RCSB PDB: Search

7DKL \| pdb_00007dkl	Download File View File

Crystal structure of the tandem DEP domains of DEPTOR

Weng, Z.F., Shen, X.X., Liu, Y.F.

(2021) J Mol Biology 433: 166989-166989

Released	2021-12-08
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein)

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7OWG \| pdb_00007owg	Download File View File

human DEPTOR in a complex with mutant human mTORC1 A1459P

Heimhalt, M., Berndt, A., Wagstaff, J., Anandapadamanaban, M., Perisic, O., Maslen, S., McLaughlin, S., Yu, W.-H., Masson, G.R., Boland, A., Ni, X., Yamashita, K., Murshudov, G.N., Skehel, M., Freund, S.M., Williams, R.L.

(2021) Elife 10:

Released	2021-09-08
Method	ELECTRON MICROSCOPY 4.7 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Regulatory-associated protein of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex subunit LST8 (protein)

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7PE7 \| pdb_00007pe7	Download File View File

cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement

Waelchli, M., Maier, T.

(2021) Elife 10:

Released	2021-09-15
Method	ELECTRON MICROSCOPY 3.41 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	ACE, IHP, ZN

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7PE8 \| pdb_00007pe8	Download File View File

cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer

Waelchli, M., Maier, T.

(2021) Elife 10:

Released	2021-09-08
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	ACE, IHP, ZN

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7PE9 \| pdb_00007pe9	Download File View File

cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement

Waelchli, M., Maier, T.

(2021) Elife 10:

Released	2021-09-08
Method	ELECTRON MICROSCOPY 3.7 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Rapamycin-insensitive companion of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex 2 subunit MAPKAP1 (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	ACE, IHP, ZN

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7PEA \| pdb_00007pea	Download File View File

cryo-EM structure of DEPTOR bound to human mTOR complex 1, overall refinement

Waelchli, M., Maier, T.

(2021) Elife 10:

Released	2021-09-08
Method	ELECTRON MICROSCOPY 4.07 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Regulatory-associated protein of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	IHP

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7PEB \| pdb_00007peb	Download File View File

cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer

Waelchli, M., Maier, T.

(2021) Elife 10:

Released	2021-09-08
Method	ELECTRON MICROSCOPY 3.67 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Regulatory-associated protein of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	IHP

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7PEC \| pdb_00007pec	Download File View File

cryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinement

Waelchli, M., Maier, T.

(2021) Elife 10:

Released	2021-09-08
Method	ELECTRON MICROSCOPY 4.24 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein) Regulatory-associated protein of mTOR (protein) Serine/threonine-protein kinase mTOR (protein) Target of rapamycin complex subunit LST8 (protein)
Unique Ligands	IHP

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7PED \| pdb_00007ped	Download File View File

DEPTOR DEP domain tandem (DEPt)

Waelchli, M., Jakob, R., Maier, T.

(2021) Elife 10:

Released	2021-09-08
Method	X-RAY DIFFRACTION 1.93 Å
Organisms	Homo sapiens
Macromolecule	DEP domain-containing mTOR-interacting protein (protein)

7DKL | pdb_00007dkl

Crystal structure of the tandem DEP domains of DEPTOR

7OWG | pdb_00007owg

human DEPTOR in a complex with mutant human mTORC1 A1459P

7PE7 | pdb_00007pe7

cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement

7PE8 | pdb_00007pe8

cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer

7PE9 | pdb_00007pe9

cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement

7PEA | pdb_00007pea

cryo-EM structure of DEPTOR bound to human mTOR complex 1, overall refinement

7PEB | pdb_00007peb

cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer

7PEC | pdb_00007pec

cryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinement

7PED | pdb_00007ped

DEPTOR DEP domain tandem (DEPt)

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

7DKL | pdb_00007dkl

7OWG | pdb_00007owg

7PE7 | pdb_00007pe7

7PE8 | pdb_00007pe8

7PE9 | pdb_00007pe9

7PEA | pdb_00007pea

7PEB | pdb_00007peb

7PEC | pdb_00007pec

7PED | pdb_00007ped