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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "CAR"

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Search Summary

This query matches 21 Structures.

Refinements

Structure Determination Methodology

experimental (21)

Scientific Name of Source Organism

	Homo sapiens (13)
	Coxsackievirus B3 (5)
	Mus musculus (3)
	Nocardia iowensis (3)
	Human adenovirus 12 (2)
	Mycobacterium marinum M (2)
	Coxsackievirus B3 (strain Woodruff) (1)

Taxonomy

	Eukaryota (16)
	Riboviria (6)
	Bacteria (5)
	Varidnaviria (2)

Experimental Method

	X-RAY DIFFRACTION (11)
	ELECTRON MICROSCOPY (8)
	SOLUTION NMR (2)

Polymer Entity Type

Protein (21)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (4)
	2.0 - 2.5 (2)
	2.5 - 3.0 (6)
	3.0 - 3.5 (2)
	3.5 - 4.0 (1)
	> 4.5 (3)

Release Date

	2000 - 2004 (5)
	2005 - 2009 (2)
	2010 - 2014 (4)
	2015 - 2019 (5)
	2020 - 2024 (5)

Enzyme Classification Name

	Oxidoreductases (5)
	Transferases (1)

Membrane Protein Annotation

mpstruc (1)

Symmetry Type

	Asymmetric (11)
	Icosahedral (8)
	Cyclic (3)

SCOP Classification

	All alpha proteins (2)
	All beta proteins (3)
	Low resolution protein structures (1)
	Artifacts (3)

AllSelected

1 to 21 of 21 Structures

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1JEW \| pdb_00001jew	Download File View File

CRYO-EM STRUCTURE OF COXSACKIEVIRUS B3(M STRAIN) WITH ITS CELLULAR RECEPTOR, COXSACKIEVIRUS AND ADENOVIRUS RECEPTOR (CAR).

Rossmann, M.G., He, Y.

(2001) Nat Struct Biol 8: 874-878

Released	2001-10-03
Method	ELECTRON MICROSCOPY 22 Å
Organisms	Coxsackievirus B3 (strain Woodruff) Homo sapiens
Macromolecule	COXSACKIEVIRUS AND ADENOVIRUS RECEPTOR (protein) COXSACKIEVIRUS CAPSID, COAT PROTEIN VP1 (protein) COXSACKIEVIRUS CAPSID, COAT PROTEIN VP2 (protein) COXSACKIEVIRUS CAPSID, COAT PROTEIN VP3 (protein) COXSACKIEVIRUS CAPSID, COAT PROTEIN VP4 (protein)

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1P69 \| pdb_00001p69	Download File View File

STRUCTURAL BASIS FOR VARIATION IN ADENOVIRUS AFFINITY FOR THE CELLULAR RECEPTOR CAR (P417S MUTANT)

Howitt, J., Bewley, M.C., Graziano, V., Flanagan, J.M., Freimuth, P.

(2003) J Biological Chem 278: 26208-26215

Released	2004-05-11
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens Human adenovirus 12
Macromolecule	Coxsackievirus and adenovirus receptor (protein) Fiber protein (protein)

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1P6A \| pdb_00001p6a	Download File View File

STRUCTURAL BASIS FOR VARIATION IN ADENOVIRUS AFFINITY FOR THE CELLULAR RECEPTOR CAR (S489Y MUTANT)

Howitt, J., Bewley, M.C., Graziano, V., Flanagan, J.M., Freimuth, P.

(2003) J Biological Chem 278: 26208-26215

Released	2004-05-11
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens Human adenovirus 12
Macromolecule	Coxsackievirus and adenovirus receptor (protein) Fiber protein (protein)

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1RSF \| pdb_00001rsf	Download File View File

NMR Structure of Monomeric CAR d1 domain

Jiang, S., Jacobs, A., Laue, T.M., Caffrey, M.

(2004) Biochemistry 43: 1847-1853

Released	2004-03-02
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Coxsackievirus and adenovirus receptor (protein)

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1XNX \| pdb_00001xnx	Download File View File

Crystal structure of constitutive androstane receptor

Fernandez, E.

(2004) Mol Cell 16: 907-917

Released	2005-01-04
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Mus musculus
Macromolecule	constitutive androstane receptor (protein)
Unique Ligands	ATE

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1XVP \| pdb_00001xvp	Download File View File

crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid and CITCO

Xu, R.X., Lambert, M.H., Wisely, B.B., Warren, E.N., Weinert, E.E., Waitt, G.M., Williams, J.D., Moore, L.B., Willson, T.M., Moore, J.T.

