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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Cheng, X."

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Search Summary

This query matches 363 Structures.

Refinements

Structure Determination Methodology

experimental (363)

Scientific Name of Source Organism

	Homo sapiens (201)
	synthetic construct (59)
	Mus musculus (46)
	Clostridioides difficile (24)
	Haemophilus haemolyticus (15)
	Clostridioides difficile 630 (12)
	Rattus norvegicus (12)
	Escherichia coli str. K-12 substr. MDS42 (10)
	Bos taurus (8)
	Lama glama (8)

More...

Taxonomy

	Eukaryota (274)
	Bacteria (83)
	other sequences (59)
	Duplodnaviria (10)
	Riboviria (8)
	Eukaryota (eukaryotes) (6)

Experimental Method

	X-RAY DIFFRACTION (334)
	ELECTRON MICROSCOPY (27)
	NEUTRON DIFFRACTION (1)
	SOLUTION NMR (1)

Polymer Entity Type

	Protein (363)
	DNA (174)

Refinement Resolution (Å)

	0.5 - 1.0 (2)
	1.0 - 1.5 (25)
	1.5 - 2.0 (109)
	2.0 - 2.5 (101)
	2.5 - 3.0 (87)
	3.0 - 3.5 (33)
	3.5 - 4.0 (3)
	4.0 - 4.5 (1)
	> 4.5 (1)

Release Date

	1990 - 1994 (3)
	1995 - 1999 (19)
	2000 - 2004 (25)
	2005 - 2009 (40)
	2010 - 2014 (48)
	2015 - 2019 (119)
	2020 - 2024 (109)

Enzyme Classification Name

	Transferases (142)
	Oxidoreductases (58)
	Hydrolases (55)
	Ligases (5)

Membrane Protein Annotation

	OPM (20)
	PDBTM (19)
	mpstruc (18)
	MemProtMD (13)

Symmetry Type

	Asymmetric (310)
	Cyclic (81)
	Dihedral (1)

SCOP Classification

	Alpha and beta proteins (a/b) (48)
	All beta proteins (35)
	Artifacts (16)
	Alpha and beta proteins (a+b) (12)
	All alpha proteins (12)
	Small proteins (3)

AllSelected

1 to 25 of 363 Structures

Page 1 of 15

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10MH \| pdb_000010mh	Download File View File

TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND HEMIMETHYLATED DNA CONTAINING 5,6-DIHYDRO-5-AZACYTOSINE AT THE TARGET

Sheikhnejad, G., Brank, A., Christman, J.K., Goddard, A., Alvarez, E., Ford Junior, H., Marquez, V.E., Marasco, C.J., Sufrin, J.R., O'Gara, M., Cheng, X.

(1999) J Mol Biology 285: 2021-2034

Released	1999-02-09
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Haemophilus haemolyticus
Macromolecule	PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI) (protein) DNA (5'-D(PCPCPAPTPGP(5CM)PGPCPTPGPAPC)-3') (nucleic acid) DNA (5'-D(PGPTPCPAPGP5NCPGPCPAPTPGPG)-3') (nucleic acid)
Unique Ligands	SAH

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16VP \| pdb_000016vp	Download File View File

CONSERVED CORE OF THE HERPES SIMPLEX VIRUS TRANSCRIPTIONAL REGULATORY PROTEIN VP16

Liu, Y., Gong, W., Huang, C.C., Herr, W., Cheng, X.

(1999) Genes Dev 13: 1692-1703

Released	1999-07-28
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Human alphaherpesvirus 1
Macromolecule	PROTEIN (VP16, VMW65, ATIF) (protein)
Unique Ligands	SO4

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1BM8 \| pdb_00001bm8	Download File View File

DNA-BINDING DOMAIN OF MBP1

Xu, R.-M., Koch, C., Liu, Y., Horton, J.R., Knapp, D., Nasmyth, K., Cheng, X.

