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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Cobb, M.H."

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Search Summary

This query matches 23 Structures.

Refinements

Structure Determination Methodology

experimental (23)

Scientific Name of Source Organism

	Rattus norvegicus (11)
	Homo sapiens (8)
	Mus musculus (5)

Taxonomy

	Eukaryota (23)
	Eukaryota (eukaryotes) (1)

Experimental Method

X-RAY DIFFRACTION (23)

Polymer Entity Type

Protein (23)

Refinement Resolution (Å)

	1.5 - 2.0 (3)
	2.0 - 2.5 (13)
	2.5 - 3.0 (5)
	3.0 - 3.5 (1)
	3.5 - 4.0 (1)

Release Date

	1995 - 1999 (8)
	2000 - 2004 (4)
	2005 - 2009 (2)
	2010 - 2014 (2)
	2015 - 2019 (7)

Enzyme Classification Name

Transferases (23)

Symmetry Type

	Asymmetric (19)
	Cyclic (6)

SCOP Classification

	Alpha and beta proteins (a+b) (22)
	Artifacts (1)

AllSelected

1 to 23 of 23 Structures

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1A9U \| pdb_00001a9u	Download File View File

THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580

Wang, Z., Canagarajah, B., Boehm, J.C., Kassis, S., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.

(1998) Structure 6: 1117-1128

Released	1999-04-20
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	MAP KINASE P38 (protein)
Unique Ligands	SB2

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1BL6 \| pdb_00001bl6	Download File View File

THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB216995

Wang, Z., Canagarajah, B.J., Boehm, J.C., Kassis, S., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.

(1998) Structure 6: 1117-1128

Released	1999-07-26
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (MAP KINASE P38) (protein)
Unique Ligands	SB6

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1BL7 \| pdb_00001bl7	Download File View File

THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB220025

Wang, Z., Canagarajah, B.J., Boehm, J.C., Kassis, S., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.

(1998) Structure 6: 1117-1128

Released	1999-07-26
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (MAP KINASE P38) (protein)
Unique Ligands	SB4

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1BMK \| pdb_00001bmk	Download File View File

THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655

Wang, Z., Canagarajah, B., Boehm, J.C., Kassis, S., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.

(1998) Structure 6: 1117-1128

Released	1999-07-23
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (MAP KINASE P38) (protein)
Unique Ligands	SB5

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1GOL \| pdb_00001gol	Download File View File

COORDINATES OF RAT MAP KINASE ERK2 WITH AN ARGININE MUTATION AT POSITION 52

Harkins, P.C., Zhang, F., Goldsmith, E.J.

(1996) Biochemistry 35: 5641-5646

Released	1997-03-12
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Rattus norvegicus
Macromolecule	EXTRACELLULAR REGULATED KINASE 2 (protein)
Unique Ligands	ATP, MG

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1LEW \| pdb_00001lew	Download File View File

CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A

Chang, C.-I., Xu, B.-E., Akella, R., Cobb, M.H., Goldsmith, E.J.

(2002) Mol Cell 9: 1241-1249

Released	2002-07-10
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Mitogen-activated protein kinase 14 (protein) Myocyte-specific enhancer factor 2A (protein)

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1LEZ \| pdb_00001lez	Download File View File

CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS ACTIVATOR MKK3B

Chang, C.-I., Xu, B.-E., Akella, R., Cobb, M.H., Goldsmith, E.J.

(2002) Mol Cell 9: 1241-1249

Released	2002-07-10
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Mus musculus
Macromolecule	MAP kinase kinase 3b (protein) MITOGEN-ACTIVATED PROTEIN KINASE 14 (protein)

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1U5Q \| pdb_00001u5q	Download File View File

Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K

Zhou, T., Raman, M., Gao, Y., Earnest, S., Chen, Z., Machius, M., Cobb, M.H., Goldsmith, E.J.

(2004) Structure 12: 1891-1900

Released	2004-10-12
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Rattus norvegicus
Macromolecule	serine/threonine protein kinase TAO2 (protein)
Unique Ligands	CA

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1U5R \| pdb_00001u5r	Download File View File

Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K

Zhou, T., Raman, M., Gao, Y., Earnest, S., Chen, Z., Machius, M., Cobb, M.H., Goldsmith, E.J.

(2004) Structure 12: 1891-1900

Released	2004-10-12
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Rattus norvegicus
Macromolecule	serine/threonine protein kinase TAO2 (protein)
Unique Ligands	ATP, CA, MG

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2ERK \| pdb_00002erk	Download File View File

PHOSPHORYLATED MAP KINASE ERK2

Canagarajah, B.J., Goldsmith, E.J.

