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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Lavens, A."

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Search Summary

This query matches 37 Structures.

Refinements

Structure Determination Methodology

experimental (37)

Scientific Name of Source Organism

	Homo sapiens (17)
	Escherichia coli K-12 (9)
	Bos taurus (3)
	Mus musculus (3)
	Phage 434 (2)
	Rattus norvegicus (2)
	Saccharomyces cerevisiae (1)

Taxonomy

	Eukaryota (26)
	Bacteria (9)
	Duplodnaviria (2)

Experimental Method

	X-RAY DIFFRACTION (26)
	SOLUTION NMR (10)
	ELECTRON MICROSCOPY (1)

Polymer Entity Type

	Protein (37)
	DNA (1)

Refinement Resolution (Å)

	1.0 - 1.5 (4)
	1.5 - 2.0 (9)
	2.0 - 2.5 (13)
	3.0 - 3.5 (1)

Release Date

	1995 - 1999 (6)
	2000 - 2004 (4)
	2005 - 2009 (2)
	2010 - 2014 (13)
	2015 - 2019 (11)
	2020 - 2024 (1)

Enzyme Classification Name

	Transferases (14)
	Hydrolases (12)
	Translocases (2)

Symmetry Type

	Asymmetric (34)
	Cyclic (2)
	Dihedral (1)

SCOP Classification

	All alpha proteins (13)
	Multi-domain proteins (alpha and beta) (9)
	Alpha and beta proteins (a+b) (11)
	All beta proteins (1)
	Alpha and beta proteins (a/b) (2)

AllSelected

1 to 25 of 37 Structures

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1B64 \| pdb_00001b64	Download File View File

SOLUTION STRUCTURE OF THE GUANINE NUCLEOTIDE EXCHANGE FACTOR DOMAIN FROM HUMAN ELONGATION FACTOR-ONE BETA, NMR, 20 STRUCTURES

Perez, J.M.J., Siegal, G., Kriek, J., Hard, K., Dijk, J., Canters, G.W., Moller, W.

(1999) Structure 7: 217-226

Released	1999-05-18
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	ELONGATION FACTOR 1-BETA (protein)

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1BFI \| pdb_00001bfi	Download File View File

SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, 30 STRUCTURES

Siegal, G., Davis, B., Kristensen, S.M., Sankar, A., Linacre, J., Stein, R.C., Panayotou, G., Waterfield, M.D., Driscoll, P.C.

(1998) J Mol Biology 276: 461-478

Released	1998-02-25
Method	SOLUTION NMR
Organisms	Bos taurus
Macromolecule	P85 ALPHA (protein)

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1BFJ \| pdb_00001bfj	Download File View File

SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, MINIMIZED AVERAGE STRUCTURE

Siegal, G., Davis, B., Kristensen, S.M., Sankar, A., Linacre, J., Stein, R.C., Panayotou, G., Waterfield, M.D., Driscoll, P.C.

(1998) J Mol Biology 276: 461-478

Released	1998-02-25
Method	SOLUTION NMR
Organisms	Bos taurus
Macromolecule	P85 ALPHA (protein)

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1F60 \| pdb_00001f60	Download File View File

CRYSTAL STRUCTURE OF THE YEAST ELONGATION FACTOR COMPLEX EEF1A:EEF1BA

Andersen, G.R., Pedersen, L., Valente, L., Kinzy, T.G., Nyborg, J.

(2000) Mol Cell 6: 1261-1266

Released	2000-07-04
Method	X-RAY DIFFRACTION 1.67 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	ELONGATION FACTOR EEF1A (protein) ELONGATION FACTOR EEF1BA (protein)

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1MO7 \| pdb_00001mo7	Download File View File

ATPase

Hilge, M., Siegal, G., Vuister, G.W., Guentert, P., Gloor, S.M., Abrahams, J.P.

(2003) Nat Struct Biol 10: 468-474

Released	2003-06-03
Method	SOLUTION NMR
Organisms	Rattus norvegicus
Macromolecule	Sodium/Potassium-transporting ATPase alpha-1 chain (protein)

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1MO8 \| pdb_00001mo8	Download File View File

ATPase

Hilge, M., Siegal, G., Vuister, G.W., Guentert, P., Gloor, S.M., Abrahams, J.P.

(2003) Nat Struct Biol 10: 468-474

Released	2003-06-10
Method	SOLUTION NMR
Organisms	Rattus norvegicus
Macromolecule	Sodium/Potassium-Transporting ATPase alpha-1 (protein)
Unique Ligands	ATP

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1PBU \| pdb_00001pbu	Download File View File

Solution structure of the C-terminal domain of the human eEF1Bgamma subunit

Vanwetswinkel, S., Kriek, J., Andersen, G.R., Guntert, P., Dijk, J., Canters, G.W., Siegal, G.

(2003) J Biomol NMR 26: 189-190

Released	2003-07-15
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Elongation factor 1-gamma (protein)

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1QAD \| pdb_00001qad	Download File View File

Crystal Structure of the C-Terminal SH2 Domain of the P85 alpha Regulatory Subunit of Phosphoinositide 3-Kinase: An SH2 domain mimicking its own substrate

Hoedemaeker, P.J., Siegal, G., Roe, M., Driscoll, P.C., Abrahams, J.P.A.