(1997) Structure 5: 349-358

Released	1999-03-02
Method	X-RAY DIFFRACTION 1.71 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	TRANSCRIPTION FACTOR MBP1 (protein)

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1BOO \| pdb_00001boo	Download File View File

PVUII DNA METHYLTRANSFERASE (CYTOSINE-N4-SPECIFIC)

Gong, W., O'Gara, M., Blumenthal, R.M., Cheng, X.

(1997) Nucleic Acids Res 25: 2702-2715

Released	1998-08-12
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Proteus vulgaris
Macromolecule	PROTEIN (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE PVU II) (protein)
Unique Ligands	SAH

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1CSN \| pdb_00001csn	Download File View File

BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP

Xu, R.-M., Cheng, X.

(1995) EMBO J 14: 1015-1023

Released	1995-07-31
Method	X-RAY DIFFRACTION 2 Å
Organisms	Schizosaccharomyces pombe
Macromolecule	CASEIN KINASE-1 (protein)
Unique Ligands	ATP, MG, SO4

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1EYU \| pdb_00001eyu	Download File View File

HIGH RESOLUTION STRUCTURE OF THE PVUII ENDONCULEASE/COGNATE DNA COMPLEX AT PH 4.6

Horton, J.R., Cheng, X.

(2000) J Mol Biology 300: 1049-1056

Released	2000-07-21
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Proteus vulgaris
Macromolecule	TYPE II RESTRICTION ENZYME PVUII (protein) DNA (5'-D(TPGPAPCPCPAPGPCPTPGPGPTP*C)-3') (nucleic acid)

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1F0O \| pdb_00001f0o	Download File View File

PVUII ENDONUCLEASE/COGNATE DNA COMPLEX (GLUTARALDEHYDE-CROSSLINKED CRYSTAL) AT PH 7.5 WITH TWO CALCIUM IONS AT EACH ACTIVE SITE

Horton, J.R., Cheng, X.

(2000) J Mol Biology 300: 1049-1056

Released	2000-11-06
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Proteus vulgaris
Macromolecule	TYPE II RESTRICTION ENZYME PVUII (protein) (5'-D(TPGPAPCPCPAPGPCPTPGPGPTP*C-3') (nucleic acid)
Unique Ligands	CA

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1F3L \| pdb_00001f3l	Download File View File

CRYSTAL STRUCTURE OF THE CONSERVED CORE OF PROTEIN ARGININE METHYLTRANSFERASE PRMT3

Zhang, X., Zhou, L., Cheng, X.

(2000) EMBO J 19: 3509-3519

Released	2001-03-14
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Rattus norvegicus
Macromolecule	PROTEIN ARGININE METHYLTRANSFERASE PRMT3 (protein)
Unique Ligands	SAH

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1FJX \| pdb_00001fjx	Download File View File

STRUCTURE OF TERNARY COMPLEX OF HHAI METHYLTRANSFERASE MUTANT (T250G) IN COMPLEX WITH DNA AND ADOHCY

Vilkaitis, G., Dong, A., Weinhold, E., Cheng, X., Klimasauskas, S.

(2000) J Biological Chem 275: 38722-38730

Released	2000-12-15
Method	X-RAY DIFFRACTION 2.26 Å
Organisms	Haemophilus haemolyticus
Macromolecule	HHAI DNA METHYLTRANSFERASE (protein) DNA (5'-D(TPGPAPTPAPGPCPGPCPTPAPTP*C)-3') (nucleic acid)
Unique Ligands	SAH, SO4

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1G55 \| pdb_00001g55	Download File View File

Structure of human DNMT2, an enigmatic DNA methyltransferase homologue

Dong, A., Yoder, J.A., Zhang, X., Zhou, L., Bestor, T.H., Cheng, X.

(2001) Nucleic Acids Res 29: 439-448

Released	2001-01-17
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	DNA CYTOSINE METHYLTRANSFERASE DNMT2 (protein)
Unique Ligands	BME, GOL, SAH, SO4

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1HMY \| pdb_00001hmy	Download File View File

CRYSTAL STRUCTURE OF THE HHAI DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE

Cheng, X.

