of the TRAF-like domain of HAUSP/USP7

Hu, M., Gu, L., Jeffrey, P.D., Shi, Y.

(2006) PLoS Biol 4: e27-e27

Released	2006-02-07
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein)
Unique Ligands	CA

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2F1Z	Download File View File

Crystal structure of HAUSP

Hu, M., Gu, L., Jeffrey, P.D., Shi, Y.

(2006) PLoS Biol 4: e27-e27

Released	2006-02-07
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein)

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2FOJ	Download File View File

The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 364-367

Saridakis, V., Sheng, Y., Sarkari, F., Duan, S., Wu, T., Arrowsmith, C.H., Frappier, L.

(2006) Nat Struct Mol Biol 13: 285-291

Released	2006-02-14
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein) p53 peptide (protein)

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2FOO	Download File View File

The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 359-362

Saridakis, V., Sheng, Y., Sarkari, F., Duan, S., Wu, T., Arrowsmith, C.H., Frappier, L.

(2006) Nat Struct Mol Biol 13: 285-291

Released	2006-02-14
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein) p53 peptide (protein)

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2FOP	Download File View File

The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with mdm2 peptide 147-150

Saridakis, V., Sheng, Y., Sarkari, F., Duan, S., Wu, T., Arrowsmith, C.H., Frappier, L.

(2006) Nat Struct Mol Biol 13: 285-291

Released	2006-02-14
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein) mdm2 peptide (protein)

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2KVR	Download File View File

Solution NMR structure of human ubiquitin specific protease Usp7 UBL domain (residues 537-664). NESG target hr4395c/ SGC-Toronto

Bezsonova, I., Lemak, A., Avvakumov, G., Xue, S., Dhe-Paganon, S., Montelione, G.T., Arrowsmith, C., Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC)

To be published

Released	2010-04-21
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein)

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3MQR	Download File View File

Crystal Structure of the USP7:HdmX(AHSS) complex

Saridakis, V.

To be published

Released	2010-08-25
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	HdmX Peptide (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)

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3MQS	Download File View File

Crystal Structure of the USP7:Hdm2(PSTS) complex

Saridakis, V.

To be published

Released	2010-08-25
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Hdm2 peptide (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)

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4JJQ	Download File View File

Crystal structure of usp7-ntd with an e2 enzyme

Saridakis, V.

(2013) J Biological Chem 288: 16975-16985

Released	2013-05-01
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein) Ubiquitin-conjugating enzyme E2 E1 (protein)

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4KG9	Download File View File

Crystal Structure Of USP7-NTD with MCM-BP

Saridakis, V., Luthra, N.

(2014) Mol Cell Biol 34: 132-145

Released	2013-11-13
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Mini-chromosome maintenance complex-binding protein (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)

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4M5W	Download File View File

Crystal structure of the USP7/HAUSP catalytic domain

Molland, K.L., Mesecar, A.D., Zhou, Q.

(2014) Acta Crystallogr Sect F Struct Biol Cryst Commun 70: 283-287

Released	2014-03-12
Method	X-RAY DIFFRACTION 2.244 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein)
Unique Ligands	BR

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4M5X	Download File View File

Crystal structure of the USP7/HAUSP catalytic domain

Mesecar, A.D., Molland, K.L., Zhou, Q.

(2014) Acta Crystallogr Sect F Struct Biol Cryst Commun 70: 283-287

Released	2014-03-12
Method	X-RAY DIFFRACTION 2.187 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein)
Unique Ligands	BR

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4PYZ	Download File View File

Crystal structure of the first two Ubl domains of Deubiquitylase USP7

Walker, J.R., Dong, A., Ong, M.S., Dhe-Paganon, S., Kania, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)

To be published

Released	2014-04-16
Method	X-RAY DIFFRACTION 2.84 Å
Organisms	Homo sapiens
Macromolecule	Ubiquitin carboxyl-terminal hydrolase 7 (protein)
Unique Ligands	UNX

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4WPH	Download File View File

Crystal structure of USP7 ubiquitin-like domains in compact conformation

Pfoh, R., Lacdao, I., Saridakis, V.