(1997) Cell 90: 859-869

Released	1998-07-01
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Rattus norvegicus
Macromolecule	EXTRACELLULAR SIGNAL-REGULATED KINASE 2 (protein)

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3DAK \| pdb_00003dak	Download File View File

Crystal Structure of Domain-Swapped OSR1 kinase domain

Lee, S., Cobb, M.H., Goldsmith, E.J.

(2008) Protein Sci 18: 304-313

Released	2009-02-10
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase OSR1 (protein)
Unique Ligands	ANP, MG

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3ENM \| pdb_00003enm	Download File View File

The structure of the MAP2K MEK6 reveals an autoinhibitory dimer

Min, X., Akella, R., He, H., Humphreys, J.M., Tsutakawa, S., Lee, S.-J., Tainer, J.A., Cobb, M.H., Goldsmith, E.J.

(2009) Structure 17: 96-104

Released	2009-03-03
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity mitogen-activated protein kinase kinase 6 (protein)
Unique Ligands	EDO, GOL, SO4

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3ERK \| pdb_00003erk	Download File View File

THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/SB220025

Wang, Z., Canagarajah, B., Boehm, J.C., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.

(1998) Structure 6: 1117-1128

Released	1999-07-22
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Rattus norvegicus
Macromolecule	EXTRACELLULAR REGULATED KINASE 2 (protein)
Unique Ligands	SB4

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4ERK \| pdb_00004erk	Download File View File

THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE

Wang, Z., Canagarajah, B., Boehm, J.C., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.

(1998) Structure 6: 1117-1128

Released	1999-07-22
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Rattus norvegicus
Macromolecule	EXTRACELLULAR REGULATED KINASE 2 (protein)
Unique Ligands	OLO, SO4

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4PWN \| pdb_00004pwn	Download File View File

Crystal structure of Active WNK1 kinase

Piala, A., Moon, T., Akella, T., He, H., Cobbm, M.H., Goldsmith, E.

(2014) Sci Signal 7: ra41-ra41

Released	2014-05-28
Method	X-RAY DIFFRACTION 1.84 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase WNK1 (protein)
Unique Ligands	PO4

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4Q2A \| pdb_00004q2a	Download File View File

WNK1: A chloride sensor via autophosphorylation

Piala, A., Moon, T., Akella, R., He, H., Cobb, M.H., Goldsmith, E.

(2014) Sci Signal 7: ra41-ra41

Released	2014-05-28
Method	X-RAY DIFFRACTION 3.5 Å
Organisms	Rattus norvegicus
Macromolecule	Serine/threonine-protein kinase WNK1 (protein)
Unique Ligands	BR

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5D9H \| pdb_00005d9h	Download File View File

Crystal structure of SPAK (STK39) dimer in the basal activity state

Taylor, C.A., Juang, Y.C., Goldsmith, E.J., Cobb, M.H.

(2015) Biochemistry 54: 5063-5071

Released	2015-09-02
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Mus musculus
Macromolecule	STE20/SPS1-related proline-alanine-rich protein kinase (protein)
Unique Ligands	ATP, MG, SO4

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5DBX \| pdb_00005dbx	Download File View File

Crystal structure of murine SPAK(T243D) in complex with AMPPNP

Juang, Y.-C.

(2015) Biochemistry 54: 5063-5071

Released	2015-09-23
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Mus musculus
Macromolecule	STE20/SPS1-related proline-alanine-rich protein kinase (protein)
Unique Ligands	ANP, MG

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5UMO \| pdb_00005umo	Download File View File

STRUCTURE OF EXTRACELLULAR SIGNAL-REGULATED KINASE

CHLEBOWICZ, J., ZHANG, F., GOLDSMITH, E.J.

(1994) Nature 367: 704-711

Released	2017-03-01
Method	X-RAY DIFFRACTION 2.26 Å
Organisms	Rattus norvegicus
Macromolecule	Mitogen-activated protein kinase 1 (protein)
Unique Ligands	SO4

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5UOJ \| pdb_00005uoj	Download File View File

THE STRUCTURE OF THE MAP KINASE P38 AT 2.1 ANGSTROMS RESOLUTION

CHLEBOWICZ, J., WANG, Z., GOLDSMITH, E.J.

(1997) Proc Natl Acad Sci U S A 94: 2327-2332

Released	2017-02-22
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Mus musculus
Macromolecule	Mitogen-activated protein kinase 14 (protein)

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6CN9 \| pdb_00006cn9	Download File View File

Crystal structure of the Kinase domain of WNK1

Akella, R., Goldsmith, E.J.

(2004) Structure 12: 1303-1311

Released	2019-03-27
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Rattus norvegicus
Macromolecule	Serine/threonine-protein kinase WNK1 (protein)
Unique Ligands	GOL, SO4