(2004) Mol Cell 16: 919-928

Released	2004-12-28
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Orphan nuclear receptor NR1I3 (protein) Retinoic acid receptor RXR-alpha (protein) nuclear receptor coactivator 1 isoform 1 (protein)
Unique Ligands	CID, F15

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2NPL \| pdb_00002npl	Download File View File

NMR Structure of CARD d2 Domain

Jiang, S., Caffrey, M.

(2007) Protein Sci 16: 539-542

Released	2007-03-13
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Coxsackievirus and Adenovirus Receptor (protein)

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3J6L \| pdb_00003j6l	Download File View File

Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle

Organtini, L.J., Makhov, A.M., Conway, J.F., Hafenstein, S., Carson, S.D.

(2014) J Virol 88: 5755-5765

Released	2014-04-09
Method	ELECTRON MICROSCOPY 9 Å
Organisms	Homo sapiens
Macromolecule	Coxsackievirus and adenovirus receptor (protein)
Unique Ligands	SO4

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3J6M \| pdb_00003j6m	Download File View File

Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle

Organtini, L.J., Makhov, A.M., Conway, J.F., Hafenstein, S., Carson, S.D.

(2014) J Virol 88: 5755-5765

Released	2014-04-09
Method	ELECTRON MICROSCOPY 9 Å
Organisms	Homo sapiens
Macromolecule	Coxsackievirus and adenovirus receptor (protein)

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3JZ7 \| pdb_00003jz7	Download File View File

Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)

Max, K.E.A., Heinemann, U.

(2010) J Neurosci 30: 2897-2910

Released	2010-03-16
Method	X-RAY DIFFRACTION 2.19 Å
Organisms	Mus musculus
Macromolecule	Coxsackievirus and adenovirus receptor homolog (protein)
Unique Ligands	IPA

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3MJ7 \| pdb_00003mj7	Download File View File

Crystal structure of the complex of JAML and Coxsackie and Adenovirus receptor, CAR

Verdino, P., Wilson, I.A.

(2010) Science 329: 1210-1214

Released	2010-09-22
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Mus musculus
Macromolecule	Coxsackievirus and adenovirus receptor homolog (protein) Junctional adhesion molecule-like (protein)
Unique Ligands	NAG
Unique branched monosaccharides	BMA, FUC, MAN, NAG

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5MSC \| pdb_00005msc	Download File View File

Structure of the A domain of carboxylic acid reductase (CAR) from Nocardia iowensis in complex with AMP

Dunstan, M.S., Leys, D.

(2017) Nat Chem Biol 13: 975-981

Released	2017-07-05
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Nocardia iowensis
Macromolecule	Carboxylic acid reductase (protein)
Unique Ligands	AMP

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5MSD \| pdb_00005msd	Download File View File

Structure of the A domain of carboxylic acid reductase (CAR) from Nocardia iowensis in complex with AMP and benzoic acid

Dunstan, M.S., Leys, D.

(2017) Nat Chem Biol 13: 975-981

Released	2017-07-05
Method	X-RAY DIFFRACTION 1.71 Å
Organisms	Nocardia iowensis
Macromolecule	Carboxylic acid reductase (protein)
Unique Ligands	AMP, BEZ

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5MSO \| pdb_00005mso	Download File View File

Structure of the R domain of carboxylic acid reductase (CAR) from Mycobacterium marinum in complex with NADP

Gahloth, D., Leys, D.

(2017) Nat Chem Biol 13: 975-981

Released	2017-07-05
Method	X-RAY DIFFRACTION 1.2 Å
Organisms	Mycobacterium marinum M
Macromolecule	Carboxylic acid reductase (protein)
Unique Ligands	NAP

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5MSQ \| pdb_00005msq	Download File View File

Structure of the A domain of carboxylic acid reductase (CAR) from Nocardia iowensis in complex with AMP and iodide

Dunstan, M.S., Leys, D.

To be published

Released	2018-01-17
Method	X-RAY DIFFRACTION 1.74 Å
Organisms	Nocardia iowensis
Macromolecule	Carboxylic acid reductase (protein)
Unique Ligands	AMP, IOD

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5MSU \| pdb_00005msu	Download File View File

Structure of the R domain of carboxylic acid reductase (CAR) from Mycobacterium marinum in complex with NADP, P21 form

Gahloth, D., Leys, D.

