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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "FLT2"

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Search Summary

This query matches 55 Structures.

Refinements

Structure Determination Methodology

experimental (55)

Scientific Name of Source Organism

	Homo sapiens (55)
	Rattus norvegicus (1)

Taxonomy

Eukaryota (55)

Experimental Method

	X-RAY DIFFRACTION (53)
	ELECTRON MICROSCOPY (2)

Polymer Entity Type

Protein (55)

Refinement Resolution (Å)

	1.5 - 2.0 (9)
	2.0 - 2.5 (26)
	2.5 - 3.0 (17)
	3.0 - 3.5 (2)
	4.0 - 4.5 (1)

Release Date

	2005 - 2009 (4)
	2010 - 2014 (13)
	2015 - 2019 (25)
	2020 - 2024 (13)

Enzyme Classification Name

	Transferases (55)
	Hydrolases (4)

Symmetry Type

	Asymmetric (50)
	Cyclic (9)

SCOP Classification

	Alpha and beta proteins (a+b) (38)
	All beta proteins (3)
	Artifacts (4)

AllSelected

1 to 25 of 55 Structures

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3C4F \| pdb_00003c4f	Download File View File

FGFR TYROSINE KINASE DOMAIN IN COMPLEX WITH 3-(3-methoxybenzyl)-7-azaindole

Zhang, K.Y.J., Wang, W.

(2008) Proc Natl Acad Sci U S A 105: 3041-3046

Released	2008-02-26
Method	X-RAY DIFFRACTION 2.07 Å
Organisms	Homo sapiens
Macromolecule	Basic fibroblast growth factor receptor 1 (protein)
Unique Ligands	C4F

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3DPK \| pdb_00003dpk	Download File View File

cFMS tyrosine kinase in complex with a pyridopyrimidinone inhibitor

Schubert, C.

(2009) J Med Chem 52: 1081-1099

Released	2009-02-17
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Macrophage colony-stimulating factor 1 receptor, Fibroblast growth factor receptor 1 (protein)
Unique Ligands	8C5, SO4

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3GQI \| pdb_00003gqi	Download File View File

Crystal Structure of activated receptor tyrosine kinase in complex with substrates

Bae, J.H., Lew, E.D., Yuzawa, S., Tome, F., Lax, I., Schlessinger, J.

(2009) Cell 138: 514-524

Released	2009-08-18
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens Rattus norvegicus
Macromolecule	Basic fibroblast growth factor receptor 1 (protein) Phospholipase C-gamma-1 (protein)
Unique Ligands	ACP, DVT, MG

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3GQL \| pdb_00003gql	Download File View File

Crystal Structure of activated receptor tyrosine kinase in complex with substrates

Bae, J.H., Lew, E.D., Yuzawa, S., Tome, F., Lax, I., Schlessinger, J.

(2009) Cell 138: 514-524

Released	2009-08-18
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Basic fibroblast growth factor receptor 1 (protein)
Unique Ligands	GQL

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3JS2 \| pdb_00003js2	Download File View File

Crystal structure of minimal kinase domain of fibroblast growth factor receptor 1 in complex with 5-(2-thienyl)nicotinic acid

Bae, J.H., Ravindranathan, K.P., Mandiyan, V., Ekkati, A.R., Schlessinger, J., Jorgensen, W.L.

(2010) J Med Chem 53: 1662-1672

Released	2010-02-23
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Basic fibroblast growth factor receptor 1 (protein)
Unique Ligands	PO4, VM1

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3KXX \| pdb_00003kxx	Download File View File

Structure of the mutant Fibroblast Growth Factor receptor 1

Bae, J.H., Boggon, T.J., Tome, F., Mandiyan, V., Lax, I., Schlessinger, J.

(2010) Proc Natl Acad Sci U S A 107: 2866-2871

Released	2010-03-02
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Homo sapiens
Macromolecule	Basic fibroblast growth factor receptor 1 (protein)

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3KY2 \| pdb_00003ky2	Download File View File

Crystal structure of Fibroblast Growth Factor Receptor 1 kinase domain

Bae, J.H., Boggon, T.J., Tome, F., Mandiyan, V., Lax, I., Schlessinger, J.

(2010) Proc Natl Acad Sci U S A 107: 2866-2871

Released	2010-03-02
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Basic fibroblast growth factor receptor 1 (protein)
Unique Ligands	SO4

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3OJV \| pdb_00003ojv	Download File View File

Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop

Beenken, A., Mohammadi, M.

(2012) J Biological Chem 287: 3067-3078

Released	2011-12-28
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Basic fibroblast growth factor receptor 1 (protein) Heparin-binding growth factor 1 (protein)
Unique branched monosaccharides	IDS, SGN, UAP

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3RHX \| pdb_00003rhx	Download File View File

Crystal structure of the catalytic domain of FGFR1 kinase in complex with ARQ 069

Eathiraj, S., Palma, R., Hirschi, M., Volckova, E., Nakuci, E., Castro, J., Chen, C.R., Chan, T.C., France, D.S., Ashwell, M.A.

(2011) J Biological Chem 286: 20677-20687

Released	2011-05-04
Method	X-RAY DIFFRACTION 2.01 Å
Organisms	Homo sapiens
Macromolecule	Basic fibroblast growth factor receptor 1 (protein)
Unique Ligands	3RH, EDO, SO4

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3TT0 \| pdb_00003tt0	Download File View File

Co-structure of Fibroblast Growth Factor Receptor 1 kinase domain with 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (BGJ398)

Bussiere, D.E., Murray, J.M., Shu, W.

