RCSB PDB: Search

3BRW	Download File View File

Structure of the Rap-RapGAP complex

Scrima, A., Thomas, C., Deaconescu, D., Wittinghofer, A.

(2008) EMBO J 27: 1145-1153

Released	2008-03-11
Method	X-RAY DIFFRACTION 3.4 Å
Organisms	Homo sapiens
Macromolecule	Rap1 GTPase-activating protein 1 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	BEF, GDP, MG

3CF6	Download File View File

Structure of Epac2 in complex with cyclic-AMP and Rap

Rehmann, H., Arias-Palomo, E., Hadders, M.A., Schwede, F., Llorca, O., Bos, J.L.

(2008) Nature 455: 124-127

Released	2008-07-29
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Rap guanine nucleotide exchange factor (GEF) 4 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	SO4, SP1

3X1W	Download File View File

Ras-related protein Rap1B with GDP

Noguchi, H., Ikegami, T., Akashi, S., Park, S.Y., Tame, J.R.H., Unzai, S.

(2015) Biochem Biophys Res Commun 462: 46-51

Released	2015-06-03
Method	X-RAY DIFFRACTION 1.2 Å
Organisms	Rattus norvegicus
Macromolecule	Ras-related protein Rap-1b (protein)
Unique Ligands	CD, GDP, MG

3X1X	Download File View File

Ras-related protein Rap1B with GppNHp

Noguchi, H., Ikegami, T., Park, S.Y., Tame, J.R.H., Unzai, S.

(2015) Biochem Biophys Res Commun 462: 46-51

Released	2015-06-03
Method	X-RAY DIFFRACTION 1 Å
Organisms	Rattus norvegicus
Macromolecule	Ras-related protein Rap-1b (protein)
Unique Ligands	CD, GNP, MG

3X1Y	Download File View File

Ras-related protein Rap1B(L9V) with GppNHp

Noguchi, H., Ikegami, T., Park, S.Y., Tame, J.R.H., Unzai, S.

(2015) Biochem Biophys Res Commun 462: 46-51

Released	2015-06-03
Method	X-RAY DIFFRACTION 1.168 Å
Organisms	Rattus norvegicus
Macromolecule	Ras-related protein Rap-1b (protein)
Unique Ligands	CD, GNP, GOL, MG

3X1Z	Download File View File

Ras-related protein Rap1B(T65A) with GppNHp

Noguchi, H., Ikegami, T., Park, S.Y., Tame, J.R.H., Unzai, S.

(2015) Biochem Biophys Res Commun 462: 46-51

Released	2015-06-03
Method	X-RAY DIFFRACTION 1.25 Å
Organisms	Rattus norvegicus
Macromolecule	Ras-related protein Rap-1b (protein)
Unique Ligands	GNP, GOL, MG

4DXA	Download File View File

Co-crystal structure of Rap1 in complex with KRIT1

Li, X., Zhang, R., Boggon, T.J.

(2012) J Biological Chem 287: 22317-22327

Released	2012-05-16
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Krev interaction trapped protein 1 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	GSP, MG

4HDO	Download File View File

Crystal structure of the binary Complex of KRIT1 bound to the Rap1 GTPase

(2013) J Biological Chem 288: 23639-23649

Released	2013-07-10
Method	X-RAY DIFFRACTION 1.67 Å
Organisms	Homo sapiens
Macromolecule	Krev interaction trapped protein 1 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	GNP, GOL, MG

4HDQ	Download File View File

Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and the Heart of Glass (HEG1) cytoplasmic tail

(2013) J Biological Chem 288: 23639-23649

Released	2013-07-10
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Krev interaction trapped protein 1 (protein) Protein HEG homolog 1 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	GNP, GOL, MG

4M8N	Download File View File

Crystal Structure of PlexinC1/Rap1B Complex

Pascoe, H.G., Wang, Y., Brautigam, C.A., He, H., Zhang, X.