(1999) J Mol Biology 292: 763-770

Released	1999-10-27
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Bos taurus
Macromolecule	PI3-KINASE P85 ALPHA SUBUNIT (protein)

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1R63 \| pdb_00001r63	Download File View File

STRUCTURAL ROLE OF A BURIED SALT BRIDGE IN THE 434 REPRESSOR DNA-BINDING DOMAIN, NMR, 20 STRUCTURES

Pervushin, K.V., Billeter, M., Siegal, G., Wuthrich, K.

(1996) J Mol Biology 264: 1002-1012

Released	1997-06-16
Method	SOLUTION NMR
Organisms	Phage 434
Macromolecule	REPRESSOR PROTEIN FROM BACTERIOPHAGE 434 (protein)

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2K6G \| pdb_00002k6g	Download File View File

Solution structure of the DNA binding BRCT domain from the large subunit of human Replication Factor C

Kobayashi, M., Siegal, G., Ab, E., Bonvin, A.M.J.J.

To be published

Released	2009-09-22
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Replication factor C subunit 1 (protein)

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2K7F \| pdb_00002k7f	Download File View File

HADDOCK calculated model of the complex between the BRCT region of RFC p140 and dsDNA

Kobayashi, M., Ab, E., Bonvin, A., Siegal, G.

(2010) J Biological Chem 285: 10087-10097

Released	2009-09-08
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Replication factor C subunit 1 (protein) 5'-D(PDCPDGPDAPDCPDCPDTPDCPDGPDAPDGPDAPDTPDCPDA)-3' (nucleic acid) 5'-D(PDCPDTPDCPDGPDAPDGPDGPDTPDCPDG)-3' (nucleic acid)

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2R63 \| pdb_00002r63	Download File View File

STRUCTURAL ROLE OF A BURIED SALT BRIDGE IN THE 434 REPRESSOR DNA-BINDING DOMAIN, NMR, 20 STRUCTURES

Pervushin, K.V., Billeter, M., Siegal, G., Wuthrich, K.

(1996) J Mol Biology 264: 1002-1012

Released	1997-06-16
Method	SOLUTION NMR
Organisms	Phage 434
Macromolecule	REPRESSOR PROTEIN FROM BACTERIOPHAGE 434 (protein)

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2XYU \| pdb_00002xyu	Download File View File

Crystal structure of EphA4 kinase domain in complex with VUF 12058

Farenc, C.J.A., Celie, P.H.N., vanLinden, O.P.J., Siegal, G.

(2012) Eur J Med Chem 47: 493

Released	2011-11-30
Method	X-RAY DIFFRACTION 2.117 Å
Organisms	Mus musculus
Macromolecule	EPHRIN TYPE-A RECEPTOR 4, (protein)
Unique Ligands	GOL, Q9G

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2Y6M \| pdb_00002y6m	Download File View File

Crystal structure of EphA4 kinase domain

Farenc, C.J.A., Celie, P.H.N., Siegal, G.

(2011) FEBS Lett 585: 3593

Released	2011-11-02
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Mus musculus
Macromolecule	EPHRIN TYPE-A RECEPTOR 4 (protein)
Unique Ligands	GOL

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2Y6O \| pdb_00002y6o	Download File View File

Crystal structure of EphA4 kinase domain in complex with Dasatinib.

Farenc, C.J.A., Celie, P.H.N., Siegal, G.

(2011) FEBS Lett 585: 3593

Released	2011-11-02
Method	X-RAY DIFFRACTION 1.543 Å
Organisms	Mus musculus
Macromolecule	EPHRIN TYPE-A RECEPTOR 4 (protein)
Unique Ligands	1N1

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4KLZ \| pdb_00004klz	Download File View File

Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis

Shah, D.M., Kobayashi, M., Keizers, P.H., Tuin, A.W., Ab, E., Manning, L., Rzepiela, A.A., Andrews, M., Hoedemaeker, F.J., Siegal, G.

To be published

Released	2014-09-17
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	GTP-binding protein Rit1 (protein)
Unique Ligands	GDP, MG

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4KZ3 \| pdb_00004kz3	Download File View File

Crystal structure of AmpC beta-lactamase in complex with fragment 44 (5-chloro-3-sulfamoylthiophene-2-carboxylic acid)

Eidam, O., Barelier, S., Fish, I., Shoichet, B.K.

(2014) ACS Chem Biol 9: 1528-1535

Released	2014-05-21
Method	X-RAY DIFFRACTION 1.67 Å
Organisms	Escherichia coli K-12
Macromolecule	Beta-lactamase (protein)
Unique Ligands	1U1, PO4

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4KZ4 \| pdb_00004kz4	Download File View File

Crystal structure of AmpC beta-lactamase in complex with fragment 60 (2-[(propylsulfonyl)amino]benzoic acid)

Eidam, O., Barelier, S., Fish, I., Shoichet, B.K.