(2011) J Med Chem 54: 7066-7083

Released	2012-06-13
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Basic fibroblast growth factor receptor 1 (protein)
Unique Ligands	07J, GOL, SO4

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4F63 \| pdb_00004f63	Download File View File

Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 1

Norman, R.A., Breed, J., Ogg, D.

(2012) J Med Chem 55: 5003-5012

Released	2012-06-06
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	0S7, EDO

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4F64 \| pdb_00004f64	Download File View File

Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 6

Norman, R.A., Breed, J., Ogg, D.

(2012) J Med Chem 55: 5003-5012

Released	2012-06-06
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	0S8, EDO, SO4

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4F65 \| pdb_00004f65	Download File View File

Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 8

Norman, R.A., Breed, J., Ogg, D.

(2012) J Med Chem 55: 5003-5012

Released	2012-06-06
Method	X-RAY DIFFRACTION 2.26 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	0S9, EDO, SO4

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4NK9 \| pdb_00004nk9	Download File View File

Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 1

Norman, R.A., Klein, T.

(2014) ACS Med Chem Lett 5: 166-171

Released	2013-12-18
Method	X-RAY DIFFRACTION 2.57 Å
Organisms	Homo sapiens
Macromolecule	FIBROBLAST GROWTH FACTOR RECEPTOR 1 (protein)
Unique Ligands	2K5, EDO, SO4

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4NKA \| pdb_00004nka	Download File View File

Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 2

Norman, R.A., Klein, T.

(2014) ACS Med Chem Lett 5: 166-171

Released	2013-12-18
Method	X-RAY DIFFRACTION 2.19 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	2K7, EDO, SO4

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4NKS \| pdb_00004nks	Download File View File

Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 3

Norman, R.A., Klein, T.

(2014) ACS Med Chem Lett 5: 166-171

Released	2013-12-18
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	2M2

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4RWI \| pdb_00004rwi	Download File View File

Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M), apo

Sohl, C.D., Anderson, K.S.

(2015) ACS Chem Biol 10: 1319-1329

Released	2015-04-15
Method	X-RAY DIFFRACTION 2.292 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)

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4RWJ \| pdb_00004rwj	Download File View File

Crystal Structure of FGFR1 (C488A, C584S) in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE)

Sohl, C.D., Anderson, K.S.

(2015) ACS Chem Biol 10: 1319-1329

Released	2015-04-22
Method	X-RAY DIFFRACTION 2.489 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	66T

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4RWK \| pdb_00004rwk	Download File View File

Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M) in complex with N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE (AZD4547)

Sohl, C.D., Anderson, K.S.

(2015) ACS Chem Biol 10: 1319-1329

Released	2015-04-15
Method	X-RAY DIFFRACTION 2.982 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	66T, MG

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4RWL \| pdb_00004rwl	Download File View File

Crystal structure of FGFR1 (C488A, C584C) in complex with 6-(7-((1-aminocyclopropyl) methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide (E3810)

Sohl, C.D., Anderson, K.S.

(2015) ACS Chem Biol 10: 1319-1329

Released	2015-04-15
Method	X-RAY DIFFRACTION 2.193 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	3ZC, SO4

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4WUN \| pdb_00004wun	Download File View File

Structure of FGFR1 in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE) at 1.65 angstrom

Squire, C.J., Yosaatmadja, C.J.

(2015) Acta Crystallogr D Biol Crystallogr 71: 525-533

Released	2014-11-19
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	66T

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4ZSA \| pdb_00004zsa	Download File View File

Crystal structure of FGFR1 kinase domain in complex with 7n

Liu, Q.F., Xu, Y.C.

(2015) Org Biomol Chem 13: 7643-7654

Released	2015-06-17
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	4UT

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5EW8 \| pdb_00005ew8	Download File View File

FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH JNJ-4275693

Ogg, D., Breed, J.

(2016) Oncotarget 7: 24252-24268

Released	2016-03-30
Method	X-RAY DIFFRACTION 1.63 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	5SF, SO4

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5O49 \| pdb_00005o49	Download File View File

Human FGF in complex with a covalent inhibitor

Debreczeni, J., Breed, J., Mukherjee, H., Aquila, B., Kaiser, C., Tentarelli, S., Whitty, A., Grimster, N.

(2017) Org Biomol Chem 15: 9685-9695

Released	2018-02-07
Method	X-RAY DIFFRACTION 1.91 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	9K5, SO4

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5O4A \| pdb_00005o4a	Download File View File

Human FGF in complex with a covalent inhibitor

Debreczeni, J., Breed, J., Mukherjee, H., Aquila, B., Kaiser, C., Tentarelli, S., Whitty, A., Grimster, N.

(2017) Org Biomol Chem 15: 9685-9695

Released	2018-02-07
Method	X-RAY DIFFRACTION 2.01 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	9K8, GOL, SO4

1 to 25 of 55 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

3C4F | pdb_00003c4f

3DPK | pdb_00003dpk

3GQI | pdb_00003gqi

3GQL | pdb_00003gql

3JS2 | pdb_00003js2

3KXX | pdb_00003kxx

3KY2 | pdb_00003ky2

3OJV | pdb_00003ojv

3RHX | pdb_00003rhx

3TT0 | pdb_00003tt0

4F63 | pdb_00004f63

4F64 | pdb_00004f64

4F65 | pdb_00004f65

4NK9 | pdb_00004nk9

4NKA | pdb_00004nka

4NKS | pdb_00004nks

4RWI | pdb_00004rwi

4RWJ | pdb_00004rwj

4RWK | pdb_00004rwk

4RWL | pdb_00004rwl

4WUN | pdb_00004wun

4ZSA | pdb_00004zsa

5EW8 | pdb_00005ew8

5O49 | pdb_00005o49

5O4A | pdb_00005o4a