(1993) Cell 74: 299-307

Released	1993-10-31
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Haemophilus haemolyticus
Macromolecule	HaeIII METHYLTRANSFERASE (protein)
Unique Ligands	SAM

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1JQD \| pdb_00001jqd	Download File View File

Crystal Structure Analysis of Human Histamine Methyltransferase (Thr105 Polymorphic Variant) Complexed with AdoHcy and Histamine

Horton, J.R., Sawada, K., Nishibori, M., Zhang, X., Cheng, X.

(2001) Structure 9: 837-849

Released	2002-08-06
Method	X-RAY DIFFRACTION 2.28 Å
Organisms	Homo sapiens
Macromolecule	Histamine N-Methyltransferase (protein)
Unique Ligands	HSM, SAH

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1JQE \| pdb_00001jqe	Download File View File

Crystal Structure Analysis of Human Histamine Methyltransferase (Ile105 Polymorphic Variant) Complexed with AdoHcy and Antimalarial Drug Quinacrine

Horton, J.R., Sawada, K., Nishibori, M., Zhang, X., Cheng, X.

(2001) Structure 9: 837-849

Released	2002-08-06
Method	X-RAY DIFFRACTION 1.91 Å
Organisms	Homo sapiens
Macromolecule	Histamine N-Methyltransferase (protein)
Unique Ligands	QUN, SAH, UNX

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1KHC \| pdb_00001khc	Download File View File

Crystal Structure of the PWWP Domain of Mammalian DNA Methyltransferase Dnmt3b

Qiu, C., Sawada, K., Zhang, X., Cheng, X.

(2002) Nat Struct Biol 9: 217-224

Released	2002-02-27
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Mus musculus
Macromolecule	DNA cytosine-5 methyltransferase 3B2 (protein)
Unique Ligands	UNX

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1LBA \| pdb_00001lba	Download File View File

THE STRUCTURE OF BACTERIOPHAGE T7 LYSOZYME, A ZINC AMIDASE AND AN INHIBITOR OF T7 RNA POLYMERASE

Cheng, X.

(1994) Proc Natl Acad Sci U S A 91: 4034-4038

Released	1994-04-30
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Escherichia phage T7
Macromolecule	T7 LYSOZYME (protein)
Unique Ligands	ZN

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1M0E \| pdb_00001m0e	Download File View File

ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASE

Zhou, L., Cheng, X., Connolly, B.A., Dickman, M.J., Hurd, P.J., Hornby, D.P.

(2002) J Mol Biology 321: 591-599

Released	2002-09-18
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Haemophilus haemolyticus
Macromolecule	Modification methylase HhaI (protein) 5'-D(PCPCPAPTPGPCPGPCPTPGPAPC)-3' (nucleic acid) 5'-D(PGPTPCPAPGP(Z)PGPCPAPTPGPG)-3' (nucleic acid)
Unique Ligands	SAH

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1MHT \| pdb_00001mht	Download File View File

COVALENT TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE, DNA AND S-ADENOSYL-L-HOMOCYSTEINE

Cheng, X.

(1994) Cell 76: 357-369

Released	1995-06-03
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Haemophilus haemolyticus
Macromolecule	PROTEIN (HHAI METHYLTRANSFERASE) (protein) DNA (5'-D(TPGPAPTPAPGP(C36)PGPCPTPAPTPC)-3') (nucleic acid) DNA (5'-D(PGPAPTPAPGP(C36)PGPCPTPAPTP*C)-3') (nucleic acid)
Unique Ligands	SAH

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1ML9 \| pdb_00001ml9	Download File View File

Structure of the Neurospora SET domain protein DIM-5, a histone lysine methyltransferase

Zhang, X., Tamaru, H., Khan, S.I., Horton, J.R., Keefe, L.J., Selker, E.U., Cheng, X.

(2002) Cell 111: 117-127

Released	2002-10-23
Method	X-RAY DIFFRACTION 1.98 Å
Organisms	Neurospora crassa
Macromolecule	Histone H3 methyltransferase DIM-5 (protein)
Unique Ligands	UNL, ZN

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1MOZ \| pdb_00001moz	Download File View File

ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae

Amor, J.C., Horton, J.R., Zhu, X., Wang, Y., Sullards, C., Ringe, D., Cheng, X., Kahn, R.A.