(2017) Nat Chem Biol 13: 975-981

Released	2017-07-05
Method	X-RAY DIFFRACTION 1.74 Å
Organisms	Mycobacterium marinum M
Macromolecule	Carboxylic acid reductase (protein)
Unique Ligands	NAP

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7VXZ \| pdb_00007vxz	Download File View File

Coxsackievirus B3 at pH7.4 (VP3-234Q) incubation with coxsackievirus and adenovirus receptor for 20min

Wang, Q.L., Liu, C.C.

(2022) Proc Natl Acad Sci U S A 119:

Released	2022-01-19
Method	ELECTRON MICROSCOPY 3.19 Å
Organisms	Coxsackievirus B3 Homo sapiens
Macromolecule	Capsid protein VP1 (protein) Capsid protein VP2 (protein) Capsid protein VP3 (protein) Capsid protein VP4 (protein) Coxsackievirus and adenovirus receptor (protein)

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7VYK \| pdb_00007vyk	Download File View File

Coxsackievirus B3 at pH7.4 (VP3-234Q) incubation with coxsackievirus and adenovirus receptor for 10min

Wang, Q.L., Liu, C.C.

(2022) Proc Natl Acad Sci U S A 119:

Released	2022-01-19
Method	ELECTRON MICROSCOPY 2.79 Å
Organisms	Coxsackievirus B3 Homo sapiens
Macromolecule	Capsid protein VP1 (protein) Capsid protein VP2 (protein) Capsid protein VP3 (protein) Capsid protein VP4 (protein) Coxsackievirus and adenovirus receptor (protein)
Unique Ligands	PLM

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7VYL \| pdb_00007vyl	Download File View File

Coxsackievirus B3 at pH5.5 (VP3-234Q) incubation with coxsackievirus and adenovirus receptor for 20min

Wang, Q.L., Liu, C.C.

(2022) Proc Natl Acad Sci U S A 119:

Released	2022-01-19
Method	ELECTRON MICROSCOPY 2.79 Å
Organisms	Coxsackievirus B3 Homo sapiens
Macromolecule	Capsid protein VP1 (protein) Capsid protein VP2 (protein) Capsid protein VP3 (protein) Capsid protein VP4 (protein) Coxsackievirus and adenovirus receptor (protein)

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7VYM \| pdb_00007vym	Download File View File

Coxsackievirus B3 at pH7.4 (VP3-234E) incubation with coxsackievirus and adenovirus receptor for 10min

Wang, Q.L., Liu, C.C.

(2022) Proc Natl Acad Sci U S A 119:

Released	2022-01-19
Method	ELECTRON MICROSCOPY 3.68 Å
Organisms	Coxsackievirus B3 Homo sapiens
Macromolecule	Capsid protein VP1 (protein) Capsid protein VP2 (protein) Capsid protein VP3 (protein) Capsid protein VP4 (protein) Coxsackievirus and adenovirus receptor (protein)

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7W14 \| pdb_00007w14	Download File View File

Coxsackievirus B3 at pH7.4 (VP3-234E) incubation with coxsackievirus and adenovirus receptor for 20min

Wang, Q.L., Liu, C.C.

(2022) Proc Natl Acad Sci U S A 119:

Released	2022-01-19
Method	ELECTRON MICROSCOPY 2.2 Å
Organisms	Coxsackievirus B3 Homo sapiens
Macromolecule	Capsid protein VP1 (protein) Capsid protein VP2 (protein) Capsid protein VP3 (protein) Capsid protein VP4 (protein) Coxsackievirus and adenovirus receptor (protein)

1 to 21 of 21 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1JEW | pdb_00001jew

1P69 | pdb_00001p69

1P6A | pdb_00001p6a

1RSF | pdb_00001rsf

1XNX | pdb_00001xnx

1XVP | pdb_00001xvp

2NPL | pdb_00002npl

3J6L | pdb_00003j6l

3J6M | pdb_00003j6m

3JZ7 | pdb_00003jz7

3MJ7 | pdb_00003mj7

5MSC | pdb_00005msc

5MSD | pdb_00005msd

5MSO | pdb_00005mso

5MSQ | pdb_00005msq

5MSU | pdb_00005msu

7VXZ | pdb_00007vxz

7VYK | pdb_00007vyk

7VYL | pdb_00007vyl

7VYM | pdb_00007vym

7W14 | pdb_00007w14