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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Chemical ID(s) = ABA

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Search Summary

This query matches 107 Polymer Entities.

Refinements

Structure Determination Methodology

experimental (107)

Scientific Name of Source Organism

	Tolypocladium inflatum (49)
	synthetic construct (29)
	Homo sapiens (4)
	Shewanella oneidensis MR-1 (4)
	Xylaria (4)
	Streptomyces sp. (3)
	Mycena rosella (2)
	Nonomuraea sp. MJM5123 (2)
	Streptomyces (2)
	Cylindrocarpon lucidum (1)

More...

Taxonomy

	Eukaryota (61)
	other sequences (29)
	Bacteria (14)
	Eukaryota (eukaryotes) (1)

Experimental Method

	X-RAY DIFFRACTION (88)
	SOLUTION NMR (16)
	ELECTRON MICROSCOPY (3)

Polymer Entity Type

Protein (107)

Refinement Resolution (Å)

	0.5 - 1.0 (7)
	1.0 - 1.5 (16)
	1.5 - 2.0 (28)
	2.0 - 2.5 (24)
	2.5 - 3.0 (10)
	3.0 - 3.5 (5)
	3.5 - 4.0 (1)

Release Date

	1990 - 1994 (4)
	1995 - 1999 (21)
	2000 - 2004 (6)
	2005 - 2009 (8)
	2010 - 2014 (15)
	2015 - 2019 (16)
	2020 - 2024 (34)
	2025 - 2029 (3)

Symmetry Type

	Asymmetric (81)
	Cyclic (15)
	Dihedral (7)
	Tetrahedral (1)

SCOP Classification

Alpha and beta proteins (a+b) (3)

AllSelected

1 to 25 of 107 Polymer Entities

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1BCK: Entity 2	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 2-THR CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-09-16
Method	X-RAY DIFFRACTION 1.8 Å
Chain ID	B [auth C]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN C

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1C5F: Entity 2	Download File View File

CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A

Ellis, P.J., Carlow, C.K.S., Ma, D., Kuhn, P.

(2000) Biochemistry 39: 592

Released	1999-12-03
Method	X-RAY DIFFRACTION 2.47 Å
Chain IDs	B, D, F, H, J
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1CSA: Entity 1	Download File View File

THE MUTANT E.COLI F112W CYCLOPHILIN BINDS CYCLOSPORIN A IN NEARLY IDENTICAL CONFORMATION AS HUMAN CYCLOPHILIN

Fejzo, J., Walsh, C.T., Wagner, G.

(1994) Biochemistry 33: 5711

Released	1994-04-30
Method	SOLUTION NMR
Chain ID	A
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1CWA: Entity 2	Download File View File

X-RAY STRUCTURE OF A MONOMERIC CYCLOPHILIN A-CYCLOSPORIN A CRYSTAL COMPLEX AT 2.1 ANGSTROMS RESOLUTION

Mikol, V., Kallen, J., Walkinshaw, M.D.

(1993) J Mol Biology 234: 1119

Released	1996-01-29
Method	X-RAY DIFFRACTION 2.1 Å
Chain ID	B [auth C]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1CWB: Entity 2	Download File View File

THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY

Mikol, V., Kallen, J., Walkinshaw, M.D.

(1994) Protein Eng 7: 597

Released	1996-01-29
Method	X-RAY DIFFRACTION 2.2 Å
Chain ID	B [auth C]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1CWC: Entity 2	Download File View File

IMPROVED BINDING AFFINITY FOR CYCLOPHILIN A BY A CYCLOSPORIN DERIVATIVE SINGLY MODIFIED AT ITS EFFECTOR DOMAIN

Mikol, V.

(1994) J Med Chem 37: 3674

Released	1996-01-29
Method	X-RAY DIFFRACTION 1.86 Å
Chain ID	B [auth C]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1CWF: Entity 2	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-07-15
Method	X-RAY DIFFRACTION 1.86 Å
Chain ID	B [auth C]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN D

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1CWH: Entity 2	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 3-D-SER CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-07-15
Method	X-RAY DIFFRACTION 1.86 Å
Chain ID	B [auth C]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1CWI: Entity 2	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-(N-METHYL)-D-ALANINE CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-08-12
Method	X-RAY DIFFRACTION 1.9 Å
Chain ID	B [auth C]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN D

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1CWJ: Entity 2	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-S-METHYL-SARCOSINE CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-08-26
Method	X-RAY DIFFRACTION 1.8 Å
Chain ID	B [auth C]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN D

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1CWK: Entity 2	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-07-15
Method	X-RAY DIFFRACTION 1.8 Å
Chain ID	B [auth C]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN D

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1CWL: Entity 2	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 4 4-HYDROXY-MELEU CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-07-15
Method	X-RAY DIFFRACTION 1.8 Å
Chain ID	B [auth C]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1CWM: Entity 2	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH 4 MEILE CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 435

Released	1998-07-15
Method	X-RAY DIFFRACTION 2 Å
Chain ID	B [auth C]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1CWO: Entity 2	Download File View File

HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

(1998) J Mol Biology 283: 451

Released	1998-08-12
Method	X-RAY DIFFRACTION 1.86 Å
Chain ID	B [auth C]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN C

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1CYA: Entity 1	Download File View File

NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING

Fesik, S.W.