(2001) J Biological Chem 276: 42477-42484

Released	2002-10-09
Method	X-RAY DIFFRACTION 3.17 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	ADP-ribosylation factor-like protein 1 (protein)
Unique Ligands	GDP

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1MR3 \| pdb_00001mr3	Download File View File

Saccharomyces cerevisiae ADP-ribosylation Factor 2 (ScArf2) complexed with GDP-3'P at 1.6A resolution

Amor, J.-C., Horton, J.R., Zhu, X., Wang, Y., Sullards, C., Ringe, D., Cheng, X., Kahn, R.A.

(2001) J Biological Chem 276: 42477-42484

Released	2002-11-20
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	ADP-ribosylation factor 2 (protein)
Unique Ligands	EDO, EOH, G3D, GOL, MG, PDO

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1NGN \| pdb_00001ngn	Download File View File

Mismatch repair in methylated DNA. Structure of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4

Wu, P., Qiu, C., Sohail, A., Zhang, X., Bhagwat, A.S., Cheng, X.

(2003) J Biological Chem 278: 5285-5291

Released	2003-03-18
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Mus musculus
Macromolecule	methyl-CpG binding protein MBD4 (protein)

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1OR8 \| pdb_00001or8	Download File View File

Structure of the Predominant protein arginine methyltransferase PRMT1

Zhang, X., Cheng, X.

(2003) Structure 11: 509-520

Released	2003-08-26
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Rattus norvegicus
Macromolecule	Protein arginine N-methyltransferase 1 (protein) Substrate peptide (protein)
Unique Ligands	GOL, SAH, UNL

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1ORH \| pdb_00001orh	Download File View File

Structure of the Predominant Protein Arginine Methyltransferase PRMT1

Zhang, X., Cheng, X.

(2003) Structure 11: 509-520

Released	2003-08-26
Method	X-RAY DIFFRACTION 2.64 Å
Organisms	Rattus norvegicus
Macromolecule	Protein arginine N-methyltransferase 1 (protein) Substrate peptide (protein)
Unique Ligands	GOL, SAH

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1ORI \| pdb_00001ori	Download File View File

Structure of the predominant protein arginine methyltransferase PRMT1

Zhang, X., Cheng, X.

(2003) Structure 11: 509-520

Released	2003-05-27
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Rattus norvegicus
Macromolecule	Protein arginine N-methyltransferase 1 (protein)
Unique Ligands	SAH, UNL

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1PEG \| pdb_00001peg	Download File View File

Structural basis for the product specificity of histone lysine methyltransferases

Zhang, X., Yang, Z., Khan, S.I., Horton, J.R., Tamaru, H., Selker, E.U., Cheng, X.

(2003) Mol Cell 12: 177-185

Released	2003-08-05
Method	X-RAY DIFFRACTION 2.59 Å
Organisms	Homo sapiens Neurospora crassa
Macromolecule	Histone H3 (protein) histone H3 methyltransferase DIM-5 (protein)
Unique Ligands	SAH, ZN

1 to 25 of 363 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

10MH | pdb_000010mh

16VP | pdb_000016vp

1BM8 | pdb_00001bm8

1BOO | pdb_00001boo

1CSN | pdb_00001csn

1EYU | pdb_00001eyu

1F0O | pdb_00001f0o

1F3L | pdb_00001f3l

1FJX | pdb_00001fjx

1G55 | pdb_00001g55

1HMY | pdb_00001hmy

1JQD | pdb_00001jqd

1JQE | pdb_00001jqe

1KHC | pdb_00001khc

1LBA | pdb_00001lba

1M0E | pdb_00001m0e

1MHT | pdb_00001mht

1ML9 | pdb_00001ml9

1MOZ | pdb_00001moz

1MR3 | pdb_00001mr3

1NGN | pdb_00001ngn

1OR8 | pdb_00001or8

1ORH | pdb_00001orh

1ORI | pdb_00001ori

1PEG | pdb_00001peg