RCSB PDB: Search

2OV2 \| pdb_00002ov2	Download File View File

The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4)

Ugochukwu, E., Yang, X., Elkins, J.M., Burgess-Brown, N., Bunkoczi, G., Debreczeni, J.E.D., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Doyle, D.A., Structural Genomics Consortium (SGC)

To be published

Released	2007-03-13
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Ras-related C3 botulinum toxin substrate 3 (protein) Serine/threonine-protein kinase PAK 4 (protein)
Unique Ligands	CL, EDO, GCP, MG

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2PPI \| pdb_00002ppi	Download File View File

Structure of the BTB (Tramtrack and Bric a brac) domain of human Gigaxonin

Amos, A., Turnbull, A.P., Tickle, J., Keates, T., Bullock, A., Savitsky, P., Burgess-Brown, N., Debreczeni, J.E., Ugochukwu, E., Umeano, C., Pike, A.C.W., Papagrigoriou, E., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)

To be published

Released	2007-05-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Gigaxonin (protein)

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2PQ5 \| pdb_00002pq5	Download File View File

Crystal structure of Dual specificity protein phosphatase 13 (DUSP13)

Ugochukwu, E., Salah, E., Savitsky, P., Barr, A., Pantic, N., Niesen, F., Burgess-Brown, N., Berridge, G., Bunkoczi, G., Uppenberg, J., Pike, A.C.W., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)

To be published

Released	2007-05-22
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity protein phosphatase 13 (protein)

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2QME \| pdb_00002qme	Download File View File

Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1)

Ugochukwu, E., Yang, X., Elkins, J.M., Burgess-Brown, N., Bunkoczi, G., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Doyle, D., Structural Genomics Consortium (SGC)

To be published

Released	2007-08-28
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	CRIB domain of the Serine/threonine-protein kinase PAK 1 (protein) Ras-related C3 botulinum toxin substrate 3 (protein)
Unique Ligands	GCP, GOL, MG

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2V1X \| pdb_00002v1x	Download File View File

Crystal structure of human RECQ-like DNA helicase

Pike, A.C.W., Shrestha, B., Burgess-Brown, N., King, O., Ugochukwu, E., Watt, S., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Gileadi, O.

(2009) Proc Natl Acad Sci U S A 106: 1039

Released	2007-07-03
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	ATP-DEPENDENT DNA HELICASE Q1 (protein)
Unique Ligands	ADP, CL, EDO, MG, ZN

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2VPH \| pdb_00002vph	Download File View File

Crystal structure of the human protein tyrosine phosphatase, non- receptor type 4, PDZ domain

Roos, A.K., Wang, J., Burgess-Brown, N., Elkins, J.M., Kavanagh, K., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Bountra, C., Knapp, S.

To be published

Released	2008-03-18
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 4 (protein)

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2VSV \| pdb_00002vsv	Download File View File

Crystal structure of the PDZ domain of human rhophilin-2

Pike, A.C.W., Kochan, G., Sun, Z., Shafqat, N., Pilka, E.S., Roos, A., Elkins, J., Burgess-Brown, N., Murray, J.W., von Delft, F., Wikstrom, M., Edwards, A., Arrowsmith, C.H., Bountra, C., Oppermann, U.

To be published

Released	2008-07-15
Method	X-RAY DIFFRACTION 1.82 Å
Organisms	Homo sapiens
Macromolecule	RHOPHILIN-2 (protein)

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2VSW \| pdb_00002vsw	Download File View File

The structure of the rhodanese domain of the human dual specificity phosphatase 16

Murray, J.W., Barr, A., Pike, A.C.W., Elkins, J., Phillips, C., Wang, J., Savitsky, P., Roos, A., Bishop, S., Wickstroem, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Burgess-Brown, N., Pantic, N., Bray, J., von Delft, F., Gileadi, O., Knapp, S.

To be published

Released	2008-07-15
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	DUAL SPECIFICITY PROTEIN PHOSPHATASE 16 (protein)

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2VWR \| pdb_00002vwr	Download File View File

Crystal structure of the second pdz domain of numb-binding protein 2

Roos, A.K., Guo, K., Burgess-Brown, N., Yue, W.W., Elkins, J.M., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C.H., Wikstom, M., Edwards, A., von Delft, F., Bountra, C., Doyle, D., Oppermann, U.