(2014) ACS Chem Biol 9: 1528-1535

Released	2014-05-21
Method	X-RAY DIFFRACTION 1.42 Å
Organisms	Escherichia coli K-12
Macromolecule	Beta-lactamase (protein)
Unique Ligands	4A1, PO4

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4KZ5 \| pdb_00004kz5	Download File View File

Crystal structure of AmpC beta-lactamase in complex with fragment 5 (N-{[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}glycine)

Eidam, O., Barelier, S., Fish, I., Shoichet, B.K.

(2014) ACS Chem Biol 9: 1528-1535

Released	2014-05-21
Method	X-RAY DIFFRACTION 1.35 Å
Organisms	Escherichia coli K-12
Macromolecule	Beta-lactamase (protein)
Unique Ligands	1U3, PO4

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4KZ6 \| pdb_00004kz6	Download File View File

Crystal structure of AmpC beta-lactamase in complex with fragment 13 ((2R,6R)-6-methyl-1-(3-sulfanylpropanoyl)piperidine-2-carboxylic acid)

Eidam, O., Barelier, S., Fish, I., Shoichet, B.K.

(2014) ACS Chem Biol 9: 1528-1535

Released	2014-05-21
Method	X-RAY DIFFRACTION 1.68 Å
Organisms	Escherichia coli K-12
Macromolecule	Beta-lactamase (protein)
Unique Ligands	PO4, ZB6

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4KZ7 \| pdb_00004kz7	Download File View File

Crystal structure of AmpC beta-lactamase in complex with fragment 16 ((1R,4S)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid)

Eidam, O., Barelier, S., Fish, I., Shoichet, B.K.

(2014) ACS Chem Biol 9: 1528-1535

Released	2014-05-21
Method	X-RAY DIFFRACTION 1.43 Å
Organisms	Escherichia coli K-12
Macromolecule	Beta-lactamase (protein)
Unique Ligands	1U5, PO4

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4KZ8 \| pdb_00004kz8	Download File View File

Crystal structure of AmpC beta-lactamase in complex with fragment 20 (1,3-diethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione)

Eidam, O., Barelier, S., Fish, I., Shoichet, B.K.

(2014) ACS Chem Biol 9: 1528-1535

Released	2014-05-21
Method	X-RAY DIFFRACTION 2.282 Å
Organisms	Escherichia coli K-12
Macromolecule	Beta-lactamase (protein)
Unique Ligands	1U6, PO4

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4KZ9 \| pdb_00004kz9	Download File View File

Crystal structure of AmpC beta-lactamase in complex with fragment 41 ((4R,4aS,8aS)-4-phenyldecahydroquinolin-4-ol)

Eidam, O., Barelier, S., Fish, I., Shoichet, B.K.

(2014) ACS Chem Biol 9: 1528-1535

Released	2014-05-21
Method	X-RAY DIFFRACTION 1.72 Å
Organisms	Escherichia coli K-12
Macromolecule	Beta-lactamase (protein)
Unique Ligands	1U7, PO4

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4KZA \| pdb_00004kza	Download File View File

Crystal structure of AmpC beta-lactamase in complex with fragment 48 (3-(cyclopropylsulfamoyl)thiophene-2-carboxylic acid)

Eidam, O., Barelier, S., Fish, I., Shoichet, B.K.

(2014) ACS Chem Biol 9: 1528-1535

Released	2014-05-21
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Escherichia coli K-12
Macromolecule	Beta-lactamase (protein)
Unique Ligands	NZ9, PO4

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4KZB \| pdb_00004kzb	Download File View File

Crystal structure of AmpC beta-lactamase in complex with fragment 50 (N-(methylsulfonyl)-N-phenyl-alanine)

Eidam, O., Barelier, S., Fish, I., Shoichet, B.K.

(2014) ACS Chem Biol 9: 1528-1535

Released	2014-05-21
Method	X-RAY DIFFRACTION 1.37 Å
Organisms	Escherichia coli K-12
Macromolecule	Beta-lactamase (protein)
Unique Ligands	NZ2, NZ3

1 to 25 of 37 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1B64 | pdb_00001b64

1BFI | pdb_00001bfi

1BFJ | pdb_00001bfj

1F60 | pdb_00001f60

1MO7 | pdb_00001mo7

1MO8 | pdb_00001mo8

1PBU | pdb_00001pbu

1QAD | pdb_00001qad

1R63 | pdb_00001r63

2K6G | pdb_00002k6g

2K7F | pdb_00002k7f

2R63 | pdb_00002r63

2XYU | pdb_00002xyu

2Y6M | pdb_00002y6m

2Y6O | pdb_00002y6o

4KLZ | pdb_00004klz

4KZ3 | pdb_00004kz3

4KZ4 | pdb_00004kz4

4KZ5 | pdb_00004kz5

4KZ6 | pdb_00004kz6

4KZ7 | pdb_00004kz7

4KZ8 | pdb_00004kz8

4KZ9 | pdb_00004kz9

4KZA | pdb_00004kza

4KZB | pdb_00004kzb