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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Akella, R."

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Search Summary

This query matches 15 Structures.

Refinements

Structure Determination Methodology

experimental (15)

Scientific Name of Source Organism

	Homo sapiens (5)
	Rattus norvegicus (5)
	Mus musculus (3)
	Paramecium bursaria Chlorella virus 1 (2)
	Trypanosoma brucei brucei (1)

Taxonomy

	Eukaryota (13)
	Varidnaviria (2)
	Eukaryota (eukaryotes) (1)

Experimental Method

X-RAY DIFFRACTION (15)

Polymer Entity Type

Protein (15)

Refinement Resolution (Å)

	1.5 - 2.0 (3)
	2.0 - 2.5 (8)
	2.5 - 3.0 (1)
	3.0 - 3.5 (2)
	3.5 - 4.0 (1)

Release Date

	2000 - 2004 (3)
	2005 - 2009 (3)
	2010 - 2014 (3)
	2015 - 2019 (1)
	2020 - 2024 (5)

Enzyme Classification Name

	Transferases (12)
	Lyases (3)

Symmetry Type

	Cyclic (5)
	Asymmetric (10)

SCOP Classification

	Alpha and beta proteins (a+b) (7)
	Artifacts (2)
	All beta proteins (1)
	Alpha and beta proteins (a/b) (1)

AllSelected

1 to 15 of 15 Structures

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1LEW \| pdb_00001lew	Download File View File

CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A

Chang, C.-I., Xu, B.-E., Akella, R., Cobb, M.H., Goldsmith, E.J.

(2002) Mol Cell 9: 1241-1249

Released	2002-07-10
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Mitogen-activated protein kinase 14 (protein) Myocyte-specific enhancer factor 2A (protein)

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1LEZ \| pdb_00001lez	Download File View File

CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS ACTIVATOR MKK3B

Chang, C.-I., Xu, B.-E., Akella, R., Cobb, M.H., Goldsmith, E.J.

(2002) Mol Cell 9: 1241-1249

Released	2002-07-10
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Mus musculus
Macromolecule	MAP kinase kinase 3b (protein) MITOGEN-ACTIVATED PROTEIN KINASE 14 (protein)

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1SZR \| pdb_00001szr	Download File View File

A Dimer interface mutant of ornithine decarboxylase reveals structure of gem diamine intermediate

Jackson, L.K., Baldwin, J., Goldsmith, E.J., Phillips, M.A.

(2004) Biochemistry 43: 12990-12999

Released	2004-10-26
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Trypanosoma brucei brucei
Macromolecule	Ornithine decarboxylase (protein)
Unique Ligands	ORX, PLG, PXP

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2NV9 \| pdb_00002nv9	Download File View File

The X-ray Crystal Structure of the Paramecium bursaria Chlorella virus arginine decarboxylase

Shah, R.H., Akella, R., Goldsmith, E., Phillips, M.A.

(2007) Biochemistry 46: 2831-2841

Released	2007-03-20
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Paramecium bursaria Chlorella virus 1
Macromolecule	A207R protein, arginine decarboxylase (protein)
Unique Ligands	PLP

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2NVA \| pdb_00002nva	Download File View File

The X-ray crystal structure of the Paramecium bursaria Chlorella virus arginine decarboxylase bound to agmatine

Shah, R.H., Akella, R., Goldsmith, E., Phillips, M.A.

(2007) Biochemistry 46: 2831-2841

Released	2007-03-20
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Paramecium bursaria Chlorella virus 1
Macromolecule	arginine decarboxylase, A207R protein (protein)
Unique Ligands	PL2

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3ENM \| pdb_00003enm	Download File View File

The structure of the MAP2K MEK6 reveals an autoinhibitory dimer

Min, X., Akella, R., He, H., Humphreys, J.M., Tsutakawa, S., Lee, S.-J., Tainer, J.A., Cobb, M.H., Goldsmith, E.J.

(2009) Structure 17: 96-104

Released	2009-03-03
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity mitogen-activated protein kinase kinase 6 (protein)
Unique Ligands	EDO, GOL, SO4

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3P4K \| pdb_00003p4k	Download File View File

The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution

Akella, R., Min, X., Wu, Q., Gardner, K.H., Goldsmith, E.J.

(2010) Structure 18: 1571-1578

Released	2011-01-05
Method	X-RAY DIFFRACTION 2.304 Å
Organisms	Mus musculus
Macromolecule	MAP kinase 14 (protein) Mitogen-activated protein kinase 14 (protein)

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4PWN \| pdb_00004pwn	Download File View File

Crystal structure of Active WNK1 kinase

Piala, A., Moon, T., Akella, T., He, H., Cobbm, M.H., Goldsmith, E.

(2014) Sci Signal 7: ra41-ra41

Released	2014-05-28
Method	X-RAY DIFFRACTION 1.84 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase WNK1 (protein)
Unique Ligands	PO4

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4Q2A \| pdb_00004q2a	Download File View File

WNK1: A chloride sensor via autophosphorylation

Piala, A., Moon, T., Akella, R., He, H., Cobb, M.H., Goldsmith, E.

(2014) Sci Signal 7: ra41-ra41

Released	2014-05-28
Method	X-RAY DIFFRACTION 3.5 Å
Organisms	Rattus norvegicus
Macromolecule	Serine/threonine-protein kinase WNK1 (protein)
Unique Ligands	BR

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5W7T \| pdb_00005w7t	Download File View File

STRUCTURE OF PHOSPHORYLATED WNK1

JIOU, J., CHLEBOWICZ, J., AKELLA, R., GOLDSMITH, E.J.

To be published

Released	2018-06-20
Method	X-RAY DIFFRACTION 2.01 Å
Organisms	Rattus norvegicus
Macromolecule	Serine/threonine-protein kinase WNK1 (protein)
Unique Ligands	ANP

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6OL2 \| pdb_00006ol2	Download File View File

Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening

Chlebowicz, J., Akella, R., Sekulski, K., Humphreys, J.M., Durbacz, M.Z., He, H., Rodan, A., Posner, B., Goldsmith, E.J.

To be published

Released	2020-04-15
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Rattus norvegicus
Macromolecule	Serine/threonine-protein kinase WNK1 (protein)
Unique Ligands	ACT, GOL, MU7

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7UOS \| pdb_00007uos	Download File View File

Structure of WNK1 inhibitor complex

Akella, R., Goldsmith, E.J., Akella, R.

To be published

Released	2023-04-19
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Rattus norvegicus
Macromolecule	Serine/threonine-protein kinase WNK1 (protein)
Unique Ligands	EDO, WIB