(1991) Biochemistry 30: 6574

Released	1994-01-31
Method	SOLUTION NMR
Chain ID	A
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1CYB: Entity 1	Download File View File

NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING

Fesik, S.W.

(1991) Biochemistry 30: 6574

Released	1994-01-31
Method	SOLUTION NMR
Chain ID	A
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1CYN: Entity 2	Download File View File

CYCLOPHILIN B COMPLEXED WITH [D-(CHOLINYLESTER)SER8]-CYCLOSPORIN

Mikol, V., Kallen, J., Walkinshaw, M.D.

(1994) Proc Natl Acad Sci U S A 91: 5183

Released	1996-01-29
Method	X-RAY DIFFRACTION 1.85 Å
Chain ID	B [auth C]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1IKF: Entity 3	Download File View File

A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX

Vix, O., Altschuh, D., Rees, B., Thierry, J.-C.

(1992) Science 256: 92

Released	1995-03-31
Method	X-RAY DIFFRACTION 2.5 Å
Chain ID	C
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1IKL: Entity 1	Download File View File

NMR study of monomeric human interleukin-8 (minimized average structure)

Rajarathnam, K., Clark-Lewis, I., Sykes, B.D.

(1995) Biochemistry 34: 12983-12990

Released	1995-10-15
Method	SOLUTION NMR
Chain ID	A
Organism	Homo sapiens
Macromolecule	HUMAN INTERLEUKIN-8 (MONOMERIC)

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1IKM: Entity 1	Download File View File

NMR study of monomeric human interleukin-8 (30 structures)

Rajarathnam, K., Clark-Lewis, I., Sykes, B.D.

(1995) Biochemistry 34: 12983-12990

Released	1995-10-15
Method	SOLUTION NMR
Chain ID	A
Organism	Homo sapiens
Macromolecule	HUMAN INTERLEUKIN-8 (MONOMERIC)

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1LV9: Entity 1	Download File View File

CXCR3 Binding Chemokine IP-10/CXCL10

Booth, V., Keizer, D.W., Kamphuis, M.B., Clark-Lewis, I., Sykes, B.D.

(2002) Biochemistry 41: 10418-10425

Released	2002-09-18
Method	SOLUTION NMR
Chain ID	A
Organism	Homo sapiens
Macromolecule	Small inducible cytokine B10

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1M63: Entity 4	Download File View File

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

Huai, Q., Kim, H.-Y., Liu, Y., Zhao, Y., Mondragon, A., Liu, J.O., Ke, H.

(2002) Proc Natl Acad Sci U S A 99: 12037

Released	2002-09-25
Method	X-RAY DIFFRACTION 2.8 Å
Chain IDs	D, H
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1MF8: Entity 4	Download File View File

Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin

Jin, L., Harrison, S.C.

(2002) Proc Natl Acad Sci U S A 99: 13522

Released	2002-10-16
Method	X-RAY DIFFRACTION 3.1 Å
Chain ID	D
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1MIK: Entity 2	Download File View File

THE ROLE OF WATER MOLECULES IN THE STRUCTURE-BASED DESIGN OF (5-HYDROXYNORVALINE)-2-CYCLOSPORIN: SYNTHESIS, BIOLOGICAL ACTIVITY, AND CRYSTALLOGRAPHIC ANALYSIS WITH CYCLOPHILIN A

Mikol, V.

(1995) J Med Chem 38: 3361

Released	1996-03-08
Method	X-RAY DIFFRACTION 1.76 Å
Chain ID	B
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

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1QNG: Entity 2	Download File View File

Plasmodium falciparum Cyclophilin complexed with Cyclosporin A

Peterson, M.R., Hall, D.R., Hunter, W.N.

(2000) J Mol Biology 298: 123

Released	2000-10-13
Method	X-RAY DIFFRACTION 2.1 Å
Chain ID	B [auth D]
Organism	Tolypocladium inflatum
Macromolecule	CYCLOSPORIN A

1 to 25 of 107 Polymer Entities

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Structure Determination Methodology

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