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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Dhe-Paganon, S."

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Search Summary

This query matches 8 Structures.

Refinements

Structure Determination Methodology

experimental (8)

Scientific Name of Source Organism

Homo sapiens (8)

Taxonomy

Eukaryota (8)

Experimental Method

X-RAY DIFFRACTION (8)

Polymer Entity Type

	Protein (8)
	DNA (3)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (2)
	2.0 - 2.5 (2)
	2.5 - 3.0 (2)
	3.0 - 3.5 (1)

Release Date

	2010 - 2014 (1)
	2015 - 2019 (2)
	2020 - 2024 (5)

Enzyme Classification Name

	Transferases (6)
	Oxidoreductases (2)

Symmetry Type

	Asymmetric (4)
	Cyclic (4)

SCOP Classification

	Alpha and beta proteins (a+b) (3)
	Artifacts (3)
	Alpha and beta proteins (a/b) (2)

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1 to 8 of 8 Structures

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4GV1 \| pdb_00004gv1	Download File View File

PKB alpha in complex with AZD5363

Addie, M., Ballard, P., Bird, G., Buttar, D., Currie, G., Davies, B., Debreczeni, J., Dry, H., Dudley, P., Greenwood, R., Hatter, G., Jestel, A., Johnson, P.D., Kettle, J.G., Lane, C., Lamont, G., Leach, A., Luke, R.W.A., Ogilvie, D., Page, K., Pass, M., Steinbacher, S., Steuber, H., Pearson, S., Ruston, L.

(2013) J Med Chem 56: 2059-2073

Released	2013-02-27
Method	X-RAY DIFFRACTION 1.49 Å
Organisms	Homo sapiens
Macromolecule	RAC-alpha serine/threonine-protein kinase (protein)
Unique Ligands	0XZ, GOL

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5L57 \| pdb_00005l57	Download File View File

Crystal structure of Iso-citrate Dehydrogenase R132H in complex with a novel inhibitor (compound 13a)

Levy, C.

(2016) J Med Chem 59: 11120-11137

Released	2016-12-14
Method	X-RAY DIFFRACTION 2.695 Å
Organisms	Homo sapiens
Macromolecule	Isocitrate dehydrogenase [NADP] cytoplasmic (protein)
Unique Ligands	6N3, NDP

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5L58 \| pdb_00005l58	Download File View File

Crystal structure of Iso-citrate Dehydrogenase 1 [IDH1 (R132H)] in complex with a novel inhibitor (Compound 2)

Levy, C.

(2016) J Med Chem 59: 11120-11137

Released	2016-12-14
Method	X-RAY DIFFRACTION 3.04 Å
Organisms	Homo sapiens
Macromolecule	Isocitrate dehydrogenase [NADP] cytoplasmic (protein)
Unique Ligands	6MX, NDP

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6I82 \| pdb_00006i82	Download File View File

Crystal structure of partially phosphorylated RET V804M tyrosine kinase domain complexed with PDD00018412

Burschowsky, D., Seewooruthun, C., Bayliss, R., Carr, M.D., Echalier, A., Jordan, A.M.

(2020) ACS Med Chem Lett 11: 497-505

Released	2020-03-11
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase receptor Ret (protein)
Unique Ligands	CL, EDO, FMT, H6W

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6I83 \| pdb_00006i83	Download File View File

Crystal structure of phosphorylated RET V804M tyrosine kinase domain complexed with PDD00018366

Burschowsky, D., Seewooruthun, C., Bayliss, R., Carr, M.D., Echalier, A., Jordan, A.M.

(2020) ACS Med Chem Lett 11: 497-505

Released	2020-03-11
Method	X-RAY DIFFRACTION 1.88 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene tyrosine-protein kinase receptor Ret (protein)
Unique Ligands	FMT, H72

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6X9I \| pdb_00006x9i	Download File View File

Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA

Pathuri, S., Horton, J.R., Cheng, X.

(2021) Nat Cancer 2: 1002-1017

Released	2021-07-07
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	DNA (cytosine-5)-methyltransferase 1 (protein) DNA (5'-D(GPAPGPGPCP(5CM)PGPCPCPTPGPC)-3') (nucleic acid) DNA (5'-D(GPCPAPGPG)-R(P(PYO))-D(PGPGPCPCPTPC)-3') (nucleic acid)
Unique Ligands	EDO, GOL, SAH, ZN

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6X9J \| pdb_00006x9j	Download File View File

Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3830052

Pathuri, S., Horton, J.R., Cheng, X.

(2021) Nat Cancer 2: 1002-1017

Released	2021-07-07
Method	X-RAY DIFFRACTION 1.79 Å
Organisms	Homo sapiens
Macromolecule	DNA (cytosine-5)-methyltransferase 1 (protein) DNA (5'-D(GPAPGPGPCP(5CM)PGPCPCPTPGPC)-3') (nucleic acid) DNA (5'-D(GPCPAPGPG)-R(P(PYO))-D(PGPGPCPCPTPC)-3') (nucleic acid)
Unique Ligands	EDO, X52, ZN

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6X9K \| pdb_00006x9k	Download File View File

Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3685032A

Pathuri, S., Horton, J.R., Cheng, X.

(2021) Nat Cancer 2: 1002-1017

Released	2021-07-07
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Homo sapiens
Macromolecule	DNA (cytosine-5)-methyltransferase 1 (protein) DNA (5'-D(GPAPGPGPCP(5CM)PGPCPCPTPGPC)-3') (nucleic acid) DNA (5'-D(GPCPAPGPG)-R(P(PYO))-D(PGPGPCPCPTPC)-3') (nucleic acid)
Unique Ligands	EDO, UXM, ZN

1 to 8 of 8 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

4GV1 | pdb_00004gv1

PKB alpha in complex with AZD5363

5L57 | pdb_00005l57

Crystal structure of Iso-citrate Dehydrogenase R132H in complex with a novel inhibitor (compound 13a)

5L58 | pdb_00005l58

Crystal structure of Iso-citrate Dehydrogenase 1 [IDH1 (R132H)] in complex with a novel inhibitor (Compound 2)

6I82 | pdb_00006i82

Crystal structure of partially phosphorylated RET V804M tyrosine kinase domain complexed with PDD00018412

6I83 | pdb_00006i83

Crystal structure of phosphorylated RET V804M tyrosine kinase domain complexed with PDD00018366

6X9I | pdb_00006x9i

Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA

6X9J | pdb_00006x9j

Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3830052

6X9K | pdb_00006x9k

Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3685032A

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

4GV1 | pdb_00004gv1

5L57 | pdb_00005l57

5L58 | pdb_00005l58

6I82 | pdb_00006i82

6I83 | pdb_00006i83

6X9I | pdb_00006x9i

6X9J | pdb_00006x9j

6X9K | pdb_00006x9k