(2013) Elife 2: e01279-e01279

Released	2013-10-09
Method	X-RAY DIFFRACTION 3.294 Å
Organisms	Danio rerio Homo sapiens
Macromolecule	PlexinC1 Intracellular Region (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	AF3, GDP, MG

4MGI	Download File View File

Selective activation of Epac1 and Epac2

To be published

Released	2014-09-03
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Rap guanine nucleotide exchange factor 4 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	CMP, SO4

4MGK	Download File View File

Selective activation of Epac1 and Epac2

To be published

Released	2014-09-03
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Rap guanine nucleotide exchange factor 4 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	CMP, SO4

4MGY	Download File View File

Selective activation of Epac1 and Epac2

To be published

Released	2014-09-03
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Rap guanine nucleotide exchange factor 4 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	H07, SO4

4MGZ	Download File View File

Selective activation of Epac1 and Epac2

To be published

Released	2014-09-03
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Rap guanine nucleotide exchange factor 4 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	HR6, SO4

4MH0	Download File View File

Selective activation of Epac1 and Epac2

To be published

Released	2014-09-03
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Rap guanine nucleotide exchange factor 4 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	HR4, SO4

5KHO	Download File View File

Rasip1 RA domain in complex with Rap1B

(2016) Structure 24: 2152-2162

Released	2016-10-19
Method	X-RAY DIFFRACTION 2.78 Å
Organisms	Homo sapiens
Macromolecule	Ras-interacting protein 1 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	GNP, GOL, MG

6AXF	Download File View File

Structure of RasGRP2 in complex with Rap1B

Kondo, Y., Iwig, J.S., Kuriyan, J.

(2017) Elife 6:

Released	2017-10-11
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	RAS guanyl-releasing protein 2 (protein) Ras-related protein Rap-1b (protein)

6BA6	Download File View File

Solution structure of Rap1b/talin complex

Zhu, L., Yang, J., Qin, J.

(2017) Nat Commun 8: 1744-1744

Released	2017-12-06
Method	SOLUTION NMR
Organisms	Homo sapiens Mus musculus
Macromolecule	Ras-related protein Rap-1b (protein) Talin-1 (protein)

6KYK	Download File View File

Crystal structure of Shank3 NTD-ANK mutant in complex with Rap1

Cai, Q., Zhang, M.

(2020) Structure 28: 290

Released	2019-12-04
Method	X-RAY DIFFRACTION 2.82 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Ras-related protein Rap-1b (protein) SH3 and multiple ankyrin repeat domains protein 3 (protein)
Unique Ligands	GNP, MG

6OQ3	Download File View File

Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi2

(2021) FASEB Bioadv

Released	2020-06-24
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Krev interaction trapped protein 1 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	7WO, GNP, MG

6OQ4	Download File View File

Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi1

(2021) FASEB Bioadv

Released	2020-06-24
Method	X-RAY DIFFRACTION 1.754 Å
Organisms	Homo sapiens
Macromolecule	Krev interaction trapped protein 1 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	GNP, MG, N0G

6UZK	Download File View File

Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi6

(2021) FASEB Bioadv 3: 334-355

Released	2020-11-18
Method	X-RAY DIFFRACTION 1.924 Å
Organisms	Homo sapiens
Macromolecule	Krev interaction trapped protein 1 (protein) Ras-related protein Rap-1b (protein)
Unique Ligands	GNP, MG, QMA

7C7I	Download File View File

Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(E30D,K31E)

Xiao, L.X., Pan, L.F.

(2020) Chin J Chem 38: 1635-1641

Released	2021-05-05
Method	X-RAY DIFFRACTION 2.28 Å
Organisms	Homo sapiens
Macromolecule	Ras-related protein Rap-1b (protein) SH3 and multiple ankyrin repeat domains protein 3 (protein)
Unique Ligands	CA, GTP, MG

7C7J	Download File View File

Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(G12V,Q63E)

Xiao, L.X., Pan, L.F.

(2020) Chin J Chem 38: 1635-1641

Released	2021-05-05
Method	X-RAY DIFFRACTION 2.39 Å
Organisms	Homo sapiens
Macromolecule	Ras-related protein Rap-1b (protein) SH3 and multiple ankyrin repeat domains protein 3 (protein)
Unique Ligands	CA, GTP, MG