To be published

Released	2008-09-16
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Homo sapiens
Macromolecule	LIGAND OF NUMB PROTEIN X 2 (protein)

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2W4O \| pdb_00002w4o	Download File View File

Crystal structure of Human CAMK4 in complex with 4-Amino(sulfamoyl- phenylamino)-triazole-carbothioic acid (2,6-difluoro-phenyl)-amide)

Muniz, J.R.C., Rellos, P., Gileadi, O., Fedorov, O., Filippakopoulos, P., Salah, E., Pike, A., Phillips, C., Niesen, F., Shrestha, L., Burgess-Brown, N., Bullock, A., Berridge, G., von Delft, F., Edwards, A.M., Bountra, C., Arrowsmith, C.H., Weigelt, J., Knapp, S.

To be published

Released	2009-01-20
Method	X-RAY DIFFRACTION 2.17 Å
Organisms	Homo sapiens
Macromolecule	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV (protein)
Unique Ligands	DKI

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2WWY \| pdb_00002wwy	Download File View File

Structure of human RECQ-like helicase in complex with a DNA substrate

Pike, A.C.W., Zhang, Y., Schnecke, C., Chaikuad, A., Krojer, T., Cooper, C.D.O., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Gileadi, O.

(2015) Proc Natl Acad Sci U S A 112: 4286

Released	2009-12-29
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	ATP-DEPENDENT DNA HELICASE Q1 (protein) 5'-D(*DA DG DC DG DT DC DG DA DG DA DT DC DCP)-3' (nucleic acid) DNA OLIGO (27BP) (nucleic acid)
Unique Ligands	EDO, SO4, ZN

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2X18 \| pdb_00002x18	Download File View File

The crystal structure of the PH domain of human AKT3 protein kinase

Vollmar, M., Wang, J., Zhang, Y., Elkins, J.M., Burgess-Brown, N., Chaikuad, A., Pike, A.C.W., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S.

To be published

Released	2010-03-16
Method	X-RAY DIFFRACTION 1.46 Å
Organisms	Homo sapiens
Macromolecule	RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE (protein)
Unique Ligands	EPE

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2X7F \| pdb_00002x7f	Download File View File

Crystal structure of the kinase domain of human Traf2- and Nck- interacting Kinase with Wee1Chk1 inhibitor

Vollmar, M., Alfano, I., Shrestha, B., Bray, J., Muniz, J.R.C., Roos, A., Filippakopoulos, P., Burgess-Brown, N., Ugochukwu, E., Gileadi, O., Phillips, C., Mahajan, P., Pike, A.C.W., Fedorov, O., Chaikuad, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S.

To be published

Released	2010-07-14
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	TRAF2 AND NCK-INTERACTING PROTEIN KINASE (protein)
Unique Ligands	824, NA

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2XVT \| pdb_00002xvt	Download File View File

Structure of the extracellular domain of human RAMP2

Quigley, A., Pike, A.C.W., Burgess-Brown, N., Krojer, T., Shrestha, L., Goubin, S., Kim, J., Das, S., Muniz, J.R.C., Canning, P., Chaikuad, A., Vollmar, M., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Barr, A.J., Carpenter, E.P.

To be published

Released	2010-12-29
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 (protein)
Unique Ligands	CA

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2XXZ \| pdb_00002xxz	Download File View File

Crystal structure of the human JMJD3 jumonji domain

Che, K.H., Yue, W.W., Krojer, T., Muniz, J.R.C., Ng, S.S., Tumber, A., Daniel, M., Burgess-Brown, N., Savitsky, P., Ugochukwu, E., Filippakopoulos, P., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.

To be published

Released	2010-11-24
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 6B (protein)
Unique Ligands	8XQ, EDO, NA, NI

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2Y7J \| pdb_00002y7j	Download File View File

Structure of human phosphorylase kinase, gamma 2

Muniz, J.R.C., Shrestha, A., Savitsky, P., Wang, J., Rellos, P., Fedorov, O., Burgess-Brown, N., Brenner, B., Berridge, G., Elkins, J.M., Krojer, T., Vollmar, M., Che, K.H., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S.