(2015) PLoS Pathog 11: e1004950-e1004950

Released	2015-06-17
Method	X-RAY DIFFRACTION 2.92 Å
Organisms	Homo sapiens Human alphaherpesvirus 1 strain 17
Macromolecule	ICP0 (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)
Unique Ligands	CL

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4WPI	Download File View File

Crystal structure of USP7 ubiquitin-like domains in extended conformation

Pfoh, R., Lacdao, I.K.L., Saridakis, V.

(2015) PLoS Pathog 11: e1004950-e1004950

Released	2015-06-17
Method	X-RAY DIFFRACTION 3.4 Å
Organisms	Homo sapiens Human alphaherpesvirus 1 strain 17
Macromolecule	ICP0 (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)
Unique Ligands	CL

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4YOC	Download File View File

Crystal Structure of human DNMT1 and USP7/HAUSP complex

Cheng, J., Yang, H., Fang, J., Gong, R., Wang, P., Li, Z., Xu, Y.

(2015) Nat Commun 6: 7023-7023

Released	2015-05-27
Method	X-RAY DIFFRACTION 2.916 Å
Organisms	Homo sapiens
Macromolecule	DNA (cytosine-5)-methyltransferase 1 (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)
Unique Ligands	ZN

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4YSI	Download File View File

Structure of USP7 with a novel viral protein

Chavoshi, S., Saridakis, V.

(2016) J Biological Chem

Released	2016-02-03
Method	X-RAY DIFFRACTION 1.02 Å
Organisms	Homo sapiens Human gammaherpesvirus 8
Macromolecule	SER-PRO-GLY-GLU-GLY-PRO-SER-GLY (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)
Unique Ligands	GOL

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4Z96	Download File View File

Crystal structure of DNMT1 in complex with USP7

Zhang, Z.M., Song, J.

To be published

Released	2016-10-12
Method	X-RAY DIFFRACTION 2.85 Å
Organisms	Homo sapiens
Macromolecule	DNA (cytosine-5)-methyltransferase 1 (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)

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4Z97	Download File View File

Crystal structure of USP7 in complex with DNMT1(K1115Q)

Zhang, Z.M., Song, J.

To be published

Released	2016-10-12
Method	X-RAY DIFFRACTION 2.998 Å
Organisms	Homo sapiens
Macromolecule	DNA (cytosine-5)-methyltransferase 1 (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)
Unique Ligands	GOL

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5C56	Download File View File

Crystal structure of USP7/HAUSP in complex with ICP0

Cheng, J., Li, Z., Gong, R., Fang, J., Yang, Y., Sun, C., Yang, H., Xu, Y.

(2015) Protein Cell 6: 849-852

Released	2015-07-08
Method	X-RAY DIFFRACTION 2.685 Å
Organisms	Homo sapiens Human alphaherpesvirus 1
Macromolecule	Ubiquitin E3 ligase ICP0 (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)

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5C6D	Download File View File

Crystal structure of USP7 in complex with UHRF1

Zhang, Z.-M., Song, J.

(2015) Cell Rep 12: 1400-1406

Released	2015-09-09
Method	X-RAY DIFFRACTION 2.292 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase UHRF1 (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)

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5GG4	Download File View File

Crystal structure of USP7 with RNF169 peptide

Jiang, Y., Gong, Q.

(2017) Proc Natl Acad Sci U S A 114: E2872-E2881

Released	2017-03-22
Method	X-RAY DIFFRACTION 3.11 Å
Organisms	Homo sapiens
Macromolecule	Peptide from E3 ubiquitin-protein ligase RNF169 (protein) Ubiquitin carboxyl-terminal hydrolase 7 (protein)