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233,249 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Sabatini, D.M."

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Search Summary

This query matches 12 Structures.

Refinements

Structure Determination Methodology

experimental (12)

Scientific Name of Source Organism

Homo sapiens (12)

Taxonomy

Eukaryota (12)

Experimental Method

	ELECTRON MICROSCOPY (7)
	X-RAY DIFFRACTION (5)

Polymer Entity Type

Protein (12)

Refinement Resolution (Å)

	1.5 - 2.0 (1)
	2.5 - 3.0 (3)
	3.0 - 3.5 (3)
	3.5 - 4.0 (1)
	4.0 - 4.5 (2)
	> 4.5 (2)

Release Date

	2015 - 2019 (11)
	2020 - 2024 (1)

Enzyme Classification Name

	Hydrolases (7)
	Transferases (3)
	Oxidoreductases (2)

Membrane Protein Annotation

mpstruc (1)

Symmetry Type

	Asymmetric (8)
	Cyclic (5)

SCOP Classification

Alpha and beta proteins (a+b) (1)

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1 to 12 of 12 Structures

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5DJ4 \| pdb_00005dj4	Download File View File

Leucine-bound Sestrin2 from Homo sapiens

Saxton, R.A., Knockenhauer, K.E., Schwartz, T.U.

(2016) Science 351: 53-58

Released	2015-11-25
Method	X-RAY DIFFRACTION 2.697 Å
Organisms	Homo sapiens
Macromolecule	Sestrin-2 (protein)
Unique Ligands	LEU

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5I2C \| pdb_00005i2c	Download File View File

Arginine-bound CASTOR1 from Homo sapiens

Saxton, R.A., Knockenhauer, K.E., Schwartz, T.U.

(2016) Nature 536: 229-233

Released	2016-08-10
Method	X-RAY DIFFRACTION 1.801 Å
Organisms	Homo sapiens
Macromolecule	GATS-like protein 3 (protein)
Unique Ligands	ACT, ARG

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5T0N \| pdb_00005t0n	Download File View File

Pseudo-apo structure of Sestrin2 at 3.0 angstrom resolution

Saxton, R.A., Knockenhauer, K.E., Schwartz, T.U.

(2016) Sci Signal 9: ra92-ra92

Released	2016-10-05
Method	X-RAY DIFFRACTION 3.004 Å
Organisms	Homo sapiens
Macromolecule	Sestrin-2 (protein)
Unique Ligands	LEU

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6CES \| pdb_00006ces	Download File View File

Cryo-EM structure of GATOR1-RAG

Shen, K., Huang, R.K., Brignole, E.J., Yu, Z., Sabatini, D.M.

(2018) Nature 556: 64-69

Released	2018-03-28
Method	ELECTRON MICROSCOPY 4 Å
Organisms	Homo sapiens
Macromolecule	GATOR complex protein DEPDC5 (protein) GATOR complex protein NPRL2 (protein) GATOR complex protein NPRL3 (protein) Ras-related GTP-binding protein A (protein) Ras-related GTP-binding protein C (protein)
Unique Ligands	GNP

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6CET \| pdb_00006cet	Download File View File

Cryo-EM structure of GATOR1

Shen, K., Huang, R.K., Brignole, E.J., Yu, Z., Sabatini, D.M.

(2018) Nature 556: 64-69

Released	2018-03-28
Method	ELECTRON MICROSCOPY 4.4 Å
Organisms	Homo sapiens
Macromolecule	GATOR complex protein DEPDC5 (protein) GATOR complex protein NPRL2 (protein) GATOR complex protein NPRL3 (protein)

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6S6A \| pdb_00006s6a	Download File View File

Crystal structure of RagA-Q66L/RagC-T90N GTPase heterodimer complex

Anandapadamanaban, M., Masson, G.R., Perisic, O., Kaufman, J., Williams, R.L.

(2019) Science 366: 203-210

Released	2019-10-16
Method	X-RAY DIFFRACTION 2.63 Å
Organisms	Homo sapiens
Macromolecule	Ras-related GTP-binding protein A (protein) Ras-related GTP-binding protein C (protein)
Unique Ligands	9JE, GDP, GTP, MG

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6S6D \| pdb_00006s6d	Download File View File

Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex

Anandapadamanaban, M., Masson, G.R., Perisic, O., Kaufman, J., Williams, R.L.

(2019) Science 366: 203-210

Released	2019-10-16
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Ras-related GTP-binding protein A (protein) Ras-related GTP-binding protein C (protein)
Unique Ligands	9JE, GDP, GTP, MG

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6SB0 \| pdb_00006sb0	Download File View File

cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases

Anandapadamanaban, M., Berndt, A., Masson, G.R., Perisic, O., Williams, R.L.

(2019) Science 366: 203-210

Released	2019-10-16
Method	ELECTRON MICROSCOPY 5.5 Å
Organisms	Homo sapiens
Macromolecule	Unique protein chains: 6
Unique Ligands	GDP, GTP

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6SB2 \| pdb_00006sb2	Download File View File

cryo-EM structure of mTORC1 bound to active RagA/C GTPases

Anandapadamanaban, M., Berndt, A., Masson, G.R., Perisic, O., Williams, R.L.

(2019) Science 366: 203-210

Released	2019-10-16
Method	ELECTRON MICROSCOPY 6.2 Å
Organisms	Homo sapiens
Macromolecule	Ras-related GTP-binding protein A (protein) Ras-related GTP-binding protein C (protein) Regulatory-associated protein of mTOR (protein) Target of rapamycin complex subunit LST8 (protein) mTOR,Serine/threonine-protein kinase mTOR,mTOR,Serine/threonine-protein kinase mTOR (protein)
Unique Ligands	GDP, GTP