To be published

Released	2011-02-09
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (protein)
Unique Ligands	B49

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3B76 \| pdb_00003b76	Download File View File

Crystal structure of the third PDZ domain of human ligand-of-numb protein-X (LNX1) in complex with the C-terminal peptide from the coxsackievirus and adenovirus receptor

Ugochukwu, E., Burgess-Brown, N., Berridge, G., Elkins, J., Bunkoczi, G., Pike, A.C.W., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Gileadi, O., von Delft, F., Doyle, D., Structural Genomics Consortium (SGC)

To be published

Released	2007-11-13
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase LNX (protein)
Unique Ligands	EDO, NA

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3BYI \| pdb_00003byi	Download File View File

Crystal structure of human Rho GTPase activating protein 15 (ARHGAP15)

Shrestha, L., Tickle, J., Elkins, J., Burgess-Brown, N., Johansson, C., Papagrigoriou, E., Kavanagh, K., Pike, A.C.W., Ugochukwu, E., Uppenberg, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Doyle, D., Structural Genomics Consortium (SGC)

To be published

Released	2008-02-26
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	Rho GTPase activating protein 15 (protein)

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3E7V \| pdb_00003e7v	Download File View File

Crystal Structure of Human Haspin with a pyrazolo-pyrimidine ligand

Filippakopoulos, P., Eswaran, J., Keates, T., Burgess-Brown, N., Fedorov, O., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Wickstroem, M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

To be published

Released	2008-10-14
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase haspin (protein)
Unique Ligands	DZO, EDO, NI

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3F2N \| pdb_00003f2n	Download File View File

Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand

Filippakopoulos, P., Eswaran, J., Keates, T., Burgess-Brown, N., Fedorov, O., Yue, W.W., Murray, J.W., Pike, A.C.W., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

To be published

Released	2008-12-02
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase haspin (protein)
Unique Ligands	EDO, IZZ, PO4

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3FKC \| pdb_00003fkc	Download File View File

Crystal Structure of Human Zinc finger and BTB domain containing 33

Filippakopoulos, P., Bullock, A., Keates, T., Burgess-Brown, N., Muniz, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

To be published

Released	2008-12-23
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Transcriptional regulator Kaiso (protein)

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3FMD \| pdb_00003fmd	Download File View File

Crystal Structure of Human Haspin with an Isoquinoline ligand

Filippakopoulos, P., Eswaran, J., Keates, T., Burgess-Brown, N., Fedorov, O., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

To be published

Released	2008-12-30
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase haspin (protein)
Unique Ligands	EDO, IQB, NI

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3G0L \| pdb_00003g0l	Download File View File

Crystal Structure of Human Bromodomain Adjacent to Zinc finger domain 2B (BAZ2B)

Filippakopoulos, P., Keates, T., Salah, E., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

To be published

Released	2009-02-10
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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3GP0 \| pdb_00003gp0	Download File View File

Crystal Structure of Human Mitogen Activated Protein Kinase 11 (p38 beta) in complex with Nilotinib

Filippakopoulos, P., Barr, A., Fedorov, O., Keates, T., Soundararajan, M., Elkins, J., Salah, E., Burgess-Brown, N., Ugochukwu, E., Pike, A.C.W., Muniz, J., Roos, A., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

To be published

Released	2009-04-07
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Mitogen-activated protein kinase 11 (protein)
Unique Ligands	CL, EDO, NIL

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3IAR \| pdb_00003iar	Download File View File

The crystal structure of human adenosine deaminase

Ugochukwu, E., Zhang, Y., Hapka, E., Yue, W.W., Bray, J.E., Muniz, J., Burgess-Brown, N., Chaikuad, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Kavanagh, K.L., Oppermann, U., Structural Genomics Consortium (SGC)

To be published

Released	2009-08-11
Method	X-RAY DIFFRACTION 1.52 Å
Organisms	Homo sapiens
Macromolecule	Adenosine deaminase (protein)
Unique Ligands	3D1, GOL, NI, NO3

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

2OV2 | pdb_00002ov2

2PPI | pdb_00002ppi

2PQ5 | pdb_00002pq5

2QME | pdb_00002qme

2V1X | pdb_00002v1x

2VPH | pdb_00002vph

2VSV | pdb_00002vsv

2VSW | pdb_00002vsw

2VWR | pdb_00002vwr

2W4O | pdb_00002w4o

2WWY | pdb_00002wwy

2X18 | pdb_00002x18

2X7F | pdb_00002x7f

2XVT | pdb_00002xvt

2XXZ | pdb_00002xxz

2Y7J | pdb_00002y7j

3B76 | pdb_00003b76

3BYI | pdb_00003byi

3E7V | pdb_00003e7v

3F2N | pdb_00003f2n

3FKC | pdb_00003fkc

3FMD | pdb_00003fmd

3G0L | pdb_00003g0l

3GP0 | pdb_00003gp0

3IAR | pdb_00003iar