RCSB PDB: Search

1ESJ \| pdb_00001esj	Download File View File

CRYSTAL STRUCTURE OF THIAZOLE KINASE MUTANT (C198S)

Campobasso, N., Mathews, I.I., Begley, T.P., Ealick, S.E.

(2000) Biochemistry 39: 7868-7877

Released	2000-08-09
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Bacillus subtilis
Macromolecule	HYDROXYETHYLTHIAZOLE KINASE (protein)
Unique Ligands	SO4

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1ESQ \| pdb_00001esq	Download File View File

CRYSTAL STRUCTURE OF THIAZOLE KINASE MUTANT (C198S) WITH ATP AND THIAZOLE PHOSPHATE.

Campobasso, N., Mathews, I.I., Begley, T.P., Ealick, S.E.

(2000) Biochemistry 39: 7868-7877

Released	2000-08-09
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Bacillus subtilis
Macromolecule	HYDROXYETHYLTHIAZOLE KINASE (protein)
Unique Ligands	ATP, MG, SO4, TZP

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2YM3 \| pdb_00002ym3	Download File View File

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Reader, J.C., Matthews, T.P., Klair, S., Cheung, K.M.J., Scanlon, J., Proisy, N., Addison, G., Ellard, J., Piton, N., Taylor, S., Cherry, M., Fisher, M., Boxall, K., Burns, S., Walton, M.I., Westwood, I.M., Hayes, A., Eve, P., Valenti, M., Brandon, A.H., Box, G., vanMontfort, R.L.M., Williams, D.H., Aherne, G.W., Raynaud, F.I., Eccles, S.A., Garrett, M.D., Collins, I.

(2011) J Med Chem 54: 8328

Released	2012-01-11
Method	X-RAY DIFFRACTION 2.007 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE CHK1 (protein)
Unique Ligands	EDO, YM3

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2YM4 \| pdb_00002ym4	Download File View File

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Reader, J.C., Matthews, T.P., Klair, S., Cheung, K.M.J., Scanlon, J., Proisy, N., Addison, G., Ellard, J., Piton, N., Taylor, S., Cherry, M., Fisher, M., Boxall, K., Burns, S., Walton, M.I., Westwood, I.M., Hayes, A., Eve, P., Valenti, M., Brandon, A.H., Box, G., vanMontfort, R.L.M., Williams, D.H., Aherne, G.W., Raynaud, F.I., Eccles, S.A., Garrett, M.D., Collins, I.

(2011) J Med Chem 54: 8328

Released	2012-01-11
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE CHK1 (protein)
Unique Ligands	4YM, EDO

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2YM5 \| pdb_00002ym5	Download File View File

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Reader, J.C., Matthews, T.P., Klair, S., Cheung, K.M.J., Scanlon, J., Proisy, N., Addison, G., Ellard, J., Piton, N., Taylor, S., Cherry, M., Fisher, M., Boxall, K., Burns, S., Walton, M.I., Westwood, I.M., Hayes, A., Eve, P., Valenti, M., Brandon, A.H., Box, G., vanMontfort, R.L.M., Williams, D.H., Aherne, G.W., Raynaud, F.I., Eccles, S.A., Garrett, M.D., Collins, I.

(2011) J Med Chem 54: 8328

Released	2012-01-11
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE CHK1 (protein)
Unique Ligands	EDO, YM5

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2YM6 \| pdb_00002ym6	Download File View File

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Reader, J.C., Matthews, T.P., Klair, S., Cheung, K.M.J., Scanlon, J., Proisy, N., Addison, G., Ellard, J., Piton, N., Taylor, S., Cherry, M., Fisher, M., Boxall, K., Burns, S., Walton, M.I., Westwood, I.M., Hayes, A., Eve, P., Valenti, M., Brandon, A.H., Box, G., vanMontfort, R.L.M., Williams, D.H., Aherne, G.W., Raynaud, F.I., Eccles, S.A., Garrett, M.D., Collins, I.

(2011) J Med Chem 54: 8328

Released	2012-01-11
Method	X-RAY DIFFRACTION 2.01 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE CHK1 (protein)
Unique Ligands	EDO, YM6

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2YM7 \| pdb_00002ym7	Download File View File

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Reader, J.C., Matthews, T.P., Klair, S., Cheung, K.M.J., Scanlon, J., Proisy, N., Addison, G., Ellard, J., Piton, N., Taylor, S., Cherry, M., Fisher, M., Boxall, K., Burns, S., Walton, M.I., Westwood, I.M., Hayes, A., Eve, P., Valenti, M., Brandon, A.H., Box, G., vanMontfort, R.L.M., Williams, D.H., Aherne, G.W., Raynaud, F.I., Eccles, S.A., Garrett, M.D., Collins, I.

(2011) J Med Chem 54: 8328

Released	2012-01-11
Method	X-RAY DIFFRACTION 1.81 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE CHK1 (protein)
Unique Ligands	EDO, YM7

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2YM8 \| pdb_00002ym8	Download File View File

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Reader, J.C., Matthews, T.P., Klair, S., Cheung, K.M.J., Scanlon, J., Proisy, N., Addison, G., Ellard, J., Piton, N., Taylor, S., Cherry, M., Fisher, M., Boxall, K., Burns, S., Walton, M.I., Westwood, I.M., Hayes, A., Eve, P., Valenti, M., Brandon, A.H., Box, G., vanMontfort, R.L.M., Williams, D.H., Aherne, G.W., Raynaud, F.I., Eccles, S.A., Garrett, M.D., Collins, I.

(2011) J Med Chem 54: 8328

Released	2012-01-11
Method	X-RAY DIFFRACTION 2.07 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE CHK1 (protein)
Unique Ligands	EDO, YM8

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3BYV \| pdb_00003byv	Download File View File

Crystal structure of Toxoplasma gondii specific rhoptry antigen kinase domain

Wernimont, A.K., Lunin, V.V., Yang, C., Lew, J., Kozieradzki, I., Lin, Y.H., Sun, X., Khuu, C., Zhao, Y., Schapira, M., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bochkarev, A., Hui, R., Sibley, D., Qiu, W., Structural Genomics Consortium (SGC)

(2009) EMBO J 28: 969-979

Released	2008-01-29
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Toxoplasma gondii
Macromolecule	Rhoptry kinase (protein)
Unique Ligands	EDO, MG

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3DZO \| pdb_00003dzo	Download File View File

Crystal structure of a rhoptry kinase from toxoplasma gondii

Wernimont, A.K., Lam, A., Ali, A., Lin, Y.H., Ni, S., Ravichandran, M., Wasney, G., Vedadi, M., Kozieradzki, I., Schapira, M., Bochkarev, A., Wilkstrom, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Sibley, D., Hui, R., Qiu, W., Structural Genomics Consortium (SGC)

(2009) EMBO J 28: 969-979

Released	2008-09-16
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Toxoplasma gondii
Macromolecule	Rhoptry kinase domain (protein)
Unique Ligands	MG

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3OKH \| pdb_00003okh	Download File View File

Crystal structure of human FXR in complex with 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid

Rudolph, M.G.

(2010) Bioorg Med Chem Lett 21: 191-194

Released	2010-12-29
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Bile acid receptor (protein) peptide of Nuclear receptor coactivator 1 (protein)
Unique Ligands	OKH

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3OKI \| pdb_00003oki	Download File View File

Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide

Rudolph, M.G.

(2010) Bioorg Med Chem Lett 21: 191-194

Released	2010-12-29
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Bile acid receptor (protein) peptide of Nuclear receptor coactivator 1 (protein)
Unique Ligands	OKI

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3OLF \| pdb_00003olf	Download File View File

Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-methylbenzoic acid

Rudolph, M.G.

(2011) Bioorg Med Chem Lett 21: 1134-1140

Released	2011-01-19
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Bile acid receptor (protein) peptide of Nuclear receptor coactivator 1 (protein)
Unique Ligands	OLF

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3OMK \| pdb_00003omk	Download File View File

Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexyl-N-(2-methylphenyl)ethanamide

Rudolph, M.G.

(2011) Bioorg Med Chem Lett 21: 1134-1140

Released	2011-01-19
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Bile acid receptor (protein) peptide of Nuclear receptor coactivator 1 (protein)
Unique Ligands	OMK

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3OMM \| pdb_00003omm	Download File View File

Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-fluorobenzoic acid

Rudolph, M.G.

(2011) Bioorg Med Chem Lett 21: 1134-1140

Released	2011-01-19
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Bile acid receptor (protein) peptide of Nuclear receptor coactivator 1 (protein)
Unique Ligands	OMM

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3OOF \| pdb_00003oof	Download File View File

Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)benzoic acid

Rudolph, M.G.

(2011) Bioorg Med Chem Lett 21: 1134-1140

Released	2011-01-19
Method	X-RAY DIFFRACTION 2.29 Å
Organisms	Homo sapiens
Macromolecule	Bile acid receptor (protein) peptide of Nuclear receptor coactivator 1 (protein)
Unique Ligands	OOF

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3OOK \| pdb_00003ook	Download File View File

Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3,5-difluorobenzoic acid

Rudolph, M.G.

(2011) Bioorg Med Chem Lett 21: 1134-1140

Released	2011-01-19
Method	X-RAY DIFFRACTION 2.29 Å
Organisms	Homo sapiens
Macromolecule	Bile acid receptor (protein) peptide of Nuclear receptor coactivator 1 (protein)
Unique Ligands	OOK

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4DH1 \| pdb_00004dh1	Download File View File

Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with low Mg2+, ATP and IP20

Kovalevsky, A.Y., Langan, P.

(2012) Acta Crystallogr D Biol Crystallogr 68: 854-860

Released	2012-06-27
Method	X-RAY DIFFRACTION 2 Å
Organisms	Mus musculus
Macromolecule	cAMP-dependent protein kinase catalytic subunit alpha (protein) cAMP-dependent protein kinase inhibitor alpha (protein)
Unique Ligands	ATP, MG

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4DH3 \| pdb_00004dh3	Download File View File

Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, ATP and IP20

Kovalevsky, A.Y., Langan, P.

(2012) Acta Crystallogr D Biol Crystallogr 68: 854-860

Released	2012-06-27
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Mus musculus
Macromolecule	cAMP-dependent protein kinase catalytic subunit alpha (protein) cAMP-dependent protein kinase inhibitor alpha (protein)
Unique Ligands	ATP, MG

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4DH5 \| pdb_00004dh5	Download File View File

Room temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, ADP, Phosphate, and IP20

Kovalevsky, A.Y., Langan, P.

(2012) Acta Crystallogr D Biol Crystallogr 68: 854-860

Released	2012-06-27
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Mus musculus
Macromolecule	cAMP-dependent protein kinase catalytic subunit alpha (protein) cAMP-dependent protein kinase inhibitor alpha (protein)
Unique Ligands	ADP, MG, PO4

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4DH7 \| pdb_00004dh7	Download File View File

Low temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, AMP-PNP and IP20'

Kovalevsky, A.Y., Langan, P.

(2012) Acta Crystallogr D Biol Crystallogr 68: 854-860

Released	2012-06-27
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Mus musculus
Macromolecule	cAMP-dependent protein kinase catalytic subunit alpha (protein) cAMP-dependent protein kinase inhibitor alpha (protein)
Unique Ligands	ANP, MG

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4DH8 \| pdb_00004dh8	Download File View File

Room temperature X-ray structure of cAMP dependent Protein Kinase A catalytic subunit with high Mg2+, AMP-PNP and IP20

Kovalevsky, A.Y., Langan, P.

(2012) Acta Crystallogr D Biol Crystallogr 68: 854-860

Released	2012-06-27
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Mus musculus
Macromolecule	cAMP-dependent protein kinase catalytic subunit alpha (protein) cAMP-dependent protein kinase inhibitor alpha (protein)
Unique Ligands	ANP, MG

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4IAC \| pdb_00004iac	Download File View File

X-RAY structure of cAMP dependent protein kinase A in complex with HIGH MG2+ concentration, AMP-PCP AND pseudo-substrate peptide SP20

Gerlits, O., Kovalevsky, A.

(2013) Biochemistry 52: 3721-3727

Released	2013-06-12
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Peptide SP20 (protein) cAMP-dependent protein kinase catalytic subunit alpha (protein)
Unique Ligands	ACP, MG

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4IAD \| pdb_00004iad	Download File View File

Low temperature X-ray Structure OF cAMP dependent protein kinase A in complex with high Mg2+ concentration, ADP and phosphorylated peptide pSP20

Gerlits, O., Kovalevsky, A.

(2013) Biochemistry 52: 3721-3727

Released	2013-06-12
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Phosphorylated peptide pSP20 (protein) cAMP-dependent protein kinase catalytic subunit alpha (protein)
Unique Ligands	ADP, MG

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4IAF \| pdb_00004iaf	Download File View File

Room temperature X-ray Structure OF cAMP dependent protein kinase A in complex with high Mg2+ concentration, ADP and phosphorylated peptide pSP20

Gerlits, O., Kovalevsky, A.

(2013) Biochemistry 52: 3721-3727

Released	2013-06-12
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	cAMP-dependent protein kinase catalytic subunit alpha (protein) phosphorylated pseudo-substrate peptide pSP20 (protein)
Unique Ligands	ADP, MG

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1ESJ | pdb_00001esj

1ESQ | pdb_00001esq

2YM3 | pdb_00002ym3

2YM4 | pdb_00002ym4

2YM5 | pdb_00002ym5

2YM6 | pdb_00002ym6

2YM7 | pdb_00002ym7

2YM8 | pdb_00002ym8

3BYV | pdb_00003byv

3DZO | pdb_00003dzo

3OKH | pdb_00003okh

3OKI | pdb_00003oki

3OLF | pdb_00003olf

3OMK | pdb_00003omk

3OMM | pdb_00003omm

3OOF | pdb_00003oof

3OOK | pdb_00003ook

4DH1 | pdb_00004dh1

4DH3 | pdb_00004dh3

4DH5 | pdb_00004dh5

4DH7 | pdb_00004dh7

4DH8 | pdb_00004dh8

4IAC | pdb_00004iac

4IAD | pdb_00004iad

4IAF | pdb